Hydroxyprogesterone caproate

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Explore the main themes, entities and connections around Hydroxyprogesterone caproate. Start with the topic map, then use the sections below for research and deeper semantic analysis.

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Medical uses

Randomized controlled trial Cervical cerclage Necrotizing enterocolitis Intraventricular hemorrhage National Institutes of Health

26 related topics

Chemistry

Pregnane Steroid Derivative Hexanoate Analogues

13 related topics

Side effects

Soreness Itching Bruising Urticaria Pruritus

12 related topics

History

Schering AG Medical literature Japan Squibb KV Pharmaceutical

6 related topics

Key facts & relationships

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3D model (JSmol): Interactive image
ATC code: G03DA03 (WHO) G03FA02 (WHO)
Bioavailability: Oral: Very low (~3% in rats) Intramuscular: 100% (in rats)
CAS Number: 630-56-8 Y
ChEBI: CHEBI:5812
ChEMBL: ChEMBL1200848

Topics to explore

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Overview

Medication
Food and Drug Administration
Pharmacovigilance Risk Assessment Committee
European Medicines Agency
Progestins Progestin
Preterm delivery Preterm birth
Pregnancy
Gynecological disorders Gynecological disorder
Estrogenic Estrogen (medication)
Gravibinon
Primosiston
Injectable birth control Combined injectable birth control
Chinese Injectable No. 1
Oral Oral administration
Intramuscular injection
Subcutaneous Subcutaneous injection
Well tolerated Tolerability
Side effects Side effect
Injection site reactions Injection site reaction
Pain
Swelling Swelling (medical)
Gestational diabetes
Synthetic Synthetic compound
Progestogenic Progestogen (medication)
Agonist
Progesterone receptor
Biological target
Progesterone
Antimineralocorticoid
Hormonal Hormonal agent

Contraindications

Side effects

Overdose

Overdose
Symptoms Symptom

Interactions

Drug interaction

Chemistry

History

Society and culture

Generic name Generic term
INN International Nonproprietary Name
USAN United States Adopted Name
BANM British Approved Name
JAN Japanese Accepted Name
Compounding pharmacies Compounding pharmacy

Research

Veterinary uses

Ungulates Ungulate

Advanced semantic analysis

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Map overview Semantic statistics

Nodes254

Edges253

Triples167

Avg. degree1.99

Density0.007874

Components1

How this topic connects Entity context

See the strongest relationship patterns around the current topic before diving into the raw triples.

Hydroxyprogesterone caproate

Top relations

related to history · 22

Hydroxyprogesterone caproate → After, Along, Delalutin, Due, FDA, FDA Accelerated Approval Programs, February, It, Japan, Karl Junkmann, KV Pharmaceutical, Makena, NIH-sponsored, PROLONG, Renewed, Schering AG, Squibb, The, The FDA, Under

related to Preterm birth · 22

Hydroxyprogesterone caproate → Based, Drug Administration, FDA, Furthermore, Guidelines, Health, Hydroxyprogesterone, III, IM, In, Level, Maternal Fetal Medicine Clinic, May, National Institutes, NIH, Of, One, Society, The, There

related to Availability · 15

Hydroxyprogesterone caproate → Asia, Australia, Canada, Central, China, Europe, Hydroxyprogesterone, It, Japan, Mexico, New Zealand, South Africa, South America, United Kingdom, United States

related to Available forms · 12

Hydroxyprogesterone caproate → Chinese Injectable No, EP Hormone Depot, Gravibinon, Hydroxyprogesterone, In, It, Japan, Makena, OHPC, Primosiston, Proluton, The

related to Economics · 9

Hydroxyprogesterone caproate → FDA, Hydroxyprogesterone, KV Pharmaceutical, Makena, The FDA, This, United States, US, With

related to Names · 8

Hydroxyprogesterone caproate → BANMTooltip British Approved Name, Hydroxyprogesterone, INNTooltip International Nonproprietary Name, It, JANTooltip Japanese Accepted Name, Name, OHPC, USANTooltip United States Adopted

has effect · 5

Hydroxyprogesterone caproate → Hydroxyprogesterone, In, Injection, Numerically, Side

related to Chemistry · 4

Hydroxyprogesterone caproate → Analogues, C17α, Hydroxyprogesterone, It

related to Other uses · 4

Hydroxyprogesterone caproate → However, Hydroxyprogesterone, It, The

is a · 3

Hydroxyprogesterone caproate → much more potent progestogen than 17α-hydroxyprogesterone, progestin, progestin medication which was used to prevent preterm birth in pregnant women with a history of the condition and to treat gynecological disorders

