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HERC2: History, Products & Standards

HERC2, or HECT and RLD domain containing E3 ubiquitin protein ligase 2, is a giant E3 ubiquitin protein ligase, implicated in DNA repair regulation, pigmentation and neurological disorders. It is encoded by a gene of the same name belonging to the HERC family, which typically encodes large protein products with C-terminal HECT domains and one or more…

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HERC2 topic overview

The analysis highlights History, Products and Standards as prominent areas in the source structure around HERC2.

Related topics
47
Source areas
6
Connected nodes
53
Extracted relationships
153
Concept neighborhoods
16
Bridge connections
53

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Protein function · 22 topics
Clinical significance · 6 topics
Gene locus · 6 topics
Interactions · 6 topics
Overview · 5 topics
History · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

2.3.2.26
Aliases
HERC2, p528, D15F37S1, MRT38, SHEP1, jdf2, HECT and RLD domain containing E3 ubiquitin protein ligase 2, LOC107987422
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2KEO, 3KCI, 4L1M
Band
15q13.1 · 7 B5|7 33.42 cM
Bgee
sural nerve · right hemisphere of cerebellum · pituitary gland · corpus callosum · muscle layer of sigmoid colon
BioGPS
More reference expression data

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

History

Gene locus

Protein function

Clinical significance

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How HERC2 connects Entity context

The extracted context around HERC2 shows recurring relationship patterns in the source. For example, HERC2 → cellular response to DNA damage stimulus, centriole, cytoplasm, cytoskeleton, DNA repair, double-strand break repair via nonhomologous end joining, guanyl-nucleotide exchange factor activity, intracellular protein transport, membrane, metal ion binding, mitochondrial inner membrane, nucleoplasm, nucleus, proteasome-mediated ubiquitin-dependent protein catabolic process, protein binding, protein ubiquitination, regulation of molecular function, spermatogenesis, SUMO binding, transferase activity Another extracted example is HERC2 → anterior pituitary, cerebellar cortex, corpus callosum, dentate gyrus of hippocampal formation granule cell, medial dorsal nucleus, medial vestibular nucleus, muscle layer of sigmoid colon, muscle of thigh, neural layer of retina, pituitary gland, prefrontal cortex, primary visual cortex, right frontal lobe, right hemisphere of cerebellum, secondary oocyte, superior frontal gyrus, sural nerve, ventral tegmental area, zygote. Use these groups to spot repeated connection types before inspecting the individual relationships.

HERC2

Top relations

Gene ontology · 24
HERC2 → cellular response to DNA damage stimulus, centriole, cytoplasm, cytoskeleton, DNA repair, double-strand break repair via nonhomologous end joining, guanyl-nucleotide exchange factor activity, intracellular protein transport, membrane, metal ion binding, mitochondrial inner membrane, nucleoplasm, nucleus, proteasome-mediated ubiquitin-dependent protein catabolic process, protein binding, protein ubiquitination, regulation of molecular function, spermatogenesis, SUMO binding, transferase activity
Bgee · 19
HERC2 → anterior pituitary, cerebellar cortex, corpus callosum, dentate gyrus of hippocampal formation granule cell, medial dorsal nucleus, medial vestibular nucleus, muscle layer of sigmoid colon, muscle of thigh, neural layer of retina, pituitary gland, prefrontal cortex, primary visual cortex, right frontal lobe, right hemisphere of cerebellum, secondary oocyte, superior frontal gyrus, sural nerve, ventral tegmental area, zygote
RNA expression pattern · 19
HERC2 → anterior pituitary, cerebellar cortex, corpus callosum, dentate gyrus of hippocampal formation granule cell, medial dorsal nucleus, medial vestibular nucleus, muscle layer of sigmoid colon, muscle of thigh, neural layer of retina, pituitary gland, prefrontal cortex, primary visual cortex, right frontal lobe, right hemisphere of cerebellum, secondary oocyte, superior frontal gyrus, sural nerve, ventral tegmental area, zygote
related to Clinical significance · 14
HERC2 → Angelman, AS, E6AP, E6AP E3, HER2, In, In Old Order Amish, Its, OCA2, RLD, Similar, The, These, While
related to Pigmentation · 12
HERC2 → Americas, Europe, In, Near East, Nonetheless, North Africa, OCA2, Oceania, SNP, SNPs, The, This
related to Protein structure · 12
HERC2 → DNA, E3, HECT, HERC, In, It, N-terminal, RLD, SUMOylation, This, While, ZZ-type
related to DNA repair pathways · 8
HERC2 → Chk1, Chk1-directed DNA, DNA, It, Regulating DNA, This, Under, USP20
related to Gene locus · 6
HERC2 → At, CpG, OCA2, SNPs, The, This
related to Iron metabolism · 5
HERC2 → Depletion, F-box, FBXL5, IR2, Iron
related to Evolution · 3
HERC2 → Caucasus, Italy, The HERC2

