CLCN5

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Explore the main themes, entities and connections around CLCN5. Start with the topic map, then use the sections below for research and deeper semantic analysis.

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Localization and function

Tissues Organellar Brain Muscle Intestine

23 related topics

Clinical significance

Allelic heterogeneity Nonsense Frameshift Missense Insertions

29 related topics

Gene

Chromosome Genomic DNA Exons Orthologues CLCN1

18 related topics

Structure

Dimers Amino acid Membrane Α-helices Domain

7 related topics

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases: CLCN5, CLC5, CLCK2, ClC-5, DENTS, NPHL1, NPHL2, XLRH, XRN, hCIC-K2, chloride voltage-gated channel 5, DENT1
Available structures: Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2J9L, 2JA3
Band: Xp11.23 · X A1.1|X 3.21 cM
Bgee: renal medulla · secondary oocyte · corpus epididymis · human kidney · gonad
BioGPS: More reference expression data
Chr.: X chromosome (human) · X chromosome (mouse)

Topics to explore

Browse the full topic structure. Each item opens a new analysis centered on that subject.

Overview

Protein
Gene
Chloride channel
Kidney
Proximal tubules Proximal tubule
Albumin
Mutations Mutation
X-linked recessive X-linked recessive inheritance
Dent disease Dent's disease
Hypercalciuria
Nephrocalcinosis
Nephrolithiasis Kidney stone disease

Gene

Chromosome
Genomic DNA
Exons Exon
Orthologues Sequence homology
CLCN1
CLCN2
CLCN3
CLCN4
CLCN6
CLCN7
CLCNKA
CLCNKB
Gnathostomata
Gene transcripts Transcription (biology)
NH2-terminal
5' untranslated region Five prime untranslated region
Promoters Promoter (genetics)
MRNAs Messenger RNA

Structure

Dimers Protein dimer
Amino acid
Membrane Biological membrane
Α-helices Alpha helix
Domain Protein domain
Cystathionine beta-synthase Cystathionine beta synthase
Glutamic acids Glutamic acid

Localization and function

Tissues Tissue (biology)
Organellar Organelle
Brain
Muscle
Intestine Gastrointestinal tract
Collecting duct Collecting duct system
Henle's loop Loop of Henle
Receptor-mediated endocytosis
Glomerular filter. Ultrafiltration (renal)
Endosomes Endosome
V-ATPase
PH
Ligand
Receptor Receptor (biochemistry)
Lysosome
Megalin LRP2
Cubilin
Amnionless
NHE3 Sodium–hydrogen antiporter 3
Actin
Cofilin
Cytoskeleton
Cytoplasm

Clinical significance

Allelic heterogeneity
Nonsense Nonsense mutation
Frameshift Frameshift mutation
Missense Missense mutation
Insertions Insertion (genetics)
Deletions Deletion (genetics)
Splice site mutations Splice site mutation
Alu Alu element
Xenopus laevis African clawed frog
Oocytes Oocyte
Protein folding
Processing Post-translational modification
Endoplasmic reticulum
Proteasome
Knock-out mice Knockout mouse
Proteinuria
Trafficking Protein targeting
Brush border
NaPi2a Sodium-dependent phosphate transport protein 2A
Genetic testing
Healthy carrier Asymptomatic carrier
Heterozygous Zygosity
Skewed X-inactivation
Y chromosome
X chromosome
Preimplant Preimplantation genetic diagnosis
Prenatal genetic testing Prenatal testing
Genotype
Phenotype

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

Map overview Semantic statistics

Nodes95

Edges94

Triples131

Avg. degree1.98

Density0.021053

Components1

How this topic connects Entity context

See the strongest relationship patterns around the current topic before diving into the raw triples.

