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Complement component 2: Art, Function & Overview

Complement C2 is a protein that in humans is encoded by the C2 gene. The protein encoded by this gene is part of the classical pathway of the complement system, acting as a multi-domain serine protease, which are a class of enzymes that cleave peptide bonds in other proteins. Deficiency of C2 has been associated with certain autoimmune diseases.

Language: English [EN]
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Complement component 2 topic overview

The analysis highlights Art, Function and Overview as prominent areas in the source structure around Complement component 2.

Related topics
15
Source areas
2
Connected nodes
17
Extracted relationships
116
Concept neighborhoods
10
Bridge connections
17

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Function · 8 topics
Overview · 7 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3.4.21.43
Aliases
C2, ARMD14, CO2, complement component 2, complement C2
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2I6S, 3ERB,%%s2ODQ
Band
6p21.33 · 17 B1|17 18.41 cM
Bgee
liver · right lobe of liver · placenta · spleen · upper lobe of left lung
BioGPS
More reference expression data

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Complement component 2 connects Entity context

The extracted context around Complement component 2 shows recurring relationship patterns in the source. For example, Complement component 2 → adrenal gland, appendix, decidua, duodenum, gallbladder, ileum, iris, left lobe of liver, liver, lumbar spinal ganglion, lymph node, mesenteric lymph nodes, placenta, right lobe of liver, right lung, sciatic nerve, spleen, tunica adventitia of aorta, upper lobe of left lung, white adipose tissue Another extracted example is Complement component 2 → complement activation, complement activation, classical pathway, extracellular exosome, extracellular region, extracellular space, hydrolase activity, immune system process, innate immune response, metal ion binding, peptidase activity, positive regulation of apoptotic cell clearance, protein binding, proteolysis, regulation of complement activation, response to nutrient, serine-type endopeptidase activity, serine-type peptidase activity. Use these groups to spot repeated connection types before inspecting the individual relationships.

Complement component 2

Top relations

Bgee · 20
Complement component 2 → adrenal gland, appendix, decidua, duodenum, gallbladder, ileum, iris, left lobe of liver, liver, lumbar spinal ganglion, lymph node, mesenteric lymph nodes, placenta, right lobe of liver, right lung, sciatic nerve, spleen, tunica adventitia of aorta, upper lobe of left lung, white adipose tissue
RNA expression pattern · 20
Complement component 2 → adrenal gland, appendix, decidua, duodenum, gallbladder, ileum, iris, left lobe of liver, liver, lumbar spinal ganglion, lymph node, mesenteric lymph nodes, placenta, right lobe of liver, right lung, sciatic nerve, spleen, tunica adventitia of aorta, upper lobe of left lung, white adipose tissue
Gene ontology · 17
Complement component 2 → complement activation, complement activation, classical pathway, extracellular exosome, extracellular region, extracellular space, hydrolase activity, immune system process, innate immune response, metal ion binding, peptidase activity, positive regulation of apoptotic cell clearance, protein binding, proteolysis, regulation of complement activation, response to nutrient, serine-type endopeptidase activity, serine-type peptidase activity
related to Development of SLE · 11
Complement component 2 → C2, C3, C4b2a, Complement, In C2, It, Lupus, MBL, SLE, Systemic, The
related to Complement Component 2 Deficiency · 10
Complement component 2 → Autosomal, C2, Complement, Complement Component, Deficiency, In, It, RNA, This, Using
related to Clinical Significance · 7
Complement component 2 → C2, C4, Clinically, Complement, LE, Patients, Photosensitive
related to Patient education · 4
Complement component 2 → C2, Early, Patients, Vaccination
Band · 2
Complement component 2 → 17 B1|17 18.41 cM, 6p21.33
Chr. · 2
Complement component 2 → Chromosome 17 (mouse), Chromosome 6 (human)
End · 2
Complement component 2 → 31,945,673 bp, 35,117,241 bp

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

complement deficiency component protein c2 system gene bp chr human band activation classical patients autoimmune chromosome immune response infection form

