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Topic orientation
Prostaglandin EP4 receptor at a glance
The strongest research directions include Expression and Mechanism of cell activation. Use the connected concepts below as starting points, not as a keyword checklist.
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Explore the main themes, entities and connections around Prostaglandin EP4 receptor. Start with the topic map, then use the sections below for research and deeper semantic analysis.
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Start with a few of the strongest sections from the source topic. These are research directions, not a list of keywords you must use.
Expression
20 related topics
Mechanism of cell activation
30 related topics
Functions
Ductus arteriosus#Disorder: Patent ductus arteriosusKnockout mouseFetusReceptor agonistsReceptor antagonists
46 related topics
Clinical significance
Translational researchPhase 2Food and Drug AdministrationSingle nucleotide polymorphismAnkylosing spondylitis
19 related topics
Key facts & relationships
High-confidence facts extracted from structured source data. Use them as anchors for further research.
- Aliases
- PTGER4, EP4, EP4R, EP4 receptor, prostaglandin E receptor 4
- Band
- 5p13.1 · 15 A1|15 1.99 cM
- Bgee
- palpebral conjunctiva · jejunal mucosa · glomerulus · mucosa of sigmoid colon · metanephric glomerulus
- BioGPS
- n/a
- Chr.
- Chromosome 5 (human) · Chromosome 15 (mouse)
- Databases
- NCBI: entry; OMA: entry
Topics to explore
A structured outline of related entities, concepts and subtopics. Open any item to build a new map centered on it.Browse the full topic structure. Each item opens a new analysis centered on that subject.
Overview
Gene
- G protein-coupled receptor
- Rhodopsin-like receptors#Subfamily A14 Rhodopsin-like receptors
Expression
- MRNA
- Northern blotting Northern blot
- Dorsal root ganglions Dorsal root ganglion
- Immunochemistry
- Glomeruli Glomerulus (kidney)
- Tunica media
- Corpus cavernosum of the penis Corpus cavernosum penis
- Carotid artery
- Atherosclerotic plaques Atherosclerotic plaque
- Abdominal aorta
- Aneurysms Aneurysm
- Corneal Cornea
- Keratocytes Keratocyte
- Trabecular cells Trabecular meshwork
- Ciliary Cilia
- Conjunctival Conjunctiva
- Stromal Stroma (tissue)
- Iridal Iris (anatomy)
- Stromal Stroma of iris
- Gingival Gingiva
Ligands
- Prostanoids Prostanoid
- PGF2α PGF2 alpha
- PGI2
- PGD2
- TXA2
- Prostaglandin E1
- Double bond
- Ki=3 nM Dissociation constant
- Ulcerative colitis
- Alzheimer's disease
- Osteoporosis
- Cardiovascular diseases Cardiovascular disease
- Receptor antagonists Receptor antagonist
Mechanism of cell activation
- G proteins
- Gs alpha subunit
- Gβγ complex G beta-gamma complex
- Cell signaling
- Adenyl cyclase
- CAMP Cyclic adenosine monophosphate
- PKA Protein kinase A
- Kinase
- CREB
- C-fos
- Somatostatin
- Corticotropin-releasing hormone
- Cellular proliferation
- Cellular differentiation
- Angiogenesis
- PI3K/AKT/mTOR PI3K/AKT/mTOR pathway
- ERK Extracellular signal-regulated kinases
- P38 MAPK P38 mitogen-activated protein kinases
- EGR1
- Mitogenesis
- P105 Proteasome
- Nuclear factor kappa B
- NF-κB#Structure NF-κB
- EP2 Prostaglandin EP2 receptor
- EP1 Prostaglandin EP1 receptor
- EP3 Prostaglandin EP3 receptor
- Gαq Gq alpha subunit
- Homologous desensitization
- Protein kinase C
- Heterologous desensitization
Functions
- Ductus arteriosus#Disorder: Patent ductus arteriosus Ductus arteriosus
- Knockout mouse
- Fetus
- Receptor agonists
- Receptor antagonists
- Nonsteroidal anti-inflammatory drugs Nonsteroidal anti-inflammatory drug
- Indomethacin
