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FKBP

The FKBPs, or FK506 binding proteins, constitute a family of proteins that have prolyl isomerase activity and are related to the cyclophilins in function, though not in amino acid sequence. FKBPs have been identified in many eukaryotes, ranging from yeast to humans, and function as protein folding chaperones for proteins containing proline residues.…

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Examples

AIPAIPL1FKBPLFKBP1BFKBP2
16 related topics

Overview

FK506ProteinsProlyl isomeraseCyclophilinsAmino acid sequence
22 related topics

Use as a biological research tool

FK1012Chemically induced dimerization
2 related topics

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

AlphaFold
IPR001179 · PF00254
Available protein structures:
IPR001179 · PF00254
InterPro
IPR001179
Membranome
336
PDB
IPR001179 PF00254 (ECOD; PDBsum)
Pfam
PF00254

Topics to explore

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Overview

Use as a biological research tool

Examples

Advanced semantic analysis

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Map overview Semantic statistics

FKBP

Nodes44
Edges43
Triples33
Avg. degree1.95
Density0.045455
Components1

How this topic connects Entity context

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FKBP

Top relations

related to Examples · 18
FKBP → AIP, AIPL1FKBPL, FKBP10, FKBP11, FKBP14, FKBP15, FKBP1A, FKBP1B, FKBP1C, FKBP2, FKBP3, FKBP4, FKBP5, FKBP6, FKBP7, FKBP8, FKBP9, Human
related to Use as a biological research tool · 4
FKBP → FK1012, FK506, FKBP1A, This
AlphaFold · 2
FKBP → IPR001179, PF00254
Available protein structures: · 2
FKBP → IPR001179, PF00254
InterPro · 1
FKBP → IPR001179
Membranome · 1
FKBP → 336
PDB · 1
FKBP → IPR001179 PF00254 (ECOD; PDBsum)
Pfam · 1
FKBP → PF00254
PROSITE · 1
FKBP → PDOC00426
SCOP2 · 1
FKBP → 1fkb / SCOPe / SUPFAM

Important terminology Word statistics

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Important terminology

protein tacrolimus fk506 fkbps related proteins humans family fkbp1a binding prolyl isomerase activity function cyclophilin organ binds role also fkbp12

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
FKBPAlphaFoldIPR0011791.00infobox
FKBPAlphaFoldPF002541.00infobox
FKBPAvailable protein structures:IPR0011791.00infobox
FKBPAvailable protein structures:PF002541.00infobox
FKBPInterProIPR0011791.00infobox
FKBPMembranome3361.00infobox
FKBPPDBIPR001179 PF00254 (ECOD; PDBsum)1.00infobox
FKBPPfamPF002541.00infobox
FKBPPROSITEPDOC004261.00infobox
FKBPSCOP21fkb / SCOPe / SUPFAM1.00infobox
FKBPSymbolFKBP_C1.00infobox
FKBPrelated to ExamplesHuman0.60section

Related concept clusters Concept neighborhoods

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    Connections between topic areas Semantic bridges

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    Min side: 3
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