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C3b

C3b is the larger of two elements formed by the cleavage of complement component 3, and is considered an important part of the innate immune system. C3b is potent in opsonization: tagging pathogens, immune complexes (antigen-antibody), and apoptotic cells for phagocytosis. Additionally, C3b plays a role in forming a C3 convertase when bound to Factor B…

Art, C3 convertase & Clinical significance

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Overview

C3 convertase

Opsonization and pathogen clearance

Clinical significance

Advanced semantic analysis

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Map overview Semantic statistics

C3b

Nodes43
Edges42
Triples76
Avg. degree1.95
Density0.046512
Components1

How this topic connects Entity context

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C3b

Top relations

related to Classical pathway · 20
C3b → Binding, C1, C2, C3, C3a, C4, C4b2b3b, C4bC2b, C5, C5a, C5b, C6, C7, C8, C9, IgG, IgM, In, The C1, This
related to Regulation · 13
C3b → An, C1q, C3, C3bBb, CD46, Furthermore, Given, MCP, One, RCA, RCAs, The, This
related to Alternative pathway · 11
C3b → C3, C3a, C3Bb3b C5, C3bBb C3, Factor, Factor Bb, If, In, Incorporation, It, This C3bBb
related to Opsonization and pathogen clearance · 9
C3b → Additionally, C3, C3b-tagged, C5, Cr1, Fc, Furthermore, In, Once
related to Clinical significance · 8
C3b → AIDS, C3, Cr1, Due, For, Healthy, However, Patients
see also · 2
C3b → C3, C3a
is a · 1
C3b → larger of two elements formed by the cleavage of complement component 3

Important terminology Word statistics

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Important terminology

c3 convertase surface cells immune formation complement complex covalently cleavage pathway pathogen bind microbial system signal alternative phagocytosis neutrophils host

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
C3bis alarger of two elements formed by the cleavage of complement component 30.90text
systemic lupus erythematosusinstance ofin which deposits of C3 in the glomeruli disrupt kidney function and can eventually result in kidney failure.Patients with diseases associated with elevated levels of immune com…0.80text
leprosyinstance ofin which deposits of C3 in the glomeruli disrupt kidney function and can eventually result in kidney failure.Patients with diseases associated with elevated levels of immune com…0.80text
and AIDS are found to have significantly decreased levels of the C3b receptorinstance ofin which deposits of C3 in the glomeruli disrupt kidney function and can eventually result in kidney failure.Patients with diseases associated with elevated levels of immune com…0.80text
Cr1instance ofin which deposits of C3 in the glomeruli disrupt kidney function and can eventually result in kidney failure.Patients with diseases associated with elevated levels of immune com…0.80text
expression on erythrocytesinstance ofin which deposits of C3 in the glomeruli disrupt kidney function and can eventually result in kidney failure.Patients with diseases associated with elevated levels of immune com…0.80text
as well as altered expression of Cr1 on neutrophils in response to stimulationinstance ofin which deposits of C3 in the glomeruli disrupt kidney function and can eventually result in kidney failure.Patients with diseases associated with elevated levels of immune com…0.80text
AIDS do not display this response to stimulationinstance ofpatients with diseases0.80text
which results in reduced phagocytosis by the neutrophilsinstance ofpatients with diseases0.80text
likely plays a critical role in disease progression.The absence of regulatory proteinsinstance ofpatients with diseases0.80text
resulting in excessive C3 activationinstance ofpatients with diseases0.80text
C3b formationinstance ofpatients with diseases0.80text

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