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

dna protein gene repair associated bp also human ligase 15 expression rld chr band chromosome cellular damage domain oca2 hect

HERC2 relationships Subject–Predicate–Object triples

TTTA extracted 153 structured relationships around HERC2. Examples in this analysis include HERC2 → 2.3.2.26 → ↗ and HERC2 → Aliases → HERC2, p528, D15F37S1, MRT38, SHEP1, jdf2, HECT and RLD domain containing E3 ubiquitin protein ligase 2, LOC107987422. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
HERC22.3.2.261.00infobox
HERC2AliasesHERC2, p528, D15F37S1, MRT38, SHEP1, jdf2, HECT and RLD domain containing E3 ubiquitin protein ligase 2, LOC1079874221.00infobox
HERC2Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2KEO, 3KCI, 4L1M1.00infobox
HERC2Band15q13.11.00infobox
HERC2Band7 B5|7 33.42 cM1.00infobox
HERC2Bgeesural nerve1.00infobox
HERC2Bgeeright hemisphere of cerebellum1.00infobox
HERC2Bgeepituitary gland1.00infobox
HERC2Bgeecorpus callosum1.00infobox
HERC2Bgeemuscle layer of sigmoid colon1.00infobox
HERC2Bgeeanterior pituitary1.00infobox
HERC2Bgeesuperior frontal gyrus1.00infobox
HERC2Bgeeright frontal lobe1.00infobox
HERC2Bgeeprefrontal cortex1.00infobox
HERC2Bgeeprimary visual cortex1.00infobox
HERC2Bgeesecondary oocyte1.00infobox
HERC2Bgeedentate gyrus of hippocampal formation granule cell1.00infobox
HERC2Bgeeneural layer of retina1.00infobox
HERC2Bgeezygote1.00infobox
HERC2Bgeemedial dorsal nucleus1.00infobox
HERC2Bgeemuscle of thigh1.00infobox
HERC2Bgeeventral tegmental area1.00infobox
HERC2Bgeecerebellar cortex1.00infobox
HERC2Bgeemedial vestibular nucleus1.00infobox
HERC2BioGPSMore reference expression data1.00infobox
HERC2Chr.Chromosome 15 (human)1.00infobox
HERC2Chr.Chromosome 7 (mouse)1.00infobox
HERC2DatabasesNCBI: entry; OMA: entry1.00infobox
HERC2End28,322,179 bp1.00infobox
HERC2End55,881,548 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around HERC2 bring nearby vocabulary together. In this analysis, examples include Expression, Gene and Associated. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • HERC2
    • Expression
    • Gene
    • Associated
    • Protein
    • Oca2
    • Also
    • Repair
    • Dna
    • P53
    • Ubiquitin
    • Ligase
    • Activity
  • herc2
    • Expression
    • Gene
    • Associated
    • Protein
    • Oca2
    • Also
    • Repair
    • Dna
    • P53
    • Ubiquitin
    • Ligase
    • Activity
  • e3 ubiquitin protein ligase
    • Ligase
    • Ubiquitin
    • Hect
    • Rld
    • Locus
    • Activity
    • Location
    • Pigmentation
    • Binding
    • E3
    • Protein
    • Repair
  • hect domains
    • Rld
    • E3
    • Domain
    • Ligase
    • Domains
    • Hect
    • Pigmentation
    • Ubiquitin
    • Protein
    • Gene
    • Repair
    • Activity
  • dna polymerase
    • Repair
    • Damage
    • Pathways
    • Protein
    • Involved
    • Ubiquitin
    • Ligase
    • Activity
    • Location
    • Pigmentation
    • Binding
    • E3
  • centrosome
    • Activity
    • Location
    • Pigmentation
    • Binding
    • E3
    • Hect
    • Implicated
    • Locus
    • Pathways
    • Ubiquitin
    • Bp
    • Chr
  • gene locus
    • Human
    • Location
    • Expression
    • Ubiquitin
    • Bp
    • Chr
    • Chromosome
    • Oca2
    • Activity
    • Protein
    • Band
    • Hect
  • protein function
    • Ubiquitin
    • Repair
    • Iron
    • Rld
    • Ligase
    • Gene
    • Activity
    • Location
    • Pigmentation
    • Binding
    • Involved
    • Locus

Connections between topic areas Semantic bridges

For HERC2, one of the stronger structural bridges in this analysis connects HERC2 with Protein function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
HERC2Protein function · splits 31 ⟂ 23
HERC2Gene locus · splits 47 ⟂ 7
HERC2Clinical significance · splits 47 ⟂ 7
HERC2Interactions · splits 47 ⟂ 7
HERC2Overview · splits 48 ⟂ 6
HERC2History · splits 51 ⟂ 3

Map overview Semantic statistics

HERC2

Nodes54
Edges53
Triples153
Avg. degree1.96
Density0.037037
Components1

Source & methodology

TTTA analyzes the structure around HERC2 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History, Products & Standards, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — HERC2 · EN edition · Analysis: TopicsToTalkAbout

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