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Pannexin: Relationship to connexins, Function & Clinical significance

Pannexins (from Greek 'παν' — all, and from Latin 'nexus' — connection) are a family of vertebrate proteins identified by their homology to the invertebrate innexins. While innexins are responsible for forming gap junctions in invertebrates, the pannexins have been shown to predominantly exist as large transmembrane channels connecting the intracellular…

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Pannexin topic overview

The analysis highlights Relationship to connexins, Function and Clinical significance as prominent areas in the source structure around Pannexin.

Related topics: 21
Source areas: 4
Connected nodes: 25
Extracted relationships: 29
Concept neighborhoods: 13
Bridge connections: 25

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Relationship to connexins · 7 topics

Function · 6 topics

Overview · 6 topics

Clinical significance · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

AlphaFold: IPR039099
Available protein structures:: IPR039099
InterPro: IPR039099
PDB: IPR039099
Symbol: Pannexin
TCDB: 1.A.25

Suggested research paths

A focused starting point derived from the topic graph, ranked independently of the source article order.

Start with these areas

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Innexins
Gap junctions
Channels Ion channel
ATP Adenosine triphosphate
Sulforhodamine B
Chordates

Function

Inositol triphosphate Inositol trisphosphate
P2X7 P2RX7
Interleukin-1β IL1B
Hippocampus
Cortex Cerebral cortex
Metabolism

Relationship to connexins

Gap junctions Gap junction
Connexin
Pfam
VRAC Volume-regulated anion channel
LRRC8A
Xenopus tropicalis
PDB Protein Data Bank

Clinical significance

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Pannexin connects Entity context

The extracted context around Pannexin shows recurring relationship patterns in the source. For example, Pannexin → Activation, ATP, Ca2, Da, ER, Golgi, P2X7, Pannexins, These, They Another extracted example is Pannexin → C-terminal, Despite, Intercellular, LRRC8A, PfamPF12534, Structurally, The N-terminal, VRAC-forming LRRC8. Use these groups to spot repeated connection types before inspecting the individual relationships.

Pannexin

Top relations

related to Function · 10

Pannexin → Activation, ATP, Ca2, Da, ER, Golgi, P2X7, Pannexins, These, They

related to Relationship to connexins · 8

Pannexin → C-terminal, Despite, Intercellular, LRRC8A, PfamPF12534, Structurally, The N-terminal, VRAC-forming LRRC8

related to Clinical significance · 5

Pannexin → ATP, Pannexins, PANX2, Particularly, Truncating

AlphaFold · 1

Pannexin → IPR039099

Available protein structures: · 1

Pannexin → IPR039099

InterPro · 1

Pannexin → IPR039099

PDB · 1

Pannexin → IPR039099

Symbol · 1

Pannexin → Pannexin

TCDB · 1

Pannexin → 1.A.25

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

pannexins channels atp connexins innexins pdb proteins shown transmembrane molecules release cells may formed family gap junctions intracellular extracellular allowing

Pannexin relationships Subject–Predicate–Object triples

TTTA extracted 29 structured relationships around Pannexin. Examples in this analysis include Pannexin → AlphaFold → IPR039099 and Pannexin → Symbol → Pannexin. The table shows each extracted connection, where it came from and its confidence.

Subject	Predicate	Object	Confidence	Src
Pannexin	AlphaFold	IPR039099	1.00	infobox
Pannexin	Available protein structures:	IPR039099	1.00	infobox
Pannexin	InterPro	IPR039099	1.00	infobox
Pannexin	PDB	IPR039099	1.00	infobox
Pannexin	Symbol	Pannexin	1.00	infobox
Pannexin	TCDB	1.A.25	1.00	infobox
Pannexin	related to Clinical significance	Truncating	0.60	section
Pannexin	related to Clinical significance	ATP	0.60	section
Pannexin	related to Clinical significance	Pannexins	0.60	section
Pannexin	related to Clinical significance	Particularly	0.60	section
Pannexin	related to Clinical significance	PANX2	0.60	section
Pannexin	related to Function	Pannexins	0.60	section

Related concept clusters Concept neighborhoods

The concept neighborhoods around Pannexin bring nearby vocabulary together. In this analysis, examples include Release, Channel and P2x7. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

channels
- Connexins
- Probenecid
- Formed
- Molecules
- Transmembrane
- Atp
- Pannexins
- Pannexin
- Allowing
- Extracellular
- Form
- Function
atp
- Release
- Small
- Cells
- Molecules
- Pannexin
- Shown
- Channels
- Channel
- Connexin
- Extracellular
- Form
- Gap
gap junctions
- Junctions
- Allowing
- Connexin
- Extracellular
- Innexins
- Intracellular
- Small
- Formed
- Molecules
- Proteins
- Shown
- Transmembrane
Pannexin
- Release
- Channel
- P2x7
- Receptor
- Cells
- Pdb
- Shown
- Damage
- Involved
- Protein
- Transport
- Transmembrane
pannexin
- Release
- Channel
- P2x7
- Receptor
- Cells
- Pdb
- Shown
- Damage
- Involved
- Protein
- Transport
- Transmembrane
innexins
- Allowing
- Extracellular
- Gap
- Intracellular
- Junctions
- Small
- Molecules
- Proteins
- Shown
- Transmembrane
- Pannexins
- Atp
relationship to connexins
- Probenecid
- Formed
- Transmembrane
- Pannexins
- Extracellular
- Form
- Function
- Intracellular
- Protein
- Transport
- Molecules
- Pdb
connexin
- Family
- Form
- Gap
- Hemichannels
- Junctions
- Small
- Transport
- Formed
- Molecules
- Proteins

Connections between topic areas Semantic bridges

For Pannexin, one of the stronger structural bridges in this analysis connects Pannexin with Relationship to connexins. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3

Pannexin — Relationship to connexins · splits 18 ⟂ 8

Pannexin — Overview · splits 19 ⟂ 7

Pannexin — Function · splits 19 ⟂ 7

Pannexin — Clinical significance · splits 23 ⟂ 3

Map overview Semantic statistics

Pannexin

Nodes26

Edges25

Triples29

Avg. degree1.92

Density0.076923

Components1

Source & methodology

TTTA analyzes the structure around Pannexin to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Relationship to connexins, Function & Clinical significance, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Pannexin · EN edition · Analysis: TopicsToTalkAbout

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