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Factor D

Factor D (EC 3.4.21.46, C3 proactivator convertase, properdin factor D esterase, factor D (complement), complement factor D, CFD, adipsin) is a protein which in humans is encoded by the CFD gene. Factor D is involved in the alternative complement pathway of the complement system where it cleaves factor B.

Function, Role in diseases & Structure

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Explore the main themes, entities and connections around Factor D. Start with the topic map, then use the sections below for research and deeper semantic analysis.

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Function

TrypsinSerine proteasesAdipocytesLipolysis
4 related topics

Role in diseases

Factor D deficiencyNeisseriaParoxysmal nocturnal hemoglobinuriaEculizumab
4 related topics

Structure

ChymotrypsinΒ-barrelLoops
3 related topics

Mechanism of action

Scissile bondC3bC3-convertase
3 related topics

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Alt. symbols
DF, PFD
Domains
InterPro
HGNC
2771
Locus
Chr. 19 p13.3
NCBI gene
1675
OMIM
134350

Topics to explore

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Overview

Function

Structure

Mechanism of action

Regulation

Role in diseases

Advanced semantic analysis

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Map overview Semantic statistics

Factor D

Nodes28
Edges27
Triples62
Avg. degree1.93
Density0.071429
Components1

How this topic connects Entity context

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Factor D

Top relations

related to Mechanism of action · 21
Factor D → Arg234, Arg234-Lys235, Asp102, Asp189, Asp189-Arg218, Ba, Bb, Before, C3-convertase, C3b, C3bB, C3bBb, Cleavage, Factor, His57, In, It, Other, Ser195, The
related to Role in diseases · 13
Factor D → ACH-4471, Deficiency, Diseases, Factor, In, Neisseria, Patients, Phase, PNH, Ser42, Small, TAG, The
related to Regulation · 5
Factor D → Factor, However, In, MASP-3, The
related to Structure · 5
Factor D → All, Factor, In, The, These
related to Clinical significance · 3
Factor D → Factor, The, This
related to Function · 3
Factor D → Factor, Finally, The
Alt. symbols · 1
Factor D → DF, PFD
Domains · 1
Factor D → InterPro
HGNC · 1
Factor D → 2771
Locus · 1
Factor D → Chr. 19 p13.3

Important terminology Word statistics

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Important terminology

factor complement protein serine form gene encoded alternative pathway family known high patients may catalytic inhibitors deficiency infections 19 role

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Factor DAlt. symbolsDF, PFD1.00infobox
Factor DDomainsInterPro1.00infobox
Factor DHGNC27711.00infobox
Factor DLocusChr. 19 p13.31.00infobox
Factor DNCBI gene16751.00infobox
Factor DOMIM1343501.00infobox
Factor DRefSeqNM_0019281.00infobox
Factor DSearch forSearch forStructuresSwiss-modelDomainsInterPro1.00infobox
Factor DStructuresSwiss-model1.00infobox
Factor DSymbolCFD1.00infobox
Factor DUniProtP007461.00infobox
Factor Dis aserine protease that stimulates glucose transport for triglyceride accumulation in fats cells and inhibits lipolysis0.90text

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