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In cellular biology, durotaxis is a form of cell migration in which cells are guided by rigidity gradients, which arise from differential structural properties of the extracellular matrix (ECM). Most normal cells migrate up rigidity gradients (in the direction of greater stiffness).
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stiffness cell ecm cells focal rigidity collagen migration traction mechanical properties matrix proteins adhesion gradients cytoskeletal tissue adhesions cancer many
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| Durotaxis | is a | form of cell migration in which cells are guided by rigidity gradients | 0.90 | text |
| fibronectin | instance of | and fibrous proteins | 0.80 | text |
| laminin | instance of | and fibrous proteins | 0.80 | text |
| collagen | instance of | and fibrous proteins | 0.80 | text |
| and elastin - it is the latter two fibers that are most influential in defining the mechanical properties of the ECM.Collagen is the fibrous protein that gives the ECM its tensile strength | instance of | and fibrous proteins | 0.80 | text |
| or rigidity | instance of | and fibrous proteins | 0.80 | text |
| the Instron load cell device - that directly apply a mechanical load | instance of | The most precise and well-established method to measure Young's modulus of a tissue relies on instruments - | 0.80 | text |
| measure the resulting deformation | instance of | The most precise and well-established method to measure Young's modulus of a tissue relies on instruments - | 0.80 | text |
| Durotaxis | related to Cancer | It | 0.60 | section |
| Durotaxis | related to Cancer | In | 0.60 | section |
| Durotaxis | related to Cancer | Furthermore | 0.60 | section |
| Durotaxis | related to Cancer | There | 0.60 | section |
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