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Complement receptor 1: Regions, Gene structure and isoforms & Role in blood groups

Complement receptor type 1 (CR1) also known as C3b/C4b receptor or CD35 (cluster of differentiation 35) is a protein that in humans is encoded by the CR1 gene.

Language: English [EN]
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Complement receptor 1 topic overview

The analysis highlights Regions, Gene structure and isoforms and Role in blood groups as prominent areas in the source structure around Complement receptor 1.

Related topics
78
Source areas
8
Connected nodes
86
Extracted relationships
83
Concept neighborhoods
31
Bridge connections
86

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 23 topics
Gene structure and isoforms · 17 topics
Role in blood groups · 15 topics
Rosetting · 8 topics
Alleles · 5 topics
Gene region · 4 topics
Structure · 4 topics
Clinical diagnostic · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
CR1, C3BR, C4BR, CD35, KN, complement component 3b/4b receptor 1 (Knops blood group), complement C3b/C4b receptor 1 (Knops blood group)
Available structures
Available structuresPDBHuman UniProt search: PDBe RCSB List of PDB id codes1GKG, 1GKN, 1PPQ, 2Q7Z, 2MCY, 2MCZ, 5FO9
Band
1q32.2
Bgee
blood · monocyte · spleen · appendix · lymph node
BioGPS
More reference expression data
Chr.
Chromosome 1 (human)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Gene region

Gene structure and isoforms

Structure

Alleles

Rosetting

Role in blood groups

Clinical diagnostic

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Complement receptor 1 connects Entity context

The extracted context around Complement receptor 1 shows recurring relationship patterns in the source. For example, Complement receptor 1 → cell surface, complement activation, classical pathway, complement component C3b binding, complement component C3b receptor activity, complement component C4b binding, complement component C4b receptor activity, complement receptor mediated signaling pathway, extracellular exosome, ficolin-1-rich granule membrane, immune system process, innate immune response, integral component of membrane, integral component of plasma membrane, membrane, negative regulation of complement activation, alternative pathway, negative regulation of complement activation, classical pathway, negative regulation of serine-type endopeptidase activity, neutrophil degranulation, plasma membrane, positive regulation of serine-type endopeptidase activity Another extracted example is Complement receptor 1 → African, C3b, C4b, CR1, CR1-like, Curiously, European, Four, GPI, Homozygotes, LHR-A, LHR-B, LHR-C, Multiple, The, These, Two. Use these groups to spot repeated connection types before inspecting the individual relationships.

Complement receptor 1

Top relations

Gene ontology · 26
Complement receptor 1 → cell surface, complement activation, classical pathway, complement component C3b binding, complement component C3b receptor activity, complement component C4b binding, complement component C4b receptor activity, complement receptor mediated signaling pathway, extracellular exosome, ficolin-1-rich granule membrane, immune system process, innate immune response, integral component of membrane, integral component of plasma membrane, membrane, negative regulation of complement activation, alternative pathway, negative regulation of complement activation, classical pathway, negative regulation of serine-type endopeptidase activity, neutrophil degranulation, plasma membrane, positive regulation of serine-type endopeptidase activity
related to Alleles · 17
Complement receptor 1 → African, C3b, C4b, CR1, CR1-like, Curiously, European, Four, GPI, Homozygotes, LHR-A, LHR-B, LHR-C, Multiple, The, These, Two
Bgee · 10
Complement receptor 1 → appendix, blood, bone marrow, bone marrow cell, granulocyte, lymph node, monocyte, spleen, superficial temporal artery, trabecular bone
RNA expression pattern · 10
Complement receptor 1 → appendix, blood, bone marrow, bone marrow cell, granulocyte, lymph node, monocyte, spleen, superficial temporal artery, trabecular bone
Aliases · 1
Complement receptor 1 → CR1, C3BR, C4BR, CD35, KN, complement component 3b/4b receptor 1 (Knops blood group), complement C3b/C4b receptor 1 (Knops blood group)
Available structures · 1
Complement receptor 1 → Available structuresPDBHuman UniProt search: PDBe RCSB List of PDB id codes1GKG, 1GKN, 1PPQ, 2Q7Z, 2MCY, 2MCZ, 5FO9
Band · 1
Complement receptor 1 → 1q32.2
BioGPS · 1
Complement receptor 1 → More reference expression data
Chr. · 1
Complement receptor 1 → Chromosome 1 (human)
Databases · 1
Complement receptor 1 → NCBI: entry; OMA: entry

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

gene cr1 protein complement receptor erythrocytes blood human also alleles cr2 immune region system c3b c4b complexes exons membrane knops

