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Pannexin

Pannexins (from Greek 'παν' — all, and from Latin 'nexus' — connection) are a family of vertebrate proteins identified by their homology to the invertebrate innexins. While innexins are responsible for forming gap junctions in invertebrates, the pannexins have been shown to predominantly exist as large transmembrane channels connecting the intracellular…

Relationship to connexins, Function & Clinical significance

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Topic orientation

Pannexin at a glance

The strongest research directions include Relationship to connexins and Function. Use the connected concepts below as starting points, not as a keyword checklist.

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Explore the main themes, entities and connections around Pannexin. Start with the topic map, then use the sections below for research and deeper semantic analysis.

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Relationship to connexins

7 related topics

Function

6 related topics

Clinical significance

2 related topics

Overview

6 related topics

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

AlphaFold
IPR039099
Available protein structures:
IPR039099
InterPro
IPR039099
PDB
IPR039099
Symbol
Pannexin
TCDB
1.A.25

Topics to explore

A structured outline of related entities, concepts and subtopics. Open any item to build a new map centered on it.

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Overview

Function

Relationship to connexins

Clinical significance

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How this topic connects Entity context

Quick relationship hints grouped by predicate. Useful for spotting recurring semantic connections around the current entity.

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Pannexin

Top relations

related to Function · 10
Pannexin → Activation, ATP, Ca2, Da, ER, Golgi, P2X7, Pannexins, These, They
related to Relationship to connexins · 8
Pannexin → C-terminal, Despite, Intercellular, LRRC8A, PfamPF12534, Structurally, The N-terminal, VRAC-forming LRRC8
related to Clinical significance · 5
Pannexin → ATP, Pannexins, PANX2, Particularly, Truncating
AlphaFold · 1
Pannexin → IPR039099
Available protein structures: · 1
Pannexin → IPR039099
InterPro · 1
Pannexin → IPR039099
PDB · 1
Pannexin → IPR039099
Symbol · 1
Pannexin → Pannexin
TCDB · 1
Pannexin → 1.A.25

Important terminology Word statistics

Frequent words and multi-word phrases across the lead, headings, infobox and body. Useful for terminology coverage.

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

pannexins channels atp connexins innexins pdb proteins shown transmembrane molecules release cells may formed family gap junctions intracellular extracellular allowing

Entity relationships Subject–Predicate–Object triples

Extracted RDF-like relationships with confidence and source. The table includes structured facts and lower-confidence contextual relations.
SubjectPredicateObjectConfidenceSrc
PannexinAlphaFoldIPR0390991.00infobox
PannexinAvailable protein structures:IPR0390991.00infobox
PannexinInterProIPR0390991.00infobox
PannexinPDBIPR0390991.00infobox
PannexinSymbolPannexin1.00infobox
PannexinTCDB1.A.251.00infobox
Pannexinrelated to Clinical significanceTruncating0.60section
Pannexinrelated to Clinical significanceATP0.60section
Pannexinrelated to Clinical significancePannexins0.60section
Pannexinrelated to Clinical significanceParticularly0.60section
Pannexinrelated to Clinical significancePANX20.60section
Pannexinrelated to FunctionPannexins0.60section

Related concept clusters Concept neighborhoods

Clusters of nearby vocabulary surrounding the topic. Scan them for adjacent concepts and language you may have missed.

These clusters group vocabulary that occurs around closely connected concepts in the source material.

    Connections between topic areas Semantic bridges

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    Bridges can reveal useful research angles that are easy to miss in a flat list of related terms.

    Map overview Semantic statistics

    Number of nodes, edges, triples, density and central hubs. Use it to gauge the size and connectivity of the map.

    Pannexin

    Nodes26
    Edges25
    Triples29
    Avg. degree1.92
    Density0.076923
    Components1
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