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Anthrax toxin

Anthrax toxin is a three-protein exotoxin secreted by virulent strains of the bacterium, Bacillus anthracis—the causative agent of anthrax. The toxin was first discovered by Harry Smith in 1954. Anthrax toxin is composed of a cell-binding protein, known as protective antigen (PA), and two enzyme components, called edema factor (EF) and lethal factor…

Mechanism of action, Overview & Bacillus anthracis virulence factors

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Mechanism of action

A-B toxinEnzymesAnthrax toxin receptorEndotheliumTEM8
20 related topics

Overview

ProteinExotoxinVirulentBacteriumBacillus anthracis
20 related topics

Bacillus anthracis virulence factors

Gram positivePolyglutamic acidPhagocyticProteinEdema
5 related topics

Extracellular toxin structure-function relationship

Β-hairpinCholesterolLipid raftsDynaminClathrin
5 related topics

Key facts & relationships

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AlphaFold
IPR015239 · PF09156
Available protein structures:
IPR015239 · PF09156
InterPro
IPR015239
OPM superfamily
35
PDB
IPR015239 PF09156 (ECOD; PDBsum)
Pfam
PF09156

Topics to explore

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Overview

Bacillus anthracis virulence factors

Mechanism of action

Extracellular toxin structure-function relationship

Structure-function relationship from vesicle to cytosol

Advanced semantic analysis

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Map overview Semantic statistics

Anthrax toxin

Nodes61
Edges60
Triples67
Avg. degree1.97
Density0.032787
Components1

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Anthrax toxin

Top relations

related to Anthrax toxin assembly and translocation · 18
Anthrax toxin → Anthrax, CMG2, EF, Fig, In, LF, PA, PA20, PA63, PA83, PA83's, TEM8, The, Then, There, This, Through, When PA20
related to Extracellular toxin structure-function relationship · 16
Anthrax toxin → Analyses, ANTXR1, ANTXR2, CMG2, EF, Fig, Figs, LF, MIDAS, PA, Structures, Table, TEM8, The, These, This
related to Mechanism of action · 13
Anthrax toxin → A-B, A2B, Anthrax, Each, EF, It, LF, Once, PA, The, The PA, Thus, Toxic
related to Bacillus anthracis virulence factors · 8
Anthrax toxin → Anthrax, Bacillus, EF, Fig, Gram, LF, PA, The
AlphaFold · 2
Anthrax toxin → IPR015239, PF09156
Available protein structures: · 2
Anthrax toxin → IPR015239, PF09156
is a · 2
Anthrax toxin → mixture of three protein components, three-protein exotoxin secreted by virulent strains of the bacterium
InterPro · 1
Anthrax toxin → IPR015239
OPM superfamily · 1
Anthrax toxin → 35
PDB · 1
Anthrax toxin → IPR015239 PF09156 (ECOD; PDBsum)

Important terminology Word statistics

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Important terminology

pa toxin lf ef protein anthrax pore ph cell cmg2 domain greek-key components structure membrane heptamer formation pa63 cytosol endocytosis

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Anthrax toxinAlphaFoldIPR0152391.00infobox
Anthrax toxinAlphaFoldPF091561.00infobox
Anthrax toxinAvailable protein structures:IPR0152391.00infobox
Anthrax toxinAvailable protein structures:PF091561.00infobox
Anthrax toxinInterProIPR0152391.00infobox
Anthrax toxinOPM superfamily351.00infobox
Anthrax toxinPDBIPR015239 PF09156 (ECOD; PDBsum)1.00infobox
Anthrax toxinPfamPF091561.00infobox
Anthrax toxinSCOP21j7n / SCOPe / SUPFAM1.00infobox
Anthrax toxinSymbolAnthrax-tox_M1.00infobox
Anthrax toxinis athree-protein exotoxin secreted by virulent strains of the bacterium0.90text
Anthrax toxinis amixture of three protein components0.90text

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