- Patent ductus arteriosus
- Transposition of the great arteries
- IL-12p70 Interleukin 12
- IL-23 Interleukin 23
- IL-17 Interleukin 17
- Th17 cells Th17 cell
- T helper cells T helper cell
- Regulatory T cells Regulatory T cell
- Dendritic cells Dendritic cell
- Antigen-presenting cells Antigen-presenting cell
- B cells B cell
- Atherosclerosis
- Apoptosis
- Macrophages Macrophage
- Arteriole
- Capillary
- Allodynia
- Hyperalgesia
- Colitis
- Inflammatory bowel diseases Inflammatory bowel disease
- Duodenum
- Osteoclast
- IL-1beta
Clinical significance
- Translational research
- Phase 2 Clinical trial
- Food and Drug Administration
- Single nucleotide polymorphism
- Ankylosing spondylitis
- Vertebral column
- Genotype
- Non-steroidal anti-inflammatory drug
- Hypersensitivity
- Wheals
- Angioedema
- Urticarial
- PTGER4 gene promoter Promoter (genetics)
- Meta-analysis
- Genome-wide association studies
- Crohn's disease
- Alleles
- Gene desert
- 5'-untranslated region Five prime untranslated region
Advanced semantic analysis
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
How this topic connects Entity context
Quick relationship hints grouped by predicate. Useful for spotting recurring semantic connections around the current entity.See the strongest relationship patterns around the current topic before diving into the raw triples.
Prostaglandin EP4 receptor
Top relations
Gene ontology · 30
Prostaglandin EP4 receptor → adenylate cyclase-activating G protein-coupled receptor signaling pathway, adenylate cyclase-modulating G protein-coupled receptor signaling pathway, bone development, cellular response to mechanical stimulus, cellular response to prostaglandin E stimulus, ERK1 and ERK2 cascade, G protein-coupled receptor activity, G protein-coupled receptor signaling pathway, immune response, inflammatory response, integral component of membrane, intracellular anatomical structure, JNK cascade, membrane, negative regulation of eosinophil extravasation, negative regulation of inflammatory response, negative regulation of integrin activation, plasma membrane, positive regulation of cytosolic calcium ion concentration, positive regulation of inflammatory response
Bgee · 20
Prostaglandin EP4 receptor → atrioventricular valve, blood, bronchial epithelial cell, conjunctival fornix, germinal epithelium, glomerulus, hair follicle, ileum, jejunal mucosa, left colon, mesenteric lymph nodes, metanephric glomerulus, mucosa of sigmoid colon, palpebral conjunctiva, Paneth cell, parietal pleura, renal corpuscle, synovial joint, uterus, visceral pleura
RNA expression pattern · 20
Prostaglandin EP4 receptor → atrioventricular valve, blood, bronchial epithelial cell, conjunctival fornix, germinal epithelium, glomerulus, hair follicle, ileum, jejunal mucosa, left colon, mesenteric lymph nodes, metanephric glomerulus, mucosa of sigmoid colon, palpebral conjunctiva, Paneth cell, parietal pleura, renal corpuscle, synovial joint, uterus, visceral pleura
Band · 2
Prostaglandin EP4 receptor → 15 A1|15 1.99 cM, 5p13.1
Chr. · 2
Prostaglandin EP4 receptor → Chromosome 15 (mouse), Chromosome 5 (human)
End · 2
Prostaglandin EP4 receptor → 40,693,735 bp, 5,273,668 bp
Aliases · 1
Prostaglandin EP4 receptor → PTGER4, EP4, EP4R, EP4 receptor, prostaglandin E receptor 4
BioGPS · 1
Prostaglandin EP4 receptor → n/a
Databases · 1
Prostaglandin EP4 receptor → NCBI: entry; OMA: entry
Ensembl · 1
Prostaglandin EP4 receptor → ENSG00000171522
Important terminology Word statistics
Frequent words and multi-word phrases across the lead, headings, infobox and body. Useful for terminology coverage.Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.
