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XBP1

X-box binding protein 1, also known as XBP1, is a protein which in humans is encoded by the XBP1 gene. The XBP1 gene is located on chromosome 22 while a closely related pseudogene has been identified and localized to chromosome 5. The XBP1 protein is a transcription factor that regulates the expression of genes important to the proper functioning of the…

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Aliases
XBP1, TREB5, XBP-1, XBP2, TREB-5, X-box binding protein 1
Band
22q12.1|22q12 · 11 A1|11 3.61 cM
Bgee
body of pancreas · trachea · islet of Langerhans · olfactory zone of nasal mucosa · right lobe of liver
BioGPS
More reference expression data
Chr.
Chromosome 22 (human) · Chromosome 11 (mouse)
Databases
NCBI: entry; OMA: entry

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Map overview Semantic statistics

XBP1

Nodes52
Edges51
Triples225
Avg. degree1.96
Density0.038462
Components1

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XBP1

Top relations

Gene ontology · 116
XBP1 → adipose tissue development, angiogenesis, apoptotic process, ATF6-mediated unfolded protein response, autophagy, cell differentiation, cell growth, cellular response to amino acid stimulus, cellular response to fluid shear stress, cellular response to fructose stimulus, cellular response to glucose starvation, cellular response to glucose stimulus, cellular response to insulin stimulus, cellular response to interleukin-4, cellular response to laminar fluid shear stress, cellular response to leukemia inhibitory factor, cellular response to lipopolysaccharide, cellular response to nutrient, cellular response to oxidative stress, cellular response to peptide hormone stimulus
Bgee · 19
XBP1 → appendix, body of pancreas, bone marrow cell, epithelium of bronchus, epithelium of stomach, gastrula, islet of Langerhans, lacrimal gland, lobe of prostate, olfactory zone of nasal mucosa, parotid gland, rectum, right lobe of liver, right lung lobe, seminal vesicula, submandibular gland, tonsil, trachea, vestibular membrane of cochlear duct
RNA expression pattern · 19
XBP1 → appendix, body of pancreas, bone marrow cell, epithelium of bronchus, epithelium of stomach, gastrula, islet of Langerhans, lacrimal gland, lobe of prostate, olfactory zone of nasal mucosa, parotid gland, rectum, right lobe of liver, right lung lobe, seminal vesicula, submandibular gland, tonsil, trachea, vestibular membrane of cochlear duct
related to Endoplasmic reticulum stress response · 15
XBP1 → Activated IRE1, As, Conditions, ER, GRP78, HAC1, IRE1, It, Moreover, Removal, UPR, XBP-1s, XBP1-unspliced/XBP1-spliced, XBP1u, XBP1u/XBP1s
related to Clinical significance · 8
XBP1 → Abnormalities, Alzheimer's, C116G, Crohn's, DNA-damage, ER, In, None
related to MHC class II gene regulation · 6
XBP1 → Furthermore, IGHM, II, IL-4, IL-6, The
related to Plasma cell differentiation · 6
XBP1 → Blimp1, IRF4, This, Without, XBP1-lacking, XBP1s
related to Viral replication · 6
XBP1 → Epstein Barr, Human T-lymphotropic, Kaposi's, The, This, XBP1s
related to Discovery · 5
XBP1 → DR, HLA, It, The X-box, Xbox
Band · 2
XBP1 → 11 A1|11 3.61 cM, 22q12.1|22q12

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Important terminology

protein gene stress response expression differentiation human cell bp plasma chromosome 22 transcription chr band also factor binding promoter endoplasmic

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
XBP1AliasesXBP1, TREB5, XBP-1, XBP2, TREB-5, X-box binding protein 11.00infobox
XBP1Band22q12.1|22q121.00infobox
XBP1Band11 A1|11 3.61 cM1.00infobox
XBP1Bgeebody of pancreas1.00infobox
XBP1Bgeetrachea1.00infobox
XBP1Bgeeislet of Langerhans1.00infobox
XBP1Bgeeolfactory zone of nasal mucosa1.00infobox
XBP1Bgeeright lobe of liver1.00infobox
XBP1Bgeebone marrow cell1.00infobox
XBP1Bgeetonsil1.00infobox
XBP1Bgeerectum1.00infobox
XBP1Bgeeepithelium of bronchus1.00infobox
XBP1Bgeeappendix1.00infobox
XBP1Bgeelacrimal gland1.00infobox
XBP1Bgeeparotid gland1.00infobox
XBP1Bgeeseminal vesicula1.00infobox
XBP1Bgeesubmandibular gland1.00infobox
XBP1Bgeeepithelium of stomach1.00infobox
XBP1Bgeegastrula1.00infobox
XBP1Bgeeright lung lobe1.00infobox
XBP1Bgeelobe of prostate1.00infobox
XBP1Bgeevestibular membrane of cochlear duct1.00infobox
XBP1BioGPSMore reference expression data1.00infobox
XBP1Chr.Chromosome 22 (human)1.00infobox
XBP1Chr.Chromosome 11 (mouse)1.00infobox
XBP1DatabasesNCBI: entry; OMA: entry1.00infobox
XBP1End28,800,597 bp1.00infobox
XBP1End5,475,893 bp1.00infobox
XBP1EnsemblENSG000001002191.00infobox
XBP1Entrez74941.00infobox

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