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Integrase

Retroviral integrase (IN) is an enzyme produced by a retrovirus (such as HIV) that integrates (forms covalent links between) its genetic information into that of the host cell it infects. Retroviral INs are not to be confused with phage integrases (recombinases) used in biotechnology, such as λ phage integrase, as discussed in site-specific recombination.

Technology, Structure & In HIV

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Key facts & relationships

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AlphaFold
IPR003308 · PF02022
Available protein structures:
IPR003308 · PF02022
InterPro
IPR003308
PDB
IPR003308 PF02022 (ECOD; PDBsum)
Pfam
PF02022
SCOP2
1wjb / SCOPe / SUPFAM

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Overview

Structure

Function and mechanism

In HIV

Advanced semantic analysis

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Map overview Semantic statistics

Integrase

Nodes38
Edges37
Triples43
Avg. degree1.95
Density0.052632
Components1

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Integrase

Top relations

related to Integration mechanism · 11
Integrase → DDE, DNA, DNA's, Following, HIV's, Mg2, Mn2, OH, SN2-type, The, Using
related to Antiretroviral therapy · 10
Integrase → August, Drug Administration, Food, HIV, In November, Isentress, MK-0518, On October, Raltegravir, The
related to External links · 6
Integrase → HIV IntegraseIntegrases, Medicine Medical Subject Headings, MeSH, Month, National Library, PDB-101 Molecule
related to In HIV · 5
Integrase → As, C-terminus, HIV, N-terminus, The N-terminus
AlphaFold · 2
Integrase → IPR003308, PF02022
Available protein structures: · 2
Integrase → IPR003308, PF02022
InterPro · 1
Integrase → IPR003308
PDB · 1
Integrase → IPR003308 PF02022 (ECOD; PDBsum)
Pfam · 1
Integrase → PF02022
SCOP2 · 1
Integrase → 1wjb / SCOPe / SUPFAM

Important terminology Word statistics

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Important terminology

viral hiv dna retroviral integration host ends domain catalytic core genome function integrases structure three activity 3' inhibitor complex n-terminus

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
IntegraseAlphaFoldIPR0033081.00infobox
IntegraseAlphaFoldPF020221.00infobox
IntegraseAvailable protein structures:IPR0033081.00infobox
IntegraseAvailable protein structures:PF020221.00infobox
IntegraseInterProIPR0033081.00infobox
IntegrasePDBIPR003308 PF02022 (ECOD; PDBsum)1.00infobox
IntegrasePfamPF020221.00infobox
IntegraseSCOP21wjb / SCOPe / SUPFAM1.00infobox
IntegraseSymbolIntegrase_Zn1.00infobox
Integraseis a32kDa viral protein consisting of three domains- N-terminus0.90text
Mn2instance ofThe specificity of cleavage is improved through the use of cofactors0.80text
Integraserelated to Antiretroviral therapyIn November0.60section

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    Min side: 3
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