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Factor D: Function, Role in diseases & Structure

Factor D (EC 3.4.21.46, C3 proactivator convertase, properdin factor D esterase, factor D (complement), complement factor D, CFD, adipsin) is a protein which in humans is encoded by the CFD gene. Factor D is involved in the alternative complement pathway of the complement system where it cleaves factor B.

Language: English [EN]
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Factor D topic overview

The analysis highlights Function, Role in diseases and Structure as prominent areas in the source structure around Factor D.

Related topics
21
Source areas
6
Connected nodes
27
Extracted relationships
62
Concept neighborhoods
11
Bridge connections
27

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 6 topics
Function · 4 topics
Role in diseases · 4 topics
Mechanism of action · 3 topics
Structure · 3 topics
Regulation · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Alt. symbols
DF, PFD
Domains
InterPro
HGNC
2771
Locus
Chr. 19 p13.3
NCBI gene
1675
OMIM
134350

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Structure

Mechanism of action

Regulation

Role in diseases

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Factor D connects Entity context

The extracted context around Factor D shows recurring relationship patterns in the source. For example, Factor D → Arg234, Arg234-Lys235, Asp102, Asp189, Asp189-Arg218, Ba, Bb, Before, C3-convertase, C3b, C3bB, C3bBb, Cleavage, Factor, His57, In, It, Other, Ser195, The Another extracted example is Factor D → ACH-4471, Deficiency, Diseases, Factor, In, Neisseria, Patients, Phase, PNH, Ser42, Small, TAG, The. Use these groups to spot repeated connection types before inspecting the individual relationships.

Factor D

Top relations

related to Mechanism of action · 21
Factor D → Arg234, Arg234-Lys235, Asp102, Asp189, Asp189-Arg218, Ba, Bb, Before, C3-convertase, C3b, C3bB, C3bBb, Cleavage, Factor, His57, In, It, Other, Ser195, The
related to Role in diseases · 13
Factor D → ACH-4471, Deficiency, Diseases, Factor, In, Neisseria, Patients, Phase, PNH, Ser42, Small, TAG, The
related to Regulation · 5
Factor D → Factor, However, In, MASP-3, The
related to Structure · 5
Factor D → All, Factor, In, The, These
related to Clinical significance · 3
Factor D → Factor, The, This
related to Function · 3
Factor D → Factor, Finally, The
Alt. symbols · 1
Factor D → DF, PFD
Domains · 1
Factor D → InterPro
HGNC · 1
Factor D → 2771
Locus · 1
Factor D → Chr. 19 p13.3

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

factor complement protein serine form gene encoded alternative pathway family known high patients may catalytic inhibitors deficiency infections 19 role

Factor D relationships Subject–Predicate–Object triples

TTTA extracted 62 structured relationships around Factor D. Examples in this analysis include Factor D → Alt. symbols → DF, PFD and Factor D → Domains → InterPro. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Factor DAlt. symbolsDF, PFD1.00infobox
Factor DDomainsInterPro1.00infobox
Factor DHGNC27711.00infobox
Factor DLocusChr. 19 p13.31.00infobox
Factor DNCBI gene16751.00infobox
Factor DOMIM1343501.00infobox
Factor DRefSeqNM_0019281.00infobox
Factor DSearch forSearch forStructuresSwiss-modelDomainsInterPro1.00infobox
Factor DStructuresSwiss-model1.00infobox
Factor DSymbolCFD1.00infobox
Factor DUniProtP007461.00infobox
Factor Dis aserine protease that stimulates glucose transport for triglyceride accumulation in fats cells and inhibits lipolysis0.90text

Related concept clusters Concept neighborhoods

The concept neighborhoods around Factor D bring nearby vocabulary together. In this analysis, examples include Form, Catalytic and Deficiency. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Factor D
    • Form
    • Catalytic
    • Deficiency
    • Infections
    • Inhibitors
    • Patients
    • Serine
    • Active
    • Bond
    • Bridge
    • C3bb
    • Cleavage
  • factor d
    • Form
    • Catalytic
    • Deficiency
    • Infections
    • Inhibitors
    • Patients
    • Serine
    • Active
    • Bond
    • Bridge
    • C3bb
    • Cleavage
  • factor b
    • Form
    • Catalytic
    • Deficiency
    • Infections
    • Inhibitors
    • Patients
    • Serine
    • Active
    • Bond
    • Bridge
    • C3bb
    • Cleavage
  • factor d deficiency
    • Infections
    • Reoccurring
    • May
    • Form
    • Gene
    • Inhibitors
    • Patients
    • Catalytic
    • Deficiency
    • Factor
    • Serine
    • Active
  • alternative complement pathway
    • Pathway
    • Alternative
    • Complement
    • Encoded
    • Protein
    • Bond
    • Cfd
    • Cleavage
    • Role
    • Scissile
    • Known
    • Gene
  • serine proteases
    • Proteases
    • Serine
    • Family
    • Gene
    • Major
    • Protein
    • Active
    • Cause
    • Conformation
    • Self-inhibited
    • Deficiency
    • Encoded
  • complement system
    • Alternative
    • Encoded
    • Pathway
    • Protein
    • Cfd
    • Role
    • Gene
    • Inhibitors
    • Known
    • May
    • Factor
  • scissile bond
    • Cleavage
    • Scissile
    • C3bb
    • Complex
    • Results
    • Substrate
    • Known
    • Pathway
    • Form
    • Factor

Connections between topic areas Semantic bridges

For Factor D, one of the stronger structural bridges in this analysis connects Factor D with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Factor D — Overview · splits 21 ⟂ 7
Factor D — Function · splits 23 ⟂ 5
Factor D — Role in diseases · splits 23 ⟂ 5
Factor D — Structure · splits 24 ⟂ 4
Factor D — Mechanism of action · splits 24 ⟂ 4

Map overview Semantic statistics

Factor D

Nodes28
Edges27
Triples62
Avg. degree1.93
Density0.071429
Components1

Source & methodology

TTTA analyzes the structure around Factor D to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Function, Role in diseases & Structure, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Factor D · EN edition · Analysis: TopicsToTalkAbout

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