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Digoxin

Digoxin, sold under the brand name Lanoxin among others, is a medication used to treat various heart conditions. Most frequently it is used for atrial fibrillation, atrial flutter, and heart failure. Digoxin is one of the oldest medications used in the field of cardiology. It works by increasing myocardial contractility, increasing stroke volume and…

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3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
C01AA05 (WHO)
Bioavailability
60 to 80% (by mouth)
CAS Number
20830-75-5 Y
ChEBI
CHEBI:4551 Y

Topics to explore

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Overview

Medical uses

Side effects

Overdose

Pharmacology

History

Society and culture

Digoxin and cancer

Advanced semantic analysis

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Map overview Semantic statistics

Digoxin

Nodes141
Edges140
Triples168
Avg. degree1.99
Density0.014184
Components1

How this topic connects Entity context

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Digoxin

Top relations

related to Brand names · 37
Digoxin → Cardigox, Cardiogoxin, Cardioxin, Cardoxin, Coragoxine, Digacin, Digicor, Digitek, Digomal, Digon, Digosin, Digoxin-Sandoz, Digoxin-Zori, Digoxina-Sandoz, Digoxine Navtivelle, Dilanacin, Eudigox, Fargoxin, Grexin, Lanacordin
related to history · 20
Digoxin → An Account, Arthur Robertson Cushny, Derivatives, Digitalis, Dr, Dropsy, Foxglove, In, Initially, Its, Keller, Medical Uses With Practical, Nicholas Culpeper, Other Diseases, Remarks, Sir James Mackenzie, Sydney Smith, The, The English, William Withering
related to Society and culture · 14
Digoxin → Actavis, Charles Cullen, Class, Digitek, Drug Administration, FDA, Food, Icelandic, Mylan, New Jersey, On April, On March, Pennsylvania, Some
related to Overdose · 8
Digoxin → ATPase-dependent Na/K, Digibind, Digifab, FAB, If, In, The, Therefore
related to Pharmacokinetics · 8
Digoxin → Examples, In, IV, P-glycoprotein, The, United States, Vd, While IV
has effect · 7
Digoxin → ATPase, AV, Gynaecomastia, It, PAT, The, This
related to Heart failure · 7
Digoxin → ACE, Alongside, Digitalis, In, SGLT-2, Since, William Withering
related to Pharmacodynamics · 7
Digoxin → ATPase, Ca2, Digoxin's, Increased, Na, The, This
related to Pharmacomicrobiomics · 6
Digoxin → Eggerthella, Further, North Americans, Southern Indians, The, These
related to Irregular heartbeat · 5
Digoxin → Cardiac, Early, Evidence, However, The

Important terminology Word statistics

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Important terminology

heart also increased used effects patients may cardiac digitalis levels increase failure function drug calcium rate due atrial fibrillation av

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Digoxin3D model (JSmol)Interactive image1.00infobox
DigoxinAHFS/Drugs.comMonograph1.00infobox
DigoxinATC codeC01AA05 (WHO)1.00infobox
DigoxinBioavailability60 to 80% (by mouth)1.00infobox
DigoxinCAS Number20830-75-5 Y1.00infobox
DigoxinChEBICHEBI:4551 Y1.00infobox
DigoxinChEMBLChEMBL1751 Y1.00infobox
DigoxinChemSpider2006532 Y1.00infobox
DigoxinCompTox Dashboard (EPA)DTXSID50229341.00infobox
DigoxinDrugBankDB00390 Y1.00infobox
DigoxinECHA InfoCard100.040.0471.00infobox
DigoxinElimination half-life36 to 48 hours (normal kidney function) 3.5 to 5 days (impaired kidney function)1.00infobox
DigoxinExcretionKidney1.00infobox
DigoxinFormulaC41H64O141.00infobox
DigoxinIUPHAR/BPS47261.00infobox
DigoxinKEGGD00298 Y1.00infobox
DigoxinLegal statusAU: S4 (Prescription only)1.00infobox
DigoxinLegal statusUK: POM (Prescription only)1.00infobox
DigoxinLegal statusUS: ℞-only1.00infobox
DigoxinLicense dataUS DailyMed: Digoxin1.00infobox
DigoxinMedlinePlusa6823011.00infobox
DigoxinMelting point249.3 °C (480.7 °F)1.00infobox
DigoxinMetabolismLiver (16%)1.00infobox
DigoxinMolar mass780.949 g·mol−11.00infobox
DigoxinPDB ligandDGX (PDBe, RCSB PDB)1.00infobox
DigoxinPregnancy categoryAU: A1.00infobox
DigoxinPronunciation/dɪˈdʒɒksɪn/1.00infobox
DigoxinProtein binding25%1.00infobox
DigoxinPubChem CID27243851.00infobox
DigoxinRoutes of administrationBy mouth, intravenous1.00infobox

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