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BCL2L2: Clinical significance, Function & Interactions

Bcl-2-like protein 2 is a 193-amino acid protein that in humans is encoded by the BCL2L2 gene on chromosome 14 (band q11.2-q12). It was originally discovered by Leonie Gibson, Suzanne Cory and colleagues at the Walter and Eliza Hall Institute of Medical Research, who called it Bcl-w.

Language: English [EN]
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BCL2L2 topic overview

The analysis highlights Clinical significance, Function and Interactions as prominent areas in the source structure around BCL2L2.

Related topics
31
Source areas
4
Connected nodes
35
Extracted relationships
91
Concept neighborhoods
14
Bridge connections
35

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Clinical significance · 14 topics
Function · 7 topics
Overview · 6 topics
Interactions · 4 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
BCL2L2, BCL-W, BCL2-L-2, BCLW, PPP1R51, BCL2 like 2
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1MK3, 1O0L, 1ZY3, 2Y6W, 4CIM
Band
14q11.2 · 14 C3|14 27.98 cM
Bgee
C1 segment · prefrontal cortex · amygdala · right frontal lobe · postcentral gyrus
BioGPS
More reference expression data
Chr.
Chromosome 14 (human) · Chromosome 14 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Clinical significance

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How BCL2L2 connects Entity context

The extracted context around BCL2L2 shows recurring relationship patterns in the source. For example, BCL2L2 → apoptotic process, Bcl-2 family protein complex, BH domain binding, cellular response to amyloid-beta, cellular response to estradiol stimulus, cytoplasm, cytosol, disordered domain specific binding, extrinsic apoptotic signaling pathway in absence of ligand, identical protein binding, intrinsic apoptotic signaling pathway in response to DNA damage, membrane, mitochondrial membranes, mitochondrial outer membrane, mitochondrion, negative regulation of apoptotic process, negative regulation of intrinsic apoptotic signaling pathway, nuclear inclusion body, nucleus, protein binding Another extracted example is BCL2L2 → amygdala, Brodmann area 9, C1 segment, cerebellar vermis, cingulate gyrus, habenula, lateral geniculate nucleus, lateral nuclear group of thalamus, lobe of cerebellum, medial dorsal nucleus, medial geniculate nucleus, medial vestibular nucleus, muscle layer of sigmoid colon, orbitofrontal cortex, pontine nuclei, postcentral gyrus, prefrontal cortex, right frontal lobe, subiculum, ventral tegmental area. Use these groups to spot repeated connection types before inspecting the individual relationships.

BCL2L2

Top relations

Gene ontology · 25
BCL2L2 → apoptotic process, Bcl-2 family protein complex, BH domain binding, cellular response to amyloid-beta, cellular response to estradiol stimulus, cytoplasm, cytosol, disordered domain specific binding, extrinsic apoptotic signaling pathway in absence of ligand, identical protein binding, intrinsic apoptotic signaling pathway in response to DNA damage, membrane, mitochondrial membranes, mitochondrial outer membrane, mitochondrion, negative regulation of apoptotic process, negative regulation of intrinsic apoptotic signaling pathway, nuclear inclusion body, nucleus, protein binding
Bgee · 20
BCL2L2 → amygdala, Brodmann area 9, C1 segment, cerebellar vermis, cingulate gyrus, habenula, lateral geniculate nucleus, lateral nuclear group of thalamus, lobe of cerebellum, medial dorsal nucleus, medial geniculate nucleus, medial vestibular nucleus, muscle layer of sigmoid colon, orbitofrontal cortex, pontine nuclei, postcentral gyrus, prefrontal cortex, right frontal lobe, subiculum, ventral tegmental area
RNA expression pattern · 20
BCL2L2 → amygdala, Brodmann area 9, C1 segment, cerebellar vermis, cingulate gyrus, habenula, lateral geniculate nucleus, lateral nuclear group of thalamus, lobe of cerebellum, medial dorsal nucleus, medial geniculate nucleus, medial vestibular nucleus, muscle layer of sigmoid colon, orbitofrontal cortex, pontine nuclei, postcentral gyrus, prefrontal cortex, right frontal lobe, subiculum, ventral tegmental area
Band · 2
BCL2L2 → 14 C3|14 27.98 cM, 14q11.2
Chr. · 2
BCL2L2 → Chromosome 14 (human), Chromosome 14 (mouse)
End · 2
BCL2L2 → 23,311,751 bp, 55,125,691 bp
related to External links · 2
BCL2L2 → Human BCL2L2, UCSC Genome Browser
Aliases · 1
BCL2L2 → BCL2L2, BCL-W, BCL2-L-2, BCLW, PPP1R51, BCL2 like 2
Available structures · 1
BCL2L2 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1MK3, 1O0L, 1ZY3, 2Y6W, 4CIM
BioGPS · 1
BCL2L2 → More reference expression data

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

gene bcl-w band bp human chromosome 14 chr location shown protein mouse family cell function external spermatogenesis search 311 751

