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DEAD box

DEAD box proteins are involved in an assortment of metabolic processes that typically involve RNAs, but in some cases also other nucleic acids. They are highly conserved in nine motifs and can be found in most prokaryotes and eukaryotes, but not all. Many organisms, including humans, contain DEAD-box (SF2) helicases, which are involved in RNA metabolism.

Biological functions, DEAD box family & Related families

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Biological functions

TranscriptionPre-mRNA splicingRibosomeBiogenesisTransesterifications
10 related topics

DEAD box family

NTP binding sitesWalker B motif
2 related topics

Related families

SKI2
1 related topics

Overview

RNAsNucleic acidsMotifsProkaryotesEukaryotes
7 related topics

Key facts & relationships

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AlphaFold
IPR011545 · PF00270
Available protein structures:
IPR011545 · PF00270
CDD
cd00268
InterPro
IPR011545
PDB
IPR011545 PF00270 (ECOD; PDBsum)
Pfam
PF00270

Topics to explore

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Overview

DEAD box family

Related families

Biological functions

Advanced semantic analysis

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Map overview Semantic statistics

DEAD box

Nodes25
Edges24
Triples80
Avg. degree1.92
Density0.08
Components1

How this topic connects Entity context

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DEAD box

Top relations

related to Pre-mRNA splicing · 21
DEAD box → As, Brr213, DEAD, DEAH, DExD/H, Pre-mRNA, Prp16, Prp2, Prp22, Prp28, Prp43, Prp5, RNA, RNP, Sub2, There, U1, U2, U4, U5
related to DEAD box family · 20
DEAD box → ATP, C-terminal, D-E-A-D, DEAD, II, III, IV, Motif, Motif II, MSS116, N-terminal, NTP, PL10, Q-motif, RNA, SrmB, The, There, VI, Walker
related to Related families · 10
DEAD box → ATP, DEAD, DEAH, DExD/H, It, NTPase, RNA, SKI2, The DEAH, These
related to Translation initiation · 7
DEAD box → DEAD, Ded1, It, RNA-dependent ATPase, The, This, Vasa
AlphaFold · 2
DEAD box → IPR011545, PF00270
Available protein structures: · 2
DEAD box → IPR011545, PF00270
related to Biological functions · 2
DEAD box → DEAD, RNA
CDD · 1
DEAD box → cd00268
InterPro · 1
DEAD box → IPR011545
PDB · 1
DEAD box → IPR011545 PF00270 (ECOD; PDBsum)

Important terminology Word statistics

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Important terminology

dead box proteins rna family also initiation deah found involved splicing translation protein metabolism conserved motifs helicases motif required nine

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
DEAD boxAlphaFoldIPR0115451.00infobox
DEAD boxAlphaFoldPF002701.00infobox
DEAD boxAvailable protein structures:IPR0115451.00infobox
DEAD boxAvailable protein structures:PF002701.00infobox
DEAD boxCDDcd002681.00infobox
DEAD boxInterProIPR0115451.00infobox
DEAD boxPDBIPR011545 PF00270 (ECOD; PDBsum)1.00infobox
DEAD boxPfamPF002701.00infobox
DEAD boxPfam clanCL00231.00infobox
DEAD boxPROSITEPDOC000391.00infobox
DEAD boxSCOP21qva / SCOPe / SUPFAM1.00infobox
DEAD boxSymbolDEAD1.00infobox

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    Min side: 3
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