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CXCL10: Function, Clinical significance & Biomarkers

C-X-C motif chemokine ligand 10 (CXCL10), also known as Interferon gamma-induced protein 10 (IP-10) or small-inducible cytokine B10, is an 8.7 kDa protein that in humans is encoded by the CXCL10 gene. C-X-C motif chemokine 10 is a small cytokine belonging to the CXC chemokine family.

Language: English [EN]
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CXCL10 topic overview

The analysis highlights Function, Clinical significance and Biomarkers as prominent areas in the source structure around CXCL10.

Related topics
33
Source areas
6
Connected nodes
39
Extracted relationships
152
Concept neighborhoods
15
Bridge connections
39

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Function · 12 topics
Clinical significance · 11 topics
Biomarkers · 4 topics
Overview · 4 topics
Gene · 1 topics
Structure · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
CXCL10, C7, IFI10, INP10, IP-10, SCYB10, crg-2, gIP-10, mob-1, C-X-C motif chemokine ligand 10, C-X-C motif chemokine 10
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1O80, 1LV9, 1O7Y, 1O7Z
Band
4q21.1 · 5 E2|5 46.57 cM
Bgee
appendix · testicle · decidua · lymph node · rectum
BioGPS
More reference expression data
Chr.
Chromosome 4 (human) · Chromosome 5 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Gene

Function

Structure

Biomarkers

Clinical significance

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How CXCL10 connects Entity context

The extracted context around CXCL10 shows recurring relationship patterns in the source. For example, CXCL10 → adenylate cyclase-activating G protein-coupled receptor signaling pathway, antimicrobial humoral immune response mediated by antimicrobial peptide, blood circulation, cAMP-dependent protein kinase regulator activity, cell surface receptor signaling pathway, cell-cell signaling, cellular response to heat, cellular response to lipopolysaccharide, chemoattractant activity, chemokine activity, chemokine-mediated signaling pathway, chemotaxis, CXCR3 chemokine receptor binding, cytokine activity, cytokine-mediated signaling pathway, defense response, defense response to virus, endothelial cell activation, external side of plasma membrane, extracellular region Another extracted example is CXCL10 → appendix, decidua, embryo, epithelium of nasopharynx, granulocyte, lymph node, mesenteric lymph nodes, monocyte, olfactory zone of nasal mucosa, optic nerve, rectum, right kidney, smooth muscle tissue, spermatocyte, spleen, subcutaneous adipose tissue, testicle, thymus. Use these groups to spot repeated connection types before inspecting the individual relationships.

CXCL10

Top relations

Gene ontology · 58
CXCL10 → adenylate cyclase-activating G protein-coupled receptor signaling pathway, antimicrobial humoral immune response mediated by antimicrobial peptide, blood circulation, cAMP-dependent protein kinase regulator activity, cell surface receptor signaling pathway, cell-cell signaling, cellular response to heat, cellular response to lipopolysaccharide, chemoattractant activity, chemokine activity, chemokine-mediated signaling pathway, chemotaxis, CXCR3 chemokine receptor binding, cytokine activity, cytokine-mediated signaling pathway, defense response, defense response to virus, endothelial cell activation, external side of plasma membrane, extracellular region
Bgee · 18
CXCL10 → appendix, decidua, embryo, epithelium of nasopharynx, granulocyte, lymph node, mesenteric lymph nodes, monocyte, olfactory zone of nasal mucosa, optic nerve, rectum, right kidney, smooth muscle tissue, spermatocyte, spleen, subcutaneous adipose tissue, testicle, thymus
RNA expression pattern · 18
CXCL10 → appendix, decidua, embryo, epithelium of nasopharynx, granulocyte, lymph node, mesenteric lymph nodes, monocyte, olfactory zone of nasal mucosa, optic nerve, rectum, right kidney, smooth muscle tissue, spermatocyte, spleen, subcutaneous adipose tissue, testicle, thymus
related to Clinical significance · 14
CXCL10 → Alzheimer's, Baseline, CD8, CXCR3, GP63, HCV, HCV RNA, HIV, IP-10, Leishmania, SVR, The, This, Through
related to External links · 10
CXCL10 → C-X-C, C7, Human C7, Human CXCL10, Overview, P02778, PDB, PDBe-KB, UCSC Genome Browser, UniProt
related to Function · 5
CXCL10 → CXCR3, IFN-γ, NK, These, This
Band · 2
CXCL10 → 4q21.1, 5 E2|5 46.57 cM
Chr. · 2
CXCL10 → Chromosome 4 (human), Chromosome 5 (mouse)
End · 2
CXCL10 → 76,023,497 bp, 92,496,748 bp
related to Biomarkers · 2
CXCL10 → CXCL11, CXCL9

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

gene chemokine human bp chr band chromosome location c-x-c motif 10 cytokine cell protein external response ip-10 structure cxcr3 mouse