BCL2L2 relationships Subject–Predicate–Object triples

TTTA extracted 91 structured relationships around BCL2L2. Examples in this analysis include BCL2L2 → Aliases → BCL2L2, BCL-W, BCL2-L-2, BCLW, PPP1R51, BCL2 like 2 and BCL2L2 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1MK3, 1O0L, 1ZY3, 2Y6W, 4CIM. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
BCL2L2AliasesBCL2L2, BCL-W, BCL2-L-2, BCLW, PPP1R51, BCL2 like 21.00infobox
BCL2L2Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1MK3, 1O0L, 1ZY3, 2Y6W, 4CIM1.00infobox
BCL2L2Band14q11.21.00infobox
BCL2L2Band14 C3|14 27.98 cM1.00infobox
BCL2L2BgeeC1 segment1.00infobox
BCL2L2Bgeeprefrontal cortex1.00infobox
BCL2L2Bgeeamygdala1.00infobox
BCL2L2Bgeeright frontal lobe1.00infobox
BCL2L2Bgeepostcentral gyrus1.00infobox
BCL2L2Bgeelateral nuclear group of thalamus1.00infobox
BCL2L2BgeeBrodmann area 91.00infobox
BCL2L2Bgeeorbitofrontal cortex1.00infobox
BCL2L2Bgeecingulate gyrus1.00infobox
BCL2L2Bgeemuscle layer of sigmoid colon1.00infobox
BCL2L2Bgeemedial dorsal nucleus1.00infobox
BCL2L2Bgeelobe of cerebellum1.00infobox
BCL2L2Bgeehabenula1.00infobox
BCL2L2Bgeesubiculum1.00infobox
BCL2L2Bgeecerebellar vermis1.00infobox
BCL2L2Bgeemedial geniculate nucleus1.00infobox
BCL2L2Bgeepontine nuclei1.00infobox
BCL2L2Bgeeventral tegmental area1.00infobox
BCL2L2Bgeemedial vestibular nucleus1.00infobox
BCL2L2Bgeelateral geniculate nucleus1.00infobox
BCL2L2BioGPSMore reference expression data1.00infobox
BCL2L2Chr.Chromosome 14 (human)1.00infobox
BCL2L2Chr.Chromosome 14 (mouse)1.00infobox
BCL2L2DatabasesNCBI: entry; OMA: entry1.00infobox
BCL2L2End23,311,751 bp1.00infobox
BCL2L2End55,125,691 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around BCL2L2 bring nearby vocabulary together. In this analysis, examples include Location, Chromosome and Human. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • BCL2L2
    • Location
    • Chromosome
    • Human
    • Function
    • Gene
    • Protein
    • Search
    • Ucsc
    • Band
    • Bp
    • Chr
    • Bcl-2
  • bcl2l2
    • Location
    • Chromosome
    • Human
    • Function
    • Gene
    • Protein
    • Search
    • Ucsc
    • Band
    • Bp
    • Chr
    • Bcl-2
  • gene
    • Location
    • Chromosome
    • Human
    • Mouse
    • Band
    • Bp
    • Chr
    • C3
    • End
    • Expression
    • Function
    • Protein
  • chromosome 14
    • Band
    • Bp
    • Chr
    • Human
    • Location
    • C3
    • End
    • Function
    • Gene
    • Protein
    • Search
    • Mouse
  • band
    • Bp
    • Chr
    • Chromosome
    • Human
    • C3
    • End
    • Protein
    • Mouse
    • Location
    • Gene
    • Bcl2l2
    • Bcl-2
  • bcl-2 protein family
    • C3
    • Cellular
    • End
    • Expression
    • Family
    • Function
    • Pathway
    • Protein
    • Search
    • Spermatogenesis
    • Ucsc
    • Cell
  • function
    • Search
    • Bcl-2
    • Location
    • Bp
    • Chr
    • Human
    • C3
    • Cellular
    • End
    • Expression
    • Family
    • Pathway
  • cellular senescence
    • Contribute
    • End
    • Expression
    • Family
    • Function
    • Pathway
    • Protein
    • Search
    • Spermatogenesis
    • Ucsc
    • Mouse
    • Location

Connections between topic areas Semantic bridges

For BCL2L2, one of the stronger structural bridges in this analysis connects BCL2L2 with Clinical significance. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
BCL2L2Clinical significance · splits 21 ⟂ 15
BCL2L2Function · splits 28 ⟂ 8
BCL2L2Overview · splits 29 ⟂ 7
BCL2L2Interactions · splits 31 ⟂ 5

Map overview Semantic statistics

BCL2L2

Nodes36
Edges35
Triples91
Avg. degree1.94
Density0.055556
Components1

Source & methodology

TTTA analyzes the structure around BCL2L2 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Clinical significance, Function & Interactions, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — BCL2L2 · EN edition · Analysis: TopicsToTalkAbout

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