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TPX2

Targeting protein for Xklp2 is a protein that in humans is encoded by the TPX2 gene. It is one of the many spindle assembly factors that play a key role in inducing microtubule assembly and growth during M phase.

Regions, Role in microtubule assembly & Key domains of TPX2

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Aliases
TPX2, C20orf1, C20orf2, DIL-2, DIL2, FLS353, GD:C20orf1, HCA519, HCTP4, REPP86, p100, microtubule nucleation factor, TPX2 microtubule nucleation factor
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1OL5, 3E5A, 3HA6, 4C3P
Band
20q11.21 · 2|2 H1
Bgee
ventricular zone · ganglionic eminence · oocyte · gonad · secondary oocyte
BioGPS
More reference expression data
Chr.
Chromosome 20 (human) · Chromosome 2 (mouse)

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Overview

Key domains of TPX2

Role in microtubule assembly

Activation and reciprocation through Aurora A kinase

Role in cleavage arrest and interaction with Eg5

Regulation of TPX2 in the cell cycle

Role in the nucleus

Relevance in cancer

Advanced semantic analysis

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Map overview Semantic statistics

TPX2

Nodes62
Edges61
Triples178
Avg. degree1.97
Density0.032258
Components1

How this topic connects Entity context

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TPX2

Top relations

Gene ontology · 28
TPX2 → activation of protein kinase activity, apoptotic process, ATP binding, axon hillock, cell cycle, cell division, cell population proliferation, cytoplasm, cytoskeleton, cytosol, GTP binding, importin-alpha family protein binding, intercellular bridge, microtubule, microtubule cytoskeleton, microtubule organizing center, mitotic cell cycle, mitotic spindle, mitotic spindle assembly, nucleoplasm
Bgee · 18
TPX2 → bone marrow, endothelial cell of lymphatic vessel, epiblast, fetal liver hematopoietic progenitor cell, ganglionic eminence, genital tubercle, gonad, left testis, oocyte, primary oocyte, primitive streak, right testis, secondary oocyte, tail of embryo, testicle, trabecular bone, ventricular zone, zygote
RNA expression pattern · 18
TPX2 → bone marrow, endothelial cell of lymphatic vessel, epiblast, fetal liver hematopoietic progenitor cell, ganglionic eminence, genital tubercle, gonad, left testis, oocyte, primary oocyte, primitive streak, right testis, secondary oocyte, tail of embryo, testicle, trabecular bone, ventricular zone, zygote
related to Key domains of TPX2 · 18
TPX2 → APC/C, Both, Cdh1, Cell Cycle, D-box, Eg5, FKARP, However, In, K-E-N, KEN, Lastly, N-terminal, NLS, NLS-containing, R-X-X-L, Regulation, This
related to Regulation of TPX2 in the cell cycle · 15
TPX2 → APC/C, APC/C's, APC/CCdh1, Cdc20, Cdh1, Cdh1-TPX2, G1, G2/M, HeLa, Monitoring TPX2, Moreover, Overall, S-phase, The, This
related to Role in the nucleus · 15
TPX2 → DMSO, DNA, H2AX, However, M-phase, MDC1, Note, One, RanGTP, The, This, Though, TPX2's, When, Xenopus
related to Role in cleavage arrest and interaction with Eg5 · 12
TPX2 → Because, DNA, During, Eg5, Eg5-dependent, Instead, Notably, The, This, TPX2's, When, When Eg5
related to Relevance in cancer · 10
TPX2 → As, Because, EC9706, G1, HCC, In HCC, RNA, Similar, So, Studies
related to Role in microtubule assembly · 10
TPX2 → Aurora, HeLa, In, It, M-phase, MAP, RanGTP, RanGTP-induced, This, Xenopus
related to Activation and reciprocation through Aurora A kinase · 6
TPX2 → Activated Aurora, Aurora, Aurora A's, More, Notably, PP1

Important terminology Word statistics

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Important terminology

microtubule spindle protein nucleation cell assembly cells binding human amino shown bp mitotic kinase cleavage microtubules gene aurora cancer role

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
TPX2AliasesTPX2, C20orf1, C20orf2, DIL-2, DIL2, FLS353, GD:C20orf1, HCA519, HCTP4, REPP86, p100, microtubule nucleation factor, TPX2 microtubule nucleation factor1.00infobox
TPX2Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1OL5, 3E5A, 3HA6, 4C3P1.00infobox
TPX2Band20q11.211.00infobox
TPX2Band2|2 H11.00infobox
TPX2Bgeeventricular zone1.00infobox
TPX2Bgeeganglionic eminence1.00infobox
TPX2Bgeeoocyte1.00infobox
TPX2Bgeegonad1.00infobox
TPX2Bgeesecondary oocyte1.00infobox
TPX2Bgeebone marrow1.00infobox
TPX2Bgeetesticle1.00infobox
TPX2Bgeetrabecular bone1.00infobox
TPX2Bgeeright testis1.00infobox
TPX2Bgeeleft testis1.00infobox
TPX2Bgeetail of embryo1.00infobox
TPX2Bgeegenital tubercle1.00infobox
TPX2Bgeezygote1.00infobox
TPX2Bgeefetal liver hematopoietic progenitor cell1.00infobox
TPX2Bgeeprimitive streak1.00infobox
TPX2Bgeeepiblast1.00infobox
TPX2Bgeeendothelial cell of lymphatic vessel1.00infobox
TPX2Bgeeprimary oocyte1.00infobox
TPX2BioGPSMore reference expression data1.00infobox
TPX2Chr.Chromosome 20 (human)1.00infobox
TPX2Chr.Chromosome 2 (mouse)1.00infobox
TPX2DatabasesNCBI: entry; OMA: entry1.00infobox
TPX2End31,801,805 bp1.00infobox
TPX2End152,737,241 bp1.00infobox
TPX2EnsemblENSG000000883251.00infobox
TPX2Entrez229741.00infobox

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