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The serine/threonine-protein kinase/endoribonuclease inositol-requiring enzyme 1 α (IRE1α) is an enzyme that in humans is encoded by the ERN1 gene.
The analysis highlights Specific roles in the brain, Signaling and Clinical significance as prominent areas in the source structure around ERN1.
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
High-confidence facts extracted from structured source data. Use them as anchors for further research.
Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
The extracted context around ERN1 shows recurring relationship patterns in the source. For example, ERN1 → ADP binding, AIP1-IRE1 complex, apoptotic process, ATP binding, catalytic activity, cellular response to glucose stimulus, cellular response to vascular endothelial growth factor stimulus, cytoplasm, endonuclease activity, endoplasmic reticulum, endoplasmic reticulum membrane, endoplasmic reticulum unfolded protein response, endoribonuclease activity, endothelial cell proliferation, enzyme binding, Hsp70 protein binding, Hsp90 protein binding, hydrolase activity, identical protein binding, insulin metabolic process Another extracted example is ERN1 → adrenal gland, amniotic fluid, body of pancreas, caput epididymis, decidua, gastrula, germinal epithelium, lacrimal gland, left adrenal cortex, parotid gland, primary oocyte, right adrenal cortex, secondary oocyte, seminal vesicula, submandibular gland, zygote. Use these groups to spot repeated connection types before inspecting the individual relationships.
Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.
ire1α gene kinase bp protein human chr band activity chromosome 17 enzyme ire1 endoplasmic rnase domain signaling unfolded response stress
TTTA extracted 122 structured relationships around ERN1. Examples in this analysis include ERN1 → 2.7.11.1 → ↗ and ERN1 → Aliases → ERN1, IRE1, IRE1P, IRE1a, hIRE1p, endoplasmic reticulum to nucleus signaling 1. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| ERN1 | 2.7.11.1 | ↗ | 1.00 | infobox |
| ERN1 | Aliases | ERN1, IRE1, IRE1P, IRE1a, hIRE1p, endoplasmic reticulum to nucleus signaling 1 | 1.00 | infobox |
| ERN1 | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2HZ6, 3P23, 4U6R, 4Z7G, 4Z7H, 4YZC, 4YZ9, 4YZD, 5HGI | 1.00 | infobox |
| ERN1 | Band | 17q23.3 | 1.00 | infobox |
| ERN1 | Band | 11|11 E1 | 1.00 | infobox |
| ERN1 | Bgee | parotid gland | 1.00 | infobox |
| ERN1 | Bgee | decidua | 1.00 | infobox |
| ERN1 | Bgee | amniotic fluid | 1.00 | infobox |
| ERN1 | Bgee | secondary oocyte | 1.00 | infobox |
| ERN1 | Bgee | right adrenal cortex | 1.00 | infobox |
| ERN1 | Bgee | seminal vesicula | 1.00 | infobox |
| ERN1 | Bgee | left adrenal cortex | 1.00 | infobox |
| ERN1 | Bgee | body of pancreas | 1.00 | infobox |
| ERN1 | Bgee | caput epididymis | 1.00 | infobox |
| ERN1 | Bgee | germinal epithelium | 1.00 | infobox |
| ERN1 | Bgee | primary oocyte | 1.00 | infobox |
| ERN1 | Bgee | gastrula | 1.00 | infobox |
| ERN1 | Bgee | lacrimal gland | 1.00 | infobox |
| ERN1 | Bgee | submandibular gland | 1.00 | infobox |
| ERN1 | Bgee | adrenal gland | 1.00 | infobox |
| ERN1 | Bgee | zygote | 1.00 | infobox |
| ERN1 | BioGPS | More reference expression data | 1.00 | infobox |
| ERN1 | Chr. | Chromosome 17 (human) | 1.00 | infobox |
| ERN1 | Chr. | Chromosome 11 (mouse) | 1.00 | infobox |
| ERN1 | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| ERN1 | End | 64,130,819 bp | 1.00 | infobox |
| ERN1 | End | 106,378,678 bp | 1.00 | infobox |
| ERN1 | Ensembl | ENSG00000178607 | 1.00 | infobox |
| ERN1 | Entrez | 2081 | 1.00 | infobox |
| ERN1 | Enzyme activity | Enzyme activityEC #BRENDAExPASyKEGGMetaCyc2.7.11.1↗↗↗↗ | 1.00 | infobox |
The concept neighborhoods around ERN1 bring nearby vocabulary together. In this analysis, examples include Search, Serine and Signaling. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For ERN1, one of the stronger structural bridges in this analysis connects ERN1 with Specific roles in the brain. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around ERN1 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Specific roles in the brain, Signaling & Clinical significance, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — ERN1 · EN edition · Analysis: TopicsToTalkAbout