CLCN5

Top relations

Gene ontology · 31

CLCN5 → antiporter activity, apical part of cell, ATP binding, chloride channel activity, chloride ion binding, chloride transmembrane transport, chloride transport, cytosol, early endosome, endosome, endosome membrane, excretion, Golgi apparatus, Golgi membrane, identical protein binding, integral component of membrane, integral component of plasma membrane, ion channel activity, ion transmembrane transport, ion transport

related to Gene · 22

CLCN5 → CLCN1, CLCN2, CLCN3, CLCN4, CLCN6, CLCN7, CLCNKA, CLCNKB, DNA, Five, Gnathostomata, It, Kb, MIM, NH2-terminal, Several, The, The CLCN5, Transcript, Two

Bgee · 19

CLCN5 → cartilage tissue, corpus epididymis, cumulus cell, external carotid artery, facial motor nucleus, gonad, human kidney, internal carotid artery, jejunal mucosa, liver, mandibular prominence, migratory enteric neural crest cell, primitive streak, renal medulla, retinal pigment epithelium, secondary oocyte, testicle, yolk sac, zygote

RNA expression pattern · 19

related to Clinical significance · 8

CLCN5 → Alu, Dent, Functional, MIM, The, To, UTR, Xenopus

related to External links · 8

CLCN5 → Human CLCN5, Medicine, Medicine Medical Subject Headings, MeSH, National Library, This, UCSC Genome Browser, United States National Library

Band · 2

CLCN5 → X A1.1|X 3.21 cM, Xp11.23

Chr. · 2

CLCN5 → X chromosome (human), X chromosome (mouse)

End · 2

CLCN5 → 50,099,235 bp, 7,185,597 bp

Aliases · 1

CLCN5 → CLCN5, CLC5, CLCK2, ClC-5, DENTS, NPHL1, NPHL2, XLRH, XRN, hCIC-K2, chloride voltage-gated channel 5, DENT1

Important terminology Word statistics

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

clc-5 gene disease protein human dent bp kidney proximal tubular chromosome two channel low-molecular-weight chr mutations band cells chloride membrane

Entity relationships Subject–Predicate–Object triples

Subject	Predicate	Object	Confidence	Src
CLCN5	Aliases	CLCN5, CLC5, CLCK2, ClC-5, DENTS, NPHL1, NPHL2, XLRH, XRN, hCIC-K2, chloride voltage-gated channel 5, DENT1	1.00	infobox
CLCN5	Available structures	Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2J9L, 2JA3	1.00	infobox
CLCN5	Band	Xp11.23	1.00	infobox
CLCN5	Band	X A1.1\|X 3.21 cM	1.00	infobox
CLCN5	Bgee	renal medulla	1.00	infobox
CLCN5	Bgee	secondary oocyte	1.00	infobox
CLCN5	Bgee	corpus epididymis	1.00	infobox
CLCN5	Bgee	human kidney	1.00	infobox
CLCN5	Bgee	gonad	1.00	infobox
CLCN5	Bgee	cartilage tissue	1.00	infobox
CLCN5	Bgee	retinal pigment epithelium	1.00	infobox
CLCN5	Bgee	jejunal mucosa	1.00	infobox
CLCN5	Bgee	liver	1.00	infobox
CLCN5	Bgee	testicle	1.00	infobox
CLCN5	Bgee	internal carotid artery	1.00	infobox
CLCN5	Bgee	facial motor nucleus	1.00	infobox
CLCN5	Bgee	migratory enteric neural crest cell	1.00	infobox
CLCN5	Bgee	external carotid artery	1.00	infobox
CLCN5	Bgee	zygote	1.00	infobox
CLCN5	Bgee	yolk sac	1.00	infobox
CLCN5	Bgee	cumulus cell	1.00	infobox
CLCN5	Bgee	primitive streak	1.00	infobox
CLCN5	Bgee	mandibular prominence	1.00	infobox
CLCN5	BioGPS	More reference expression data	1.00	infobox
CLCN5	Chr.	X chromosome (human)	1.00	infobox
CLCN5	Chr.	X chromosome (mouse)	1.00	infobox
CLCN5	Databases	NCBI: entry; OMA: entry	1.00	infobox
CLCN5	End	50,099,235 bp	1.00	infobox
CLCN5	End	7,185,597 bp	1.00	infobox
CLCN5	Ensembl	ENSG00000171365	1.00	infobox

Related concept clusters Concept neighborhoods

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Connections between topic areas Semantic bridges

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