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Complement component 2

Complement C2 is a protein that in humans is encoded by the C2 gene. The protein encoded by this gene is part of the classical pathway of the complement system, acting as a multi-domain serine protease, which are a class of enzymes that cleave peptide bonds in other proteins. Deficiency of C2 has been associated with certain autoimmune diseases.

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3.4.21.43
Aliases
C2, ARMD14, CO2, complement component 2, complement C2
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2I6S, 3ERB,%%s2ODQ
Band
6p21.33 · 17 B1|17 18.41 cM
Bgee
liver · right lobe of liver · placenta · spleen · upper lobe of left lung
BioGPS
More reference expression data

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Complement component 2

Nodes18
Edges17
Triples116
Avg. degree1.89
Density0.111111
Components1

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Complement component 2

Top relations

Bgee · 20
Complement component 2 → adrenal gland, appendix, decidua, duodenum, gallbladder, ileum, iris, left lobe of liver, liver, lumbar spinal ganglion, lymph node, mesenteric lymph nodes, placenta, right lobe of liver, right lung, sciatic nerve, spleen, tunica adventitia of aorta, upper lobe of left lung, white adipose tissue
RNA expression pattern · 20
Complement component 2 → adrenal gland, appendix, decidua, duodenum, gallbladder, ileum, iris, left lobe of liver, liver, lumbar spinal ganglion, lymph node, mesenteric lymph nodes, placenta, right lobe of liver, right lung, sciatic nerve, spleen, tunica adventitia of aorta, upper lobe of left lung, white adipose tissue
Gene ontology · 17
Complement component 2 → complement activation, complement activation, classical pathway, extracellular exosome, extracellular region, extracellular space, hydrolase activity, immune system process, innate immune response, metal ion binding, peptidase activity, positive regulation of apoptotic cell clearance, protein binding, proteolysis, regulation of complement activation, response to nutrient, serine-type endopeptidase activity, serine-type peptidase activity
related to Development of SLE · 11
Complement component 2 → C2, C3, C4b2a, Complement, In C2, It, Lupus, MBL, SLE, Systemic, The
related to Complement Component 2 Deficiency · 10
Complement component 2 → Autosomal, C2, Complement, Complement Component, Deficiency, In, It, RNA, This, Using
related to Clinical Significance · 7
Complement component 2 → C2, C4, Clinically, Complement, LE, Patients, Photosensitive
related to Patient education · 4
Complement component 2 → C2, Early, Patients, Vaccination
Band · 2
Complement component 2 → 17 B1|17 18.41 cM, 6p21.33
Chr. · 2
Complement component 2 → Chromosome 17 (mouse), Chromosome 6 (human)
End · 2
Complement component 2 → 31,945,673 bp, 35,117,241 bp

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Important terminology

complement deficiency component protein c2 system gene bp chr human band activation classical patients autoimmune chromosome immune response infection form

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Complement component 23.4.21.431.00infobox
Complement component 2AliasesC2, ARMD14, CO2, complement component 2, complement C21.00infobox
Complement component 2Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2I6S, 3ERB,%%s2ODQ1.00infobox
Complement component 2Band6p21.331.00infobox
Complement component 2Band17 B1|17 18.41 cM1.00infobox
Complement component 2Bgeeliver1.00infobox
Complement component 2Bgeeright lobe of liver1.00infobox
Complement component 2Bgeeplacenta1.00infobox
Complement component 2Bgeespleen1.00infobox
Complement component 2Bgeeupper lobe of left lung1.00infobox
Complement component 2Bgeegallbladder1.00infobox
Complement component 2Bgeeappendix1.00infobox
Complement component 2Bgeeright lung1.00infobox
Complement component 2Bgeelymph node1.00infobox
Complement component 2Bgeeduodenum1.00infobox
Complement component 2Bgeeiris1.00infobox
Complement component 2Bgeedecidua1.00infobox
Complement component 2Bgeeadrenal gland1.00infobox
Complement component 2Bgeewhite adipose tissue1.00infobox
Complement component 2Bgeeleft lobe of liver1.00infobox
Complement component 2Bgeetunica adventitia of aorta1.00infobox
Complement component 2Bgeelumbar spinal ganglion1.00infobox
Complement component 2Bgeemesenteric lymph nodes1.00infobox
Complement component 2Bgeesciatic nerve1.00infobox
Complement component 2Bgeeileum1.00infobox
Complement component 2BioGPSMore reference expression data1.00infobox
Complement component 2Chr.Chromosome 6 (human)1.00infobox
Complement component 2Chr.Chromosome 17 (mouse)1.00infobox
Complement component 2DatabasesNCBI: entry; OMA: entry1.00infobox
Complement component 2End31,945,673 bp1.00infobox

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