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Bcl-2-like protein 2 is a 193-amino acid protein that in humans is encoded by the BCL2L2 gene on chromosome 14 (band q11.2-q12). It was originally discovered by Leonie Gibson, Suzanne Cory and colleagues at the Walter and Eliza Hall Institute of Medical Research, who called it Bcl-w.
The analysis highlights Clinical significance, Function and Interactions as prominent areas in the source structure around BCL2L2.
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
High-confidence facts extracted from structured source data. Use them as anchors for further research.
Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
The extracted context around BCL2L2 shows recurring relationship patterns in the source. For example, BCL2L2 → apoptotic process, Bcl-2 family protein complex, BH domain binding, cellular response to amyloid-beta, cellular response to estradiol stimulus, cytoplasm, cytosol, disordered domain specific binding, extrinsic apoptotic signaling pathway in absence of ligand, identical protein binding, intrinsic apoptotic signaling pathway in response to DNA damage, membrane, mitochondrial membranes, mitochondrial outer membrane, mitochondrion, negative regulation of apoptotic process, negative regulation of intrinsic apoptotic signaling pathway, nuclear inclusion body, nucleus, protein binding Another extracted example is BCL2L2 → amygdala, Brodmann area 9, C1 segment, cerebellar vermis, cingulate gyrus, habenula, lateral geniculate nucleus, lateral nuclear group of thalamus, lobe of cerebellum, medial dorsal nucleus, medial geniculate nucleus, medial vestibular nucleus, muscle layer of sigmoid colon, orbitofrontal cortex, pontine nuclei, postcentral gyrus, prefrontal cortex, right frontal lobe, subiculum, ventral tegmental area. Use these groups to spot repeated connection types before inspecting the individual relationships.
Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.
gene bcl-w band bp human chromosome 14 chr location shown protein mouse family cell function external spermatogenesis search 311 751
TTTA extracted 91 structured relationships around BCL2L2. Examples in this analysis include BCL2L2 → Aliases → BCL2L2, BCL-W, BCL2-L-2, BCLW, PPP1R51, BCL2 like 2 and BCL2L2 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1MK3, 1O0L, 1ZY3, 2Y6W, 4CIM. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| BCL2L2 | Aliases | BCL2L2, BCL-W, BCL2-L-2, BCLW, PPP1R51, BCL2 like 2 | 1.00 | infobox |
| BCL2L2 | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1MK3, 1O0L, 1ZY3, 2Y6W, 4CIM | 1.00 | infobox |
| BCL2L2 | Band | 14q11.2 | 1.00 | infobox |
| BCL2L2 | Band | 14 C3|14 27.98 cM | 1.00 | infobox |
| BCL2L2 | Bgee | C1 segment | 1.00 | infobox |
| BCL2L2 | Bgee | prefrontal cortex | 1.00 | infobox |
| BCL2L2 | Bgee | amygdala | 1.00 | infobox |
| BCL2L2 | Bgee | right frontal lobe | 1.00 | infobox |
| BCL2L2 | Bgee | postcentral gyrus | 1.00 | infobox |
| BCL2L2 | Bgee | lateral nuclear group of thalamus | 1.00 | infobox |
| BCL2L2 | Bgee | Brodmann area 9 | 1.00 | infobox |
| BCL2L2 | Bgee | orbitofrontal cortex | 1.00 | infobox |
| BCL2L2 | Bgee | cingulate gyrus | 1.00 | infobox |
| BCL2L2 | Bgee | muscle layer of sigmoid colon | 1.00 | infobox |
| BCL2L2 | Bgee | medial dorsal nucleus | 1.00 | infobox |
| BCL2L2 | Bgee | lobe of cerebellum | 1.00 | infobox |
| BCL2L2 | Bgee | habenula | 1.00 | infobox |
| BCL2L2 | Bgee | subiculum | 1.00 | infobox |
| BCL2L2 | Bgee | cerebellar vermis | 1.00 | infobox |
| BCL2L2 | Bgee | medial geniculate nucleus | 1.00 | infobox |
| BCL2L2 | Bgee | pontine nuclei | 1.00 | infobox |
| BCL2L2 | Bgee | ventral tegmental area | 1.00 | infobox |
| BCL2L2 | Bgee | medial vestibular nucleus | 1.00 | infobox |
| BCL2L2 | Bgee | lateral geniculate nucleus | 1.00 | infobox |
| BCL2L2 | BioGPS | More reference expression data | 1.00 | infobox |
| BCL2L2 | Chr. | Chromosome 14 (human) | 1.00 | infobox |
| BCL2L2 | Chr. | Chromosome 14 (mouse) | 1.00 | infobox |
| BCL2L2 | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| BCL2L2 | End | 23,311,751 bp | 1.00 | infobox |
| BCL2L2 | End | 55,125,691 bp | 1.00 | infobox |
The concept neighborhoods around BCL2L2 bring nearby vocabulary together. In this analysis, examples include Location, Chromosome and Human. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For BCL2L2, one of the stronger structural bridges in this analysis connects BCL2L2 with Clinical significance. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around BCL2L2 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Clinical significance, Function & Interactions, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — BCL2L2 · EN edition · Analysis: TopicsToTalkAbout