CXCL10 relationships Subject–Predicate–Object triples

TTTA extracted 152 structured relationships around CXCL10. Examples in this analysis include CXCL10 → Aliases → CXCL10, C7, IFI10, INP10, IP-10, SCYB10, crg-2, gIP-10, mob-1, C-X-C motif chemokine ligand 10, C-X-C motif chemokine 10 and CXCL10 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1O80, 1LV9, 1O7Y, 1O7Z. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
CXCL10AliasesCXCL10, C7, IFI10, INP10, IP-10, SCYB10, crg-2, gIP-10, mob-1, C-X-C motif chemokine ligand 10, C-X-C motif chemokine 101.00infobox
CXCL10Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1O80, 1LV9, 1O7Y, 1O7Z1.00infobox
CXCL10Band4q21.11.00infobox
CXCL10Band5 E2|5 46.57 cM1.00infobox
CXCL10Bgeeappendix1.00infobox
CXCL10Bgeetesticle1.00infobox
CXCL10Bgeedecidua1.00infobox
CXCL10Bgeelymph node1.00infobox
CXCL10Bgeerectum1.00infobox
CXCL10Bgeemonocyte1.00infobox
CXCL10Bgeegranulocyte1.00infobox
CXCL10Bgeeolfactory zone of nasal mucosa1.00infobox
CXCL10Bgeesmooth muscle tissue1.00infobox
CXCL10Bgeeepithelium of nasopharynx1.00infobox
CXCL10Bgeemesenteric lymph nodes1.00infobox
CXCL10Bgeethymus1.00infobox
CXCL10Bgeespleen1.00infobox
CXCL10Bgeespermatocyte1.00infobox
CXCL10Bgeeoptic nerve1.00infobox
CXCL10Bgeeembryo1.00infobox
CXCL10Bgeeright kidney1.00infobox
CXCL10Bgeesubcutaneous adipose tissue1.00infobox
CXCL10BioGPSMore reference expression data1.00infobox
CXCL10Chr.Chromosome 4 (human)1.00infobox
CXCL10Chr.Chromosome 5 (mouse)1.00infobox
CXCL10DatabasesNCBI: entry; OMA: entry1.00infobox
CXCL10End76,023,497 bp1.00infobox
CXCL10End92,496,748 bp1.00infobox
CXCL10EnsemblENSG000001692451.00infobox
CXCL10Entrez36271.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around CXCL10 bring nearby vocabulary together. In this analysis, examples include Gene, Development and Plasma. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • CXCL10
    • Gene
    • Development
    • Plasma
    • Protein
    • Several
    • Response
    • Cell
    • Location
    • Human
    • 1lv9
    • 1o7y
    • 1o80
  • cxcl10
    • Gene
    • Development
    • Plasma
    • Protein
    • Several
    • Response
    • Cell
    • Location
    • Human
    • 1lv9
    • 1o7y
    • 1o80
  • gene
    • Location
    • Human
    • Ucsc
    • Chromosome
    • Bp
    • Chr
    • External
    • Function
    • Ligand
    • Mouse
    • Ip-10
    • Protein
  • cytokine
    • Protein
    • Motif
    • Gene
    • Chemotaxis
    • External
    • Function
    • Ligand
    • Mouse
    • P02778
    • Uniprot
    • Binding
    • Cxcr3
  • chemokine
    • Motif
    • Cytokine
    • Structure
    • Gene
    • External
    • Function
    • Ligand
    • P02778
    • Pdb
    • Uniprot
    • Binding
    • Cxcr3
  • chromosome 4
    • Bp
    • Human
    • Band
    • External
    • Function
    • Location
    • Mouse
    • Gene
    • Structure
    • Chemotaxis
    • Ligand
    • P02778
  • chemokine receptor
    • Motif
    • Cytokine
    • Structure
    • Gene
    • External
    • Function
    • Ligand
    • P02778
    • Pdb
    • Uniprot
    • Binding
    • Cxcr3
  • function
    • External
    • Structure
    • Chromosome
    • Bp
    • Chr
    • Location
    • 1lv9
    • 1o7y
    • 1o80
    • Chemotaxis
    • Gene
    • Human

Connections between topic areas Semantic bridges

For CXCL10, one of the stronger structural bridges in this analysis connects CXCL10 with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
CXCL10Function · splits 27 ⟂ 13
CXCL10Clinical significance · splits 28 ⟂ 12
CXCL10Overview · splits 35 ⟂ 5
CXCL10Biomarkers · splits 35 ⟂ 5

Map overview Semantic statistics

CXCL10

Nodes40
Edges39
Triples152
Avg. degree1.95
Density0.05
Components1

Source & methodology

TTTA analyzes the structure around CXCL10 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Function, Clinical significance & Biomarkers, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — CXCL10 · EN edition · Analysis: TopicsToTalkAbout

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