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HERC2, or HECT and RLD domain containing E3 ubiquitin protein ligase 2, is a giant E3 ubiquitin protein ligase, implicated in DNA repair regulation, pigmentation and neurological disorders. It is encoded by a gene of the same name belonging to the HERC family, which typically encodes large protein products with C-terminal HECT domains and one or more…
The analysis highlights History, Products and Standards as prominent areas in the source structure around HERC2.
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
High-confidence facts extracted from structured source data. Use them as anchors for further research.
Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
The extracted context around HERC2 shows recurring relationship patterns in the source. For example, HERC2 → cellular response to DNA damage stimulus, centriole, cytoplasm, cytoskeleton, DNA repair, double-strand break repair via nonhomologous end joining, guanyl-nucleotide exchange factor activity, intracellular protein transport, membrane, metal ion binding, mitochondrial inner membrane, nucleoplasm, nucleus, proteasome-mediated ubiquitin-dependent protein catabolic process, protein binding, protein ubiquitination, regulation of molecular function, spermatogenesis, SUMO binding, transferase activity Another extracted example is HERC2 → anterior pituitary, cerebellar cortex, corpus callosum, dentate gyrus of hippocampal formation granule cell, medial dorsal nucleus, medial vestibular nucleus, muscle layer of sigmoid colon, muscle of thigh, neural layer of retina, pituitary gland, prefrontal cortex, primary visual cortex, right frontal lobe, right hemisphere of cerebellum, secondary oocyte, superior frontal gyrus, sural nerve, ventral tegmental area, zygote. Use these groups to spot repeated connection types before inspecting the individual relationships.
Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.
dna protein gene repair associated bp also human ligase 15 expression rld chr band chromosome cellular damage domain oca2 hect
TTTA extracted 153 structured relationships around HERC2. Examples in this analysis include HERC2 → 2.3.2.26 → ↗ and HERC2 → Aliases → HERC2, p528, D15F37S1, MRT38, SHEP1, jdf2, HECT and RLD domain containing E3 ubiquitin protein ligase 2, LOC107987422. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| HERC2 | 2.3.2.26 | ↗ | 1.00 | infobox |
| HERC2 | Aliases | HERC2, p528, D15F37S1, MRT38, SHEP1, jdf2, HECT and RLD domain containing E3 ubiquitin protein ligase 2, LOC107987422 | 1.00 | infobox |
| HERC2 | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2KEO, 3KCI, 4L1M | 1.00 | infobox |
| HERC2 | Band | 15q13.1 | 1.00 | infobox |
| HERC2 | Band | 7 B5|7 33.42 cM | 1.00 | infobox |
| HERC2 | Bgee | sural nerve | 1.00 | infobox |
| HERC2 | Bgee | right hemisphere of cerebellum | 1.00 | infobox |
| HERC2 | Bgee | pituitary gland | 1.00 | infobox |
| HERC2 | Bgee | corpus callosum | 1.00 | infobox |
| HERC2 | Bgee | muscle layer of sigmoid colon | 1.00 | infobox |
| HERC2 | Bgee | anterior pituitary | 1.00 | infobox |
| HERC2 | Bgee | superior frontal gyrus | 1.00 | infobox |
| HERC2 | Bgee | right frontal lobe | 1.00 | infobox |
| HERC2 | Bgee | prefrontal cortex | 1.00 | infobox |
| HERC2 | Bgee | primary visual cortex | 1.00 | infobox |
| HERC2 | Bgee | secondary oocyte | 1.00 | infobox |
| HERC2 | Bgee | dentate gyrus of hippocampal formation granule cell | 1.00 | infobox |
| HERC2 | Bgee | neural layer of retina | 1.00 | infobox |
| HERC2 | Bgee | zygote | 1.00 | infobox |
| HERC2 | Bgee | medial dorsal nucleus | 1.00 | infobox |
| HERC2 | Bgee | muscle of thigh | 1.00 | infobox |
| HERC2 | Bgee | ventral tegmental area | 1.00 | infobox |
| HERC2 | Bgee | cerebellar cortex | 1.00 | infobox |
| HERC2 | Bgee | medial vestibular nucleus | 1.00 | infobox |
| HERC2 | BioGPS | More reference expression data | 1.00 | infobox |
| HERC2 | Chr. | Chromosome 15 (human) | 1.00 | infobox |
| HERC2 | Chr. | Chromosome 7 (mouse) | 1.00 | infobox |
| HERC2 | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| HERC2 | End | 28,322,179 bp | 1.00 | infobox |
| HERC2 | End | 55,881,548 bp | 1.00 | infobox |
The concept neighborhoods around HERC2 bring nearby vocabulary together. In this analysis, examples include Expression, Gene and Associated. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For HERC2, one of the stronger structural bridges in this analysis connects HERC2 with Protein function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around HERC2 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History, Products & Standards, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — HERC2 · EN edition · Analysis: TopicsToTalkAbout