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The CLCN family of voltage-dependent chloride channel genes comprises nine members (CLCN1-7, Ka and Kb) which demonstrate quite diverse functional characteristics while sharing significant sequence homology. The protein encoded by this gene regulates the electric excitability of the skeletal muscle membrane. Mutations in this gene cause two forms of…
The analysis highlights Overview, Related Topics and Entities as prominent areas in the source structure around CLCN1.
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
High-confidence facts extracted from structured source data. Use them as anchors for further research.
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The extracted context around CLCN1 shows recurring relationship patterns in the source. For example, CLCN1 → ankle, biceps brachii, body of tongue, buccal mucosa cell, extensor digitorum longus muscle, extraocular muscle, gastrocnemius muscle, gonad, muscle of thigh, plantaris muscle, quadriceps femoris muscle, skeletal muscle tissue, Skeletal muscle tissue of biceps brachii, Skeletal muscle tissue of rectus abdominis, soleus muscle, tibialis anterior muscle, triceps brachii muscle, triceps surae, vastus lateralis muscle Another extracted example is CLCN1 → chloride channel activity, chloride channel complex, chloride transmembrane transport, chloride transport, integral component of membrane, integral component of plasma membrane, ion transmembrane transport, ion transport, membrane, muscle contraction, neuronal action potential propagation, plasma membrane, protein binding, protein homodimerization activity, regulation of ion transmembrane transport, sarcolemma, transmembrane transport, voltage-gated chloride channel activity, voltage-gated ion channel activity. Use these groups to spot repeated connection types before inspecting the individual relationships.
Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.
chloride channel muscle gene human skeletal protein ions myotonia bp chr band chromosome cells location function ion encoded mutations cause
TTTA extracted 77 structured relationships around CLCN1. Examples in this analysis include CLCN1 → Aliases → CLCN1, CLC1, chloride voltage-gated channel 1 and CLCN1 → Band → 7q34. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| CLCN1 | Aliases | CLCN1, CLC1, chloride voltage-gated channel 1 | 1.00 | infobox |
| CLCN1 | Band | 7q34 | 1.00 | infobox |
| CLCN1 | Band | 6 B2.1|6 20.57 cM | 1.00 | infobox |
| CLCN1 | Bgee | muscle of thigh | 1.00 | infobox |
| CLCN1 | Bgee | triceps brachii muscle | 1.00 | infobox |
| CLCN1 | Bgee | Skeletal muscle tissue of rectus abdominis | 1.00 | infobox |
| CLCN1 | Bgee | vastus lateralis muscle | 1.00 | infobox |
| CLCN1 | Bgee | biceps brachii | 1.00 | infobox |
| CLCN1 | Bgee | gastrocnemius muscle | 1.00 | infobox |
| CLCN1 | Bgee | Skeletal muscle tissue of biceps brachii | 1.00 | infobox |
| CLCN1 | Bgee | buccal mucosa cell | 1.00 | infobox |
| CLCN1 | Bgee | gonad | 1.00 | infobox |
| CLCN1 | Bgee | body of tongue | 1.00 | infobox |
| CLCN1 | Bgee | extensor digitorum longus muscle | 1.00 | infobox |
| CLCN1 | Bgee | plantaris muscle | 1.00 | infobox |
| CLCN1 | Bgee | skeletal muscle tissue | 1.00 | infobox |
| CLCN1 | Bgee | extraocular muscle | 1.00 | infobox |
| CLCN1 | Bgee | quadriceps femoris muscle | 1.00 | infobox |
| CLCN1 | Bgee | ankle | 1.00 | infobox |
| CLCN1 | Bgee | triceps surae | 1.00 | infobox |
| CLCN1 | Bgee | soleus muscle | 1.00 | infobox |
| CLCN1 | Bgee | tibialis anterior muscle | 1.00 | infobox |
| CLCN1 | BioGPS | More reference expression data | 1.00 | infobox |
| CLCN1 | Chr. | Chromosome 7 (human) | 1.00 | infobox |
| CLCN1 | Chr. | Chromosome 6 (mouse) | 1.00 | infobox |
| CLCN1 | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| CLCN1 | End | 143,352,083 bp | 1.00 | infobox |
| CLCN1 | End | 42,292,690 bp | 1.00 | infobox |
| CLCN1 | Ensembl | ENSG00000188037 | 1.00 | infobox |
| CLCN1 | Entrez | 1180 | 1.00 | infobox |
The concept neighborhoods around CLCN1 bring nearby vocabulary together. In this analysis, examples include Ion, Gene and Location. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
Bridges highlight paths between different parts of the CLCN1 map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around CLCN1 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Overview, Related Topics & Entities, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — CLCN1 · EN edition · Analysis: TopicsToTalkAbout