Important terminology Word statistics

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

caproate hydroxyprogesterone progesterone intramuscular women injection mg found used birth medication 17α-hydroxyprogesterone study also brand pregnant effects preterm activity name

Entity relationships Subject–Predicate–Object triples

Subject	Predicate	Object	Confidence	Src
Hydroxyprogesterone caproate	3D model (JSmol)	Interactive image	1.00	infobox
Hydroxyprogesterone caproate	ATC code	G03DA03 (WHO) G03FA02 (WHO)	1.00	infobox
Hydroxyprogesterone caproate	Bioavailability	Oral: Very low (~3% in rats) Intramuscular: 100% (in rats)	1.00	infobox
Hydroxyprogesterone caproate	CAS Number	630-56-8 Y	1.00	infobox
Hydroxyprogesterone caproate	ChEBI	CHEBI:5812	1.00	infobox
Hydroxyprogesterone caproate	ChEMBL	ChEMBL1200848	1.00	infobox
Hydroxyprogesterone caproate	ChemSpider	148552 Y	1.00	infobox
Hydroxyprogesterone caproate	CompTox Dashboard (EPA)	DTXSID6043915	1.00	infobox
Hydroxyprogesterone caproate	Drug class	Progestogen; Progestin; Progestogen ester; Antigonadotropin	1.00	infobox
Hydroxyprogesterone caproate	DrugBank	DB06789 Y	1.00	infobox
Hydroxyprogesterone caproate	ECHA InfoCard	100.010.127	1.00	infobox
Hydroxyprogesterone caproate	Elimination half-life	Non-pregnant: 7.8 days Singlet: 16–17 days Twins: 10 days	1.00	infobox
Hydroxyprogesterone caproate	Excretion	Feces: 50% Urine: 30%	1.00	infobox
Hydroxyprogesterone caproate	Formula	C27H40O4	1.00	infobox
Hydroxyprogesterone caproate	KEGG	D00949	1.00	infobox
Hydroxyprogesterone caproate	Legal status	US: withdrawn	1.00	infobox
Hydroxyprogesterone caproate	Metabolism	Reduction and hydroxylation (via CYP3A4, CYP3A5, CYP3A7) and conjugation (glucuronidation, sulfation, acetylation)	1.00	infobox
Hydroxyprogesterone caproate	Molar mass	428.613 g·mol−1	1.00	infobox
Hydroxyprogesterone caproate	Other names	OHPC; Hydroxyprogesterone capronate; Hydroxyprogesterone hexanoate; 17α-Hydroxyprogesterone caproate; 17α-OHPC; 17-Hydroxyprogesterone caproate; 17-OHPC; 17-HPC; 17α-HPC; HPC; L…	1.00	infobox
Hydroxyprogesterone caproate	Protein binding	Extensive (to albumin, not to CBGTooltip corticosteroid-binding globulin or (likely) SHBGTooltip sex hormone-binding globulin)	1.00	infobox
Hydroxyprogesterone caproate	PubChem CID	169870	1.00	infobox
Hydroxyprogesterone caproate	Routes of administration	Intramuscular injection, subcutaneous autoinjection	1.00	infobox
Hydroxyprogesterone caproate	Trade names	Delalutin, Proluton, Makena, others	1.00	infobox
Hydroxyprogesterone caproate	UNII	276F2O42F5	1.00	infobox
Hydroxyprogesterone caproate	is a	progestin medication which was used to prevent preterm birth in pregnant women with a history of the condition and to treat gynecological disorders	0.90	text
Hydroxyprogesterone caproate	is a	progestin	0.90	text
Hydroxyprogesterone caproate	is a	much more potent progestogen than 17α-hydroxyprogesterone	0.90	text

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