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CLCN1: Overview, Related Topics & Entities

The CLCN family of voltage-dependent chloride channel genes comprises nine members (CLCN1-7, Ka and Kb) which demonstrate quite diverse functional characteristics while sharing significant sequence homology. The protein encoded by this gene regulates the electric excitability of the skeletal muscle membrane. Mutations in this gene cause two forms of…

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CLCN1 topic overview

The analysis highlights Overview, Related Topics and Entities as prominent areas in the source structure around CLCN1.

Related topics
6
Source areas
1
Connected nodes
7
Extracted relationships
77
Related term clusters
7
Bridge connections
7

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 6 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
CLCN1, CLC1, chloride voltage-gated channel 1
Band
7q34 · 6 B2.1|6 20.57 cM
Bgee
muscle of thigh · triceps brachii muscle · Skeletal muscle tissue of rectus abdominis · vastus lateralis muscle · biceps brachii
BioGPS
More reference expression data
Chr.
Chromosome 7 (human) · Chromosome 6 (mouse)
Databases
NCBI: entry; OMA: entry

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CLCN1

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

For the semantics nerds

You can skip this section if you’re here for content ideas and keyword inspiration.

Advanced semantic analysis

How CLCN1 connects Entity context

The extracted context around CLCN1 shows recurring relationship patterns in the source. For example, CLCN1 → ankle, biceps brachii, body of tongue, buccal mucosa cell, extensor digitorum longus muscle, extraocular muscle, gastrocnemius muscle, gonad, muscle of thigh, plantaris muscle, quadriceps femoris muscle, skeletal muscle tissue, Skeletal muscle tissue of biceps brachii, Skeletal muscle tissue of rectus abdominis, soleus muscle, tibialis anterior muscle, triceps brachii muscle, triceps surae, vastus lateralis muscle Another extracted example is CLCN1 → chloride channel activity, chloride channel complex, chloride transmembrane transport, chloride transport, integral component of membrane, integral component of plasma membrane, ion transmembrane transport, ion transport, membrane, muscle contraction, neuronal action potential propagation, plasma membrane, protein binding, protein homodimerization activity, regulation of ion transmembrane transport, sarcolemma, transmembrane transport, voltage-gated chloride channel activity, voltage-gated ion channel activity. Use these groups to spot repeated connection types before inspecting the individual relationships.

CLCN1

Top relations

Bgee · 19
CLCN1 → ankle, biceps brachii, body of tongue, buccal mucosa cell, extensor digitorum longus muscle, extraocular muscle, gastrocnemius muscle, gonad, muscle of thigh, plantaris muscle, quadriceps femoris muscle, skeletal muscle tissue, Skeletal muscle tissue of biceps brachii, Skeletal muscle tissue of rectus abdominis, soleus muscle, tibialis anterior muscle, triceps brachii muscle, triceps surae, vastus lateralis muscle
Gene ontology · 19
CLCN1 → chloride channel activity, chloride channel complex, chloride transmembrane transport, chloride transport, integral component of membrane, integral component of plasma membrane, ion transmembrane transport, ion transport, membrane, muscle contraction, neuronal action potential propagation, plasma membrane, protein binding, protein homodimerization activity, regulation of ion transmembrane transport, sarcolemma, transmembrane transport, voltage-gated chloride channel activity, voltage-gated ion channel activity
RNA expression pattern · 19
CLCN1 → ankle, biceps brachii, body of tongue, buccal mucosa cell, extensor digitorum longus muscle, extraocular muscle, gastrocnemius muscle, gonad, muscle of thigh, plantaris muscle, quadriceps femoris muscle, skeletal muscle tissue, Skeletal muscle tissue of biceps brachii, Skeletal muscle tissue of rectus abdominis, soleus muscle, tibialis anterior muscle, triceps brachii muscle, triceps surae, vastus lateralis muscle
Band · 2
CLCN1 → 6 B2.1|6 20.57 cM, 7q34
Chr. · 2
CLCN1 → Chromosome 6 (mouse), Chromosome 7 (human)
End · 2
CLCN1 → 143,352,083 bp, 42,292,690 bp
Aliases · 1
CLCN1 → CLCN1, CLC1, chloride voltage-gated channel 1
BioGPS · 1
CLCN1 → More reference expression data
Databases · 1
CLCN1 → NCBI: entry; OMA: entry
Ensembl · 1
CLCN1 → ENSG00000188037

