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CXCL9

Chemokine (C-X-C motif) ligand 9 (CXCL9) is a small cytokine belonging to the CXC chemokine family that is also known as monokine induced by gamma interferon (MIG). CXCL9 is one of the chemokines that play a role chemotaxis induction, promote differentiation and multiplication of leukocytes, and cause tissue extravasation.

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Aliases
CXCL9, CMK, Humig, MIG, SCYB9, crg-10, C-X-C motif chemokine ligand 9
Band
4q21.1 · 5 E2|5 46.51 cM
Bgee
appendix · lymph node · epithelium of nasopharynx · superficial temporal artery · rectum
BioGPS
More reference expression data
Chr.
Chromosome 4 (human) · Chromosome 5 (mouse)
Databases
NCBI: entry; OMA: entry

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Function

Clinical significance

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Map overview Semantic statistics

CXCL9

Nodes69
Edges68
Triples154
Avg. degree1.97
Density0.028986
Components1

How this topic connects Entity context

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CXCL9

Top relations

Gene ontology · 33
CXCL9 → adenylate cyclase-activating G protein-coupled receptor signaling pathway, antimicrobial humoral immune response mediated by antimicrobial peptide, cell-cell signaling, cellular defense response, cellular response to lipopolysaccharide, chemokine activity, chemokine-mediated signaling pathway, chemotaxis, CXCR3 chemokine receptor binding, cytokine activity, defense response, defense response to virus, external side of plasma membrane, extracellular region, extracellular space, G protein-coupled receptor signaling pathway, immune response, inflammatory response, intracellular anatomical structure, leukocyte chemotaxis
related to Immune modulation · 22
CXCL9 → An, CXCL9/CXCR3, CXCR3, Foxp3, IL-4, In, M1, M2, Oghumu, RORγ, Several, STAT1, STAT4, STAT5, T-bet, TAM, TAMs, Th1, Th17, TME
Bgee · 20
CXCL9 → appendix, brown adipose tissue, epithelium of nasopharynx, gallbladder, jejunum, left lobe of liver, lymph node, mammary gland, mesenteric lymph nodes, olfactory zone of nasal mucosa, palpebral conjunctiva, parietal pleura, rectum, spleen, subcutaneous adipose tissue, submandibular gland, superficial temporal artery, testicle, tunica adventitia of aorta, white adipose tissue
RNA expression pattern · 20
CXCL9 → appendix, brown adipose tissue, epithelium of nasopharynx, gallbladder, jejunum, left lobe of liver, lymph node, mammary gland, mesenteric lymph nodes, olfactory zone of nasal mucosa, palpebral conjunctiva, parietal pleura, rectum, spleen, subcutaneous adipose tissue, submandibular gland, superficial temporal artery, testicle, tunica adventitia of aorta, white adipose tissue
related to Immune checkpoint regulation · 11
CXCL9 → Additionally, Anti-PD-1, Blockade, CTLA4, CXCL9/CXCR3, IFN-γ, PD-1, PD-L1/PD-1, Peng, Programmed, The
related to Function · 9
CXCL9 → CTLs, IFN-γ, Immune, In, NK, NKT, Th1, The CXCL9/CXCR3, Tumor-infiltrating
related to Structure · 9
CXCL9 → C-terminal, C-termini, C-X-C, Chemokine, CXC, CXCR3, N-terminal, The, This
Band · 2
CXCL9 → 4q21.1, 5 E2|5 46.51 cM
Chr. · 2
CXCL9 → Chromosome 4 (human), Chromosome 5 (mouse)
End · 2
CXCL9 → 76,007,509 bp, 92,475,938 bp

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Important terminology

immune cxcr3 human chemokine tumor cells bp cell chromosome chr band receptor chemokines activation polarization also response differentiation gene location

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
CXCL9AliasesCXCL9, CMK, Humig, MIG, SCYB9, crg-10, C-X-C motif chemokine ligand 91.00infobox
CXCL9Band4q21.11.00infobox
CXCL9Band5 E2|5 46.51 cM1.00infobox
CXCL9Bgeeappendix1.00infobox
CXCL9Bgeelymph node1.00infobox
CXCL9Bgeeepithelium of nasopharynx1.00infobox
CXCL9Bgeesuperficial temporal artery1.00infobox
CXCL9Bgeerectum1.00infobox
CXCL9Bgeeolfactory zone of nasal mucosa1.00infobox
CXCL9Bgeepalpebral conjunctiva1.00infobox
CXCL9Bgeetesticle1.00infobox
CXCL9Bgeegallbladder1.00infobox
CXCL9Bgeeparietal pleura1.00infobox
CXCL9Bgeesubcutaneous adipose tissue1.00infobox
CXCL9Bgeemesenteric lymph nodes1.00infobox
CXCL9Bgeesubmandibular gland1.00infobox
CXCL9Bgeewhite adipose tissue1.00infobox
CXCL9Bgeespleen1.00infobox
CXCL9Bgeeleft lobe of liver1.00infobox
CXCL9Bgeetunica adventitia of aorta1.00infobox
CXCL9Bgeebrown adipose tissue1.00infobox
CXCL9Bgeejejunum1.00infobox
CXCL9Bgeemammary gland1.00infobox
CXCL9BioGPSMore reference expression data1.00infobox
CXCL9Chr.Chromosome 4 (human)1.00infobox
CXCL9Chr.Chromosome 5 (mouse)1.00infobox
CXCL9DatabasesNCBI: entry; OMA: entry1.00infobox
CXCL9End76,007,509 bp1.00infobox
CXCL9End92,475,938 bp1.00infobox
CXCL9EnsemblENSG000001387551.00infobox

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