Complement receptor 1 relationships Subject–Predicate–Object triples

TTTA extracted 83 structured relationships around Complement receptor 1. Examples in this analysis include Complement receptor 1 → Aliases → CR1, C3BR, C4BR, CD35, KN, complement component 3b/4b receptor 1 (Knops blood group), complement C3b/C4b receptor 1 (Knops blood group) and Complement receptor 1 → Available structures → Available structuresPDBHuman UniProt search: PDBe RCSB List of PDB id codes1GKG, 1GKN, 1PPQ, 2Q7Z, 2MCY, 2MCZ, 5FO9. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Complement receptor 1AliasesCR1, C3BR, C4BR, CD35, KN, complement component 3b/4b receptor 1 (Knops blood group), complement C3b/C4b receptor 1 (Knops blood group)1.00infobox
Complement receptor 1Available structuresAvailable structuresPDBHuman UniProt search: PDBe RCSB List of PDB id codes1GKG, 1GKN, 1PPQ, 2Q7Z, 2MCY, 2MCZ, 5FO91.00infobox
Complement receptor 1Band1q32.21.00infobox
Complement receptor 1Bgeeblood1.00infobox
Complement receptor 1Bgeemonocyte1.00infobox
Complement receptor 1Bgeespleen1.00infobox
Complement receptor 1Bgeeappendix1.00infobox
Complement receptor 1Bgeelymph node1.00infobox
Complement receptor 1Bgeebone marrow1.00infobox
Complement receptor 1Bgeetrabecular bone1.00infobox
Complement receptor 1Bgeegranulocyte1.00infobox
Complement receptor 1Bgeesuperficial temporal artery1.00infobox
Complement receptor 1Bgeebone marrow cell1.00infobox
Complement receptor 1BioGPSMore reference expression data1.00infobox
Complement receptor 1Chr.Chromosome 1 (human)1.00infobox
Complement receptor 1DatabasesNCBI: entry; OMA: entry1.00infobox
Complement receptor 1End207,641,765 bp1.00infobox
Complement receptor 1EnsemblENSG000002037101.00infobox
Complement receptor 1Entrez13781.00infobox
Complement receptor 1External IDsOMIM: 120620; GeneCards: CR11.00infobox
Complement receptor 1Gene location (Human)Gene location (Human)Chr.Chromosome 1 (human)Band1q32.2Start207,496,147 bpEnd207,641,765 bp1.00infobox
Complement receptor 1Gene ontologyvirus receptor activity1.00infobox
Complement receptor 1Gene ontologycomplement component C3b receptor activity1.00infobox
Complement receptor 1Gene ontologycomplement component C4b receptor activity1.00infobox
Complement receptor 1Gene ontologycomplement component C3b binding1.00infobox
Complement receptor 1Gene ontologycomplement component C4b binding1.00infobox
Complement receptor 1Gene ontologyintegral component of membrane1.00infobox
Complement receptor 1Gene ontologymembrane1.00infobox
Complement receptor 1Gene ontologyplasma membrane1.00infobox
Complement receptor 1Gene ontologyintegral component of plasma membrane1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Complement receptor 1 bring nearby vocabulary together. In this analysis, examples include Receptor, Cr1 and Gene. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Complement receptor 1
    • Receptor
    • Cr1
    • Gene
    • C3b
    • C4b
    • Immune
    • Protein
    • Chromosome
    • Primates
    • Type
    • Activation
    • Cell
  • complement receptor 1
    • Receptor
    • Cr1
    • Type
    • Gene
    • C3b
    • C4b
    • Cell
    • Membrane
    • Immune
    • Protein
    • Cr2
    • Bp
  • protein
    • Amino
    • Membrane
    • System
    • Human
    • Receptor
    • Gene
    • Blood
    • Expression
    • Type
    • Activation
    • Antigen
    • Cell
  • gene
    • Receptor
    • Cr2
    • Human
    • Protein
    • Associated
    • Chromosome
    • Expression
    • Primates
    • Activation
    • Knops
    • Membrane
    • Alleles
  • regulators of complement activation
    • Receptor
    • Cr1
    • Chromosome
    • Gene
    • C3b
    • C4b
    • Cell
    • Cells
    • Membrane
    • System
    • Immune
    • Protein
  • complement
    • Receptor
    • Cr1
    • Gene
    • C3b
    • C4b
    • Immune
    • Protein
    • Chromosome
    • Primates
    • Type
    • Activation
    • Cell
  • membrane cofactor protein
    • Cell
    • Expression
    • Type
    • Receptor
    • Antigen
    • Amino
    • Membrane
    • Protein
    • System
    • Human
    • Gene
    • Blood
  • complement receptor 2
    • Receptor
    • Cr1
    • Type
    • Gene
    • C3b
    • C4b
    • Cell
    • Membrane
    • Immune
    • Protein
    • Cr2
    • Bp

Connections between topic areas Semantic bridges

For Complement receptor 1, one of the stronger structural bridges in this analysis connects Complement receptor 1 with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Complement receptor 1Overview · splits 63 ⟂ 24
Complement receptor 1Gene structure and isoforms · splits 69 ⟂ 18
Complement receptor 1Role in blood groups · splits 71 ⟂ 16
Complement receptor 1Rosetting · splits 78 ⟂ 9
Complement receptor 1Alleles · splits 81 ⟂ 6
Complement receptor 1Gene region · splits 82 ⟂ 5
Complement receptor 1Structure · splits 82 ⟂ 5
Complement receptor 1Clinical diagnostic · splits 84 ⟂ 3

Map overview Semantic statistics

Complement receptor 1

Nodes87
Edges86
Triples83
Avg. degree1.98
Density0.022989
Components1

Source & methodology

TTTA analyzes the structure around Complement receptor 1 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Regions, Gene structure and isoforms & Role in blood groups, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Complement receptor 1 · EN edition · Analysis: TopicsToTalkAbout

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