Important terminology
ep4 receptor gene mice activation human cells prostaglandin studies also ptger4 pge2 humans ductus development cell selective disease may receptors
Entity relationships Subject–Predicate–Object triples
Extracted RDF-like relationships with confidence and source. The table includes structured facts and lower-confidence contextual relations.| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| Prostaglandin EP4 receptor | Aliases | PTGER4, EP4, EP4R, EP4 receptor, prostaglandin E receptor 4 | 1.00 | infobox |
| Prostaglandin EP4 receptor | Band | 5p13.1 | 1.00 | infobox |
| Prostaglandin EP4 receptor | Band | 15 A1|15 1.99 cM | 1.00 | infobox |
| Prostaglandin EP4 receptor | Bgee | palpebral conjunctiva | 1.00 | infobox |
| Prostaglandin EP4 receptor | Bgee | jejunal mucosa | 1.00 | infobox |
| Prostaglandin EP4 receptor | Bgee | glomerulus | 1.00 | infobox |
| Prostaglandin EP4 receptor | Bgee | mucosa of sigmoid colon | 1.00 | infobox |
| Prostaglandin EP4 receptor | Bgee | metanephric glomerulus | 1.00 | infobox |
| Prostaglandin EP4 receptor | Bgee | bronchial epithelial cell | 1.00 | infobox |
| Prostaglandin EP4 receptor | Bgee | visceral pleura | 1.00 | infobox |
| Prostaglandin EP4 receptor | Bgee | synovial joint | 1.00 | infobox |
| Prostaglandin EP4 receptor | Bgee | germinal epithelium | 1.00 | infobox |
| Prostaglandin EP4 receptor | Bgee | parietal pleura | 1.00 | infobox |
| Prostaglandin EP4 receptor | Bgee | renal corpuscle | 1.00 | infobox |
| Prostaglandin EP4 receptor | Bgee | hair follicle | 1.00 | infobox |
| Prostaglandin EP4 receptor | Bgee | conjunctival fornix | 1.00 | infobox |
| Prostaglandin EP4 receptor | Bgee | atrioventricular valve | 1.00 | infobox |
| Prostaglandin EP4 receptor | Bgee | blood | 1.00 | infobox |
| Prostaglandin EP4 receptor | Bgee | mesenteric lymph nodes | 1.00 | infobox |
| Prostaglandin EP4 receptor | Bgee | uterus | 1.00 | infobox |
| Prostaglandin EP4 receptor | Bgee | Paneth cell | 1.00 | infobox |
| Prostaglandin EP4 receptor | Bgee | left colon | 1.00 | infobox |
| Prostaglandin EP4 receptor | Bgee | ileum | 1.00 | infobox |
| Prostaglandin EP4 receptor | BioGPS | n/a | 1.00 | infobox |
| Prostaglandin EP4 receptor | Chr. | Chromosome 5 (human) | 1.00 | infobox |
| Prostaglandin EP4 receptor | Chr. | Chromosome 15 (mouse) | 1.00 | infobox |
| Prostaglandin EP4 receptor | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| Prostaglandin EP4 receptor | End | 40,693,735 bp | 1.00 | infobox |
| Prostaglandin EP4 receptor | End | 5,273,668 bp | 1.00 | infobox |
| Prostaglandin EP4 receptor | Ensembl | ENSG00000171522 | 1.00 | infobox |
No triples extracted yet.
Related concept clusters Concept neighborhoods
Clusters of nearby vocabulary surrounding the topic. Scan them for adjacent concepts and language you may have missed.These clusters group vocabulary that occurs around closely connected concepts in the source material.
Connections between topic areas Semantic bridges
Bridge nodes connect otherwise separate parts of the map. Expand a row to inspect the topic groups on each side.Bridges can reveal useful research angles that are easy to miss in a flat list of related terms.
Map overview Semantic statistics
Number of nodes, edges, triples, density and central hubs. Use it to gauge the size and connectivity of the map.Prostaglandin EP4 receptor
Nodes143
Edges142
Triples102
Avg. degree1.99
Density0.013986
Components1
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