MDA5

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Structure

RNA helicase N-terminus C-terminal domain DEAD box Ribosome

6 related topics

Clinical significance

Singleton-Merten Syndrome Aicardi–Goutières syndrome SNPs Type 1 diabetes Amyopathic dermatomyositis

6 related topics

Function

DsRNA viruses Positive Negative Chemical modifications of RNA 5′ cap

5 related topics

Overview

RIG-I-like receptor DsRNA Helicase Enzyme Gene

13 related topics

Key facts & relationships

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3.6.4.13: ↗
Aliases: IFIH1, AGS7, Hlcd, IDDM19, MDA-5, MDA5, RLR-2, SGMRT1, interferon induced with helicase C domain 1, IMD95
Available structures: Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2RQB, 3B6E, 3GA3, 4GL2
Band: 2q24.2 · 2|2 C1.3
Bgee: palpebral conjunctiva · parotid gland · jejunal mucosa · monocyte · epithelium of nasopharynx
BioGPS: More reference expression data

Topics to explore

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Overview

RIG-I-like receptor
DsRNA
Helicase
Enzyme
Gene
RIG-I
LGP2
Pattern recognition receptor
Viruses Virus
CARD domains CARD domain
Mitochondrial antiviral signaling proteins Mitochondrial antiviral signaling protein
Caspase activation and recruitment domains Caspase activation and recruitment domain
Type I interferon Interferon type I

Function

DsRNA viruses Double-stranded RNA viruses
Positive Positive-sense single-stranded RNA virus
Negative Negative-sense single-stranded RNA virus
Chemical modifications of RNA RNA modification
5′ cap Five-prime cap

Structure

Clinical significance

Singleton-Merten Syndrome Singleton Merten Syndrome
Aicardi–Goutières syndrome
SNPs Single-nucleotide polymorphism
Type 1 diabetes
Amyopathic dermatomyositis Dermatomyositis
Interstitial lung disease

Advanced semantic analysis

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Map overview Semantic statistics

Nodes35

Edges34

Triples133

Avg. degree1.94

Density0.057143

Components1

How this topic connects Entity context

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MDA5

Top relations

Gene ontology · 32

MDA5 → ATP binding, cellular response to exogenous dsRNA, cytoplasm, cytoplasmic pattern recognition receptor signaling pathway in response to virus, cytosol, defense response to virus, detection of virus, DNA binding, double-stranded RNA binding, helicase activity, hydrolase activity, identical protein binding, immune system process, innate immune response, MDA-5 signaling pathway, metal ion binding, negative regulation of type I interferon production, nucleotide binding, nucleus, positive regulation of interferon-alpha production

Bgee · 20

MDA5 → appendix, conjunctival fornix, epithelium of nasopharynx, epithelium of small intestine, germinal epithelium, intestinal epithelium, intestinal villus, jejunal mucosa, jejunum, left colon, left lobe of liver, monocyte, mucous cell of stomach, palpebral conjunctiva, Paneth cell, parietal pleura, parotid gland, sperm, vestibular membrane of cochlear duct, visceral pleura

RNA expression pattern · 20

related to Structure · 20

MDA5 → Another, Apart, Asp-Glu-Ala-Asp, ATP-dependent DExD/H, Based, C-activating, C-terminal, CARD, CTD, DEAD, Hel2, IFN-β, Irreversible, It, MEZ, N-terminus, RecA-like Hel1, RNA, They, This

related to Clinical significance · 6

MDA5 → Aicardi, Goutières, IFIH1/MDA5, Mutations, Singleton-Merten Syndrome, Some IFIH1 SNPs

related to As a pattern recognition receptor · 4

MDA5 → O-methylation, RNA, The, These

Band · 2

MDA5 → 2q24.2, 2|2 C1.3

Chr. · 2

MDA5 → Chromosome 2 (human), Chromosome 2 (mouse)

End · 2

MDA5 → 162,318,684 bp, 62,476,599 bp

3.6.4.13 · 1

MDA5 → ↗

Important terminology Word statistics

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Important terminology

rna bp helicase also gene ifih1 chr human band receptor dsrna recognition chromosome viruses protein cellular response pattern interferon lgp2

Entity relationships Subject–Predicate–Object triples

Subject	Predicate	Object	Confidence	Src
MDA5	3.6.4.13	↗	1.00	infobox
MDA5	Aliases	IFIH1, AGS7, Hlcd, IDDM19, MDA-5, MDA5, RLR-2, SGMRT1, interferon induced with helicase C domain 1, IMD95	1.00	infobox
MDA5	Available structures	Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2RQB, 3B6E, 3GA3, 4GL2	1.00	infobox
MDA5	Band	2q24.2	1.00	infobox
MDA5	Band	2\|2 C1.3	1.00	infobox
MDA5	Bgee	palpebral conjunctiva	1.00	infobox
MDA5	Bgee	parotid gland	1.00	infobox
MDA5	Bgee	jejunal mucosa	1.00	infobox
MDA5	Bgee	monocyte	1.00	infobox
MDA5	Bgee	epithelium of nasopharynx	1.00	infobox
MDA5	Bgee	sperm	1.00	infobox
MDA5	Bgee	parietal pleura	1.00	infobox
MDA5	Bgee	visceral pleura	1.00	infobox
MDA5	Bgee	appendix	1.00	infobox
MDA5	Bgee	germinal epithelium	1.00	infobox
MDA5	Bgee	mucous cell of stomach	1.00	infobox
MDA5	Bgee	conjunctival fornix	1.00	infobox
MDA5	Bgee	jejunum	1.00	infobox
MDA5	Bgee	intestinal epithelium	1.00	infobox
MDA5	Bgee	left colon	1.00	infobox
MDA5	Bgee	left lobe of liver	1.00	infobox
MDA5	Bgee	Paneth cell	1.00	infobox
MDA5	Bgee	intestinal villus	1.00	infobox
MDA5	Bgee	vestibular membrane of cochlear duct	1.00	infobox
MDA5	Bgee	epithelium of small intestine	1.00	infobox
MDA5	BioGPS	More reference expression data	1.00	infobox
MDA5	Chr.	Chromosome 2 (human)	1.00	infobox
MDA5	Chr.	Chromosome 2 (mouse)	1.00	infobox
MDA5	Databases	NCBI: entry; OMA: entry	1.00	infobox
MDA5	End	162,318,684 bp	1.00	infobox

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