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

chloride channel muscle gene human skeletal protein ions myotonia bp chr band chromosome cells location function ion encoded mutations cause

CLCN1 relationships Subject–Predicate–Object triples

TTTA extracted 77 structured relationships around CLCN1. Examples in this analysis include CLCN1 → Aliases → CLCN1, CLC1, chloride voltage-gated channel 1 and CLCN1 → Band → 7q34. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
CLCN1AliasesCLCN1, CLC1, chloride voltage-gated channel 11.00infobox
CLCN1Band7q341.00infobox
CLCN1Band6 B2.1|6 20.57 cM1.00infobox
CLCN1Bgeemuscle of thigh1.00infobox
CLCN1Bgeetriceps brachii muscle1.00infobox
CLCN1BgeeSkeletal muscle tissue of rectus abdominis1.00infobox
CLCN1Bgeevastus lateralis muscle1.00infobox
CLCN1Bgeebiceps brachii1.00infobox
CLCN1Bgeegastrocnemius muscle1.00infobox
CLCN1BgeeSkeletal muscle tissue of biceps brachii1.00infobox
CLCN1Bgeebuccal mucosa cell1.00infobox
CLCN1Bgeegonad1.00infobox
CLCN1Bgeebody of tongue1.00infobox
CLCN1Bgeeextensor digitorum longus muscle1.00infobox
CLCN1Bgeeplantaris muscle1.00infobox
CLCN1Bgeeskeletal muscle tissue1.00infobox
CLCN1Bgeeextraocular muscle1.00infobox
CLCN1Bgeequadriceps femoris muscle1.00infobox
CLCN1Bgeeankle1.00infobox
CLCN1Bgeetriceps surae1.00infobox
CLCN1Bgeesoleus muscle1.00infobox
CLCN1Bgeetibialis anterior muscle1.00infobox
CLCN1BioGPSMore reference expression data1.00infobox
CLCN1Chr.Chromosome 7 (human)1.00infobox
CLCN1Chr.Chromosome 6 (mouse)1.00infobox
CLCN1DatabasesNCBI: entry; OMA: entry1.00infobox
CLCN1End143,352,083 bp1.00infobox
CLCN1End42,292,690 bp1.00infobox
CLCN1EnsemblENSG000001880371.00infobox
CLCN1Entrez11801.00infobox

Related concept clusters Related term clusters

The concept neighborhoods around CLCN1 bring nearby vocabulary together. In this analysis, examples include Ion, Gene and Location. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • CLCN1
    • Ion
    • Gene
    • Location
    • Skeletal
    • Human
    • Cell
    • Voltage-gated
    • Muscle
    • Cells
    • Function
    • Chromosome
    • Ions
  • clcn1
    • Ion
    • Gene
    • Location
    • Skeletal
    • Human
    • Cell
    • Voltage-gated
    • Muscle
    • Cells
    • Function
    • Chromosome
    • Ions
  • protein
    • Membrane
    • Skeletal
    • Muscle
    • Myotonia
    • Chloride
    • Clcn1
    • Body
    • Cause
    • Cell
    • Congenita
    • Congenital
    • Contraction
  • gene
    • Human
    • Location
    • Clcn1
    • Muscle
    • Chromosome
    • Protein
    • Bp
    • Chr
    • Skeletal
    • Congenita
    • End
    • Membrane
  • ion channel
    • Chloride
    • Cell
    • Clcn1
    • Ion
    • Ions
    • Myotonia
    • Voltage-gated
    • Gene
    • End
    • Function
    • Membrane
    • Mouse
  • congenital myotonia
    • Cell
    • Congenital
    • Myotonia
    • Thomsen
    • Chloride
    • Ion
    • Mutations
    • Ions
    • Protein
    • Clcn1
    • Body
    • Contraction
  • ions
    • Ion
    • Myotonia
    • Muscle
    • Cell

Connections between topic areas Semantic bridges

Bridges highlight paths between different parts of the CLCN1 map and can reveal research angles that are easy to miss in a flat list.

Min side: 3

Map overview Semantic statistics

CLCN1

Nodes8
Edges7
Triples77
Avg. degree1.75
Density0.25
Components1

Source & methodology

TTTA analyzes the structure around CLCN1 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Overview, Related Topics & Entities, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — CLCN1 · EN edition · Analysis: TopicsToTalkAbout

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