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Lymphocyte-activation gene 3

Lymphocyte-activation gene 3, also known as LAG-3, is a protein which in humans is encoded by the LAG3 gene. LAG3, which was discovered in 1990 and was designated CD223 (cluster of differentiation 223) after the Seventh Human Leucocyte Differentiation Antigen Workshop in 2000, is a cell surface molecule with diverse biological effects on T cell function…

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History

29 related topics

Function

9 related topics

Use as a pharmaceutical and as a drug target

7 related topics

Gene

4 related topics

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Aliases
LAG3, CD223, lymphocyte activating 3
Band
12p13.31 · 6|6 F2
Bgee
granulocyte · right ovary · left ovary · gonad · spleen
BioGPS
More reference expression data
Chr.
Chromosome 12 (human) · Chromosome 6 (mouse)
Databases
NCBI: entry; OMA: entry

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Overview

Gene

Protein

Tissue distribution

Function

Use as a pharmaceutical and as a drug target

History

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Map overview Semantic statistics

Lymphocyte-activation gene 3

Nodes73
Edges72
Triples67
Avg. degree1.97
Density0.027397
Components1

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Lymphocyte-activation gene 3

Top relations

Bgee · 18
Lymphocyte-activation gene 3 → body of uterus, embryo, epiblast, gonad, granulocyte, left ovary, left uterine tube, lip, lymph node, primary visual cortex, right lobe of liver, right ovary, spleen, superior frontal gyrus, testicle, thymus, ventricular zone, zygote
RNA expression pattern · 18
Lymphocyte-activation gene 3 → body of uterus, embryo, epiblast, gonad, granulocyte, left ovary, left uterine tube, lip, lymph node, primary visual cortex, right lobe of liver, right ovary, spleen, superior frontal gyrus, testicle, thymus, ventricular zone, zygote
Gene ontology · 11
Lymphocyte-activation gene 3 → antigen binding, antigen processing and presentation of exogenous peptide antigen via MHC class II, cell surface receptor signaling pathway, external side of plasma membrane, integral component of membrane, membrane, MHC class II protein binding, negative regulation of T cell activation, plasma membrane, positive regulation of natural killer cell mediated cytotoxicity, transmembrane signaling receptor activity
Band · 2
Lymphocyte-activation gene 3 → 12p13.31, 6|6 F2
Chr. · 2
Lymphocyte-activation gene 3 → Chromosome 12 (human), Chromosome 6 (mouse)
End · 2
Lymphocyte-activation gene 3 → 124,888,668 bp, 6,778,455 bp
Aliases · 1
Lymphocyte-activation gene 3 → LAG3, CD223, lymphocyte activating 3
BioGPS · 1
Lymphocyte-activation gene 3 → More reference expression data
Databases · 1
Lymphocyte-activation gene 3 → NCBI: entry; OMA: entry
Ensembl · 1
Lymphocyte-activation gene 3 → ENSG00000089692

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Important terminology

lag3 lag-3 cells human also cd4 cell protein shown gene cd8 function immune mhc class ii found reported antibodies demonstrated

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Lymphocyte-activation gene 3AliasesLAG3, CD223, lymphocyte activating 31.00infobox
Lymphocyte-activation gene 3Band12p13.311.00infobox
Lymphocyte-activation gene 3Band6|6 F21.00infobox
Lymphocyte-activation gene 3Bgeegranulocyte1.00infobox
Lymphocyte-activation gene 3Bgeeright ovary1.00infobox
Lymphocyte-activation gene 3Bgeeleft ovary1.00infobox
Lymphocyte-activation gene 3Bgeegonad1.00infobox
Lymphocyte-activation gene 3Bgeespleen1.00infobox
Lymphocyte-activation gene 3Bgeetesticle1.00infobox
Lymphocyte-activation gene 3Bgeeright lobe of liver1.00infobox
Lymphocyte-activation gene 3Bgeebody of uterus1.00infobox
Lymphocyte-activation gene 3Bgeeleft uterine tube1.00infobox
Lymphocyte-activation gene 3Bgeelymph node1.00infobox
Lymphocyte-activation gene 3Bgeeembryo1.00infobox
Lymphocyte-activation gene 3Bgeethymus1.00infobox
Lymphocyte-activation gene 3Bgeezygote1.00infobox
Lymphocyte-activation gene 3Bgeelip1.00infobox
Lymphocyte-activation gene 3Bgeesuperior frontal gyrus1.00infobox
Lymphocyte-activation gene 3Bgeeepiblast1.00infobox
Lymphocyte-activation gene 3Bgeeprimary visual cortex1.00infobox
Lymphocyte-activation gene 3Bgeeventricular zone1.00infobox
Lymphocyte-activation gene 3BioGPSMore reference expression data1.00infobox
Lymphocyte-activation gene 3Chr.Chromosome 12 (human)1.00infobox
Lymphocyte-activation gene 3Chr.Chromosome 6 (mouse)1.00infobox
Lymphocyte-activation gene 3DatabasesNCBI: entry; OMA: entry1.00infobox
Lymphocyte-activation gene 3End6,778,455 bp1.00infobox
Lymphocyte-activation gene 3End124,888,668 bp1.00infobox
Lymphocyte-activation gene 3EnsemblENSG000000896921.00infobox
Lymphocyte-activation gene 3Entrez39021.00infobox
Lymphocyte-activation gene 3External IDsOMIM: 153337; MGI: 106588; GeneCards: LAG31.00infobox

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