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Ischemic cascade

The ischemic (ischaemic) cascade is a series of biochemical reactions that are initiated in the brain and other aerobic tissues after seconds to minutes of ischemia (inadequate blood supply). This is typically secondary to stroke, injury, or cardiac arrest due to heart attack. Most ischemic neurons that die do so due to the activation of chemicals…

Art, Mechanism & Mitigation of effects

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Ischemic cascade

Nodes50
Edges49
Triples40
Avg. degree1.96
Density0.04
Components1

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Ischemic cascade

Top relations

related to Mechanism · 27
Ischemic cascade → Acquired Mitochondropathy-A New Paradigm, AMPA, An, As, ATP, ATP-reliant, ATPases, Ca2, Calcium, Cerebral, Despite, Diseases, Excess, Freye, Glutamate, Harmful, If, In, Low, Mitochondria
has effect · 9
Ischemic cascade → Actilyse, Activase, Alteplase, Japan, Over, PA, Radicut, The, US

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Important terminology

cascade ischemic blood cell calcium brain glutamate chemicals cells due ischemia tissue flow neurons one causes harmful series initiated tissues

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
calpaininstance ofreactive oxygen species and calcium-dependent enzymes0.80text
endonucleasesinstance ofreactive oxygen species and calcium-dependent enzymes0.80text
ATPasesinstance ofreactive oxygen species and calcium-dependent enzymes0.80text
and phospholipases in a process called excitotoxicityinstance ofreactive oxygen species and calcium-dependent enzymes0.80text
Ischemic cascadehas effectThe0.60section
Ischemic cascadehas effectOver0.60section
Ischemic cascadehas effectPA0.60section
Ischemic cascadehas effectActivase0.60section
Ischemic cascadehas effectAlteplase0.60section
Ischemic cascadehas effectActilyse0.60section
Ischemic cascadehas effectUS0.60section
Ischemic cascadehas effectRadicut0.60section

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