Complement component 2 relationships Subject–Predicate–Object triples

TTTA extracted 116 structured relationships around Complement component 2. Examples in this analysis include Complement component 2 → 3.4.21.43 → ↗ and Complement component 2 → Aliases → C2, ARMD14, CO2, complement component 2, complement C2. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Complement component 23.4.21.431.00infobox
Complement component 2AliasesC2, ARMD14, CO2, complement component 2, complement C21.00infobox
Complement component 2Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2I6S, 3ERB,%%s2ODQ1.00infobox
Complement component 2Band6p21.331.00infobox
Complement component 2Band17 B1|17 18.41 cM1.00infobox
Complement component 2Bgeeliver1.00infobox
Complement component 2Bgeeright lobe of liver1.00infobox
Complement component 2Bgeeplacenta1.00infobox
Complement component 2Bgeespleen1.00infobox
Complement component 2Bgeeupper lobe of left lung1.00infobox
Complement component 2Bgeegallbladder1.00infobox
Complement component 2Bgeeappendix1.00infobox
Complement component 2Bgeeright lung1.00infobox
Complement component 2Bgeelymph node1.00infobox
Complement component 2Bgeeduodenum1.00infobox
Complement component 2Bgeeiris1.00infobox
Complement component 2Bgeedecidua1.00infobox
Complement component 2Bgeeadrenal gland1.00infobox
Complement component 2Bgeewhite adipose tissue1.00infobox
Complement component 2Bgeeleft lobe of liver1.00infobox
Complement component 2Bgeetunica adventitia of aorta1.00infobox
Complement component 2Bgeelumbar spinal ganglion1.00infobox
Complement component 2Bgeemesenteric lymph nodes1.00infobox
Complement component 2Bgeesciatic nerve1.00infobox
Complement component 2Bgeeileum1.00infobox
Complement component 2BioGPSMore reference expression data1.00infobox
Complement component 2Chr.Chromosome 6 (human)1.00infobox
Complement component 2Chr.Chromosome 17 (mouse)1.00infobox
Complement component 2DatabasesNCBI: entry; OMA: entry1.00infobox
Complement component 2End31,945,673 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Complement component 2 bring nearby vocabulary together. In this analysis, examples include Component, Deficiency and System. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Complement component 2
    • Component
    • Deficiency
    • System
    • Protein
    • Gene
    • Activation
    • Immune
    • Risk
    • Care
    • Chromosome
    • Human
    • Bp
  • complement component 2
    • Component
    • Deficiency
    • System
    • Risk
    • Protein
    • Gene
    • Pathways
    • Response
    • Form
    • Immune
    • Activation
    • Function
  • gene
    • Location
    • Protein
    • Chromosome
    • Human
    • Bp
    • Chr
    • Function
    • Mouse
    • Classical
    • Component
    • Pathway
    • Band
  • classical pathway
    • Pathway
    • Pathways
    • Activation
    • C2a
    • C2b
    • Encoded
    • Function
    • Mouse
    • Process
    • Regulation
    • System
    • Gene
  • complement system
    • Component
    • Deficiency
    • System
    • Protein
    • Gene
    • Activation
    • Immune
    • Risk
    • Classical
    • Clinical
    • Pathways
    • Response
  • complement component 4
    • Component
    • Deficiency
    • System
    • Risk
    • Protein
    • Gene
    • Pathways
    • Response
    • Form
    • Immune
    • Activation
    • Function
  • complement activation
    • Component
    • Process
    • Deficiency
    • Classical
    • Pathways
    • Immune
    • System
    • Protein
    • C2
    • Function
    • Mouse
    • Regulation
  • protein
    • Response
    • System
    • Component
    • Process
    • Regulation
    • Pathways
    • Tissue
    • Activation
    • Form
    • Immune
    • Deficiency
    • Function

Connections between topic areas Semantic bridges

For Complement component 2, one of the stronger structural bridges in this analysis connects Complement component 2 with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Complement component 2Function · splits 9 ⟂ 9
Complement component 2Overview · splits 10 ⟂ 8

Map overview Semantic statistics

Complement component 2

Nodes18
Edges17
Triples116
Avg. degree1.89
Density0.111111
Components1

Source & methodology

TTTA analyzes the structure around Complement component 2 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Art, Function & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Complement component 2 · EN edition · Analysis: TopicsToTalkAbout

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