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Amiloride: History, Community, Culture & Applications

Amiloride, sold under the trade name Midamor among others, is a medication typically used with other medications to treat high blood pressure or swelling due to heart failure or cirrhosis of the liver. Amiloride is classified as a potassium-sparing diuretic. Amiloride is often used together with another diuretic, such as a thiazide or loop diuretic. It…

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Amiloride topic overview

The analysis highlights History, Community, Culture and Applications as prominent areas in the source structure around Amiloride.

Related topics
108
Source areas
10
Connected nodes
118
Extracted relationships
106
Concept neighborhoods
39
Bridge connections
118

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 51 topics
Medical uses · 22 topics
Research · 9 topics
Society and culture · 7 topics
Adverse effects · 6 topics
Chemistry · 6 topics
Interactions · 3 topics
Pharmacology · 2 topics
Contraindications · 1 topics
History · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
C03DB01 (WHO)
Bioavailability
Readily absorbed, 15–25%
CAS Number
2016-88-8 Y
ChEBI
CHEBI:2639 Y

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Medical uses

Contraindications

Adverse effects

Interactions

Pharmacology

Chemistry

History

Society and culture

Research

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Amiloride connects Entity context

The extracted context around Amiloride shows recurring relationship patterns in the source. For example, Amiloride → Aerosolized, Cancer, CFTR, Cystic, DMA, Due, EIPA, ENaC, HMA, However, Modified, N'-4, N-dimethyl, N-ethyl-N-isopropyl, N-hexamethylene, NHE-1, There Another extracted example is Amiloride → ACE-i, American College, ARB, Because Liddle, Cardiology/American Heart Association Task, Clinical Practice Guidelines, Digitalis, ENaC, For, Force, II, Liddle, Some, The, When. Use these groups to spot repeated connection types before inspecting the individual relationships.

Amiloride

Top relations

related to Research · 17
Amiloride → Aerosolized, Cancer, CFTR, Cystic, DMA, Due, EIPA, ENaC, HMA, However, Modified, N'-4, N-dimethyl, N-ethyl-N-isopropyl, N-hexamethylene, NHE-1, There
related to Medical uses · 15
Amiloride → ACE-i, American College, ARB, Because Liddle, Cardiology/American Heart Association Task, Clinical Practice Guidelines, Digitalis, ENaC, For, Force, II, Liddle, Some, The, When
related to External links · 8
Amiloride → Archived, Drug Information Portal, January, Media, Medicine, National Library, Wikimedia Commons, Wiktionary-logo-en-v2
related to history · 8
Amiloride → Dohme Research Laboratories, Drug Administration, FDA, Food, Merck Sharp, October, The, Thousands
related to Society and culture · 7
Amiloride → Diuretics, Essential Medicines, In, It, The, World Anti-Doping Agency's, World Health Organization's List
related to Interactions · 4
Amiloride → ACE, AT1, For, II
Legal status · 3
Amiloride → AU: S4 (Prescription only), UK: POM (Prescription only), US: ℞-only
related to Overdose · 3
Amiloride → It, There, Treatment
has effect · 2
Amiloride → Common, Mild
related to Chemistry · 2
Amiloride → Amiloride's, In

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

potassium blood effects high sodium due enac kidney people used hyperkalemia risk diuretic drug potassium-sparing action excretion may channel thiazide

Amiloride relationships Subject–Predicate–Object triples

TTTA extracted 106 structured relationships around Amiloride. Examples in this analysis include Amiloride → 3D model (JSmol) → Interactive image and Amiloride → AHFS/Drugs.com → Monograph. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Amiloride3D model (JSmol)Interactive image1.00infobox
AmilorideAHFS/Drugs.comMonograph1.00infobox
AmilorideATC codeC03DB01 (WHO)1.00infobox
AmilorideBioavailabilityReadily absorbed, 15–25%1.00infobox
AmilorideCAS Number2016-88-8 Y1.00infobox
AmilorideChEBICHEBI:2639 Y1.00infobox
AmilorideChEMBLChEMBL945 Y1.00infobox
AmilorideChemSpider15403 Y1.00infobox
AmilorideCompTox Dashboard (EPA)DTXSID90438531.00infobox
AmilorideDrugBankDB00594 Y1.00infobox
AmilorideECHA InfoCard100.018.2051.00infobox
AmilorideElimination half-life6 to 9 hours1.00infobox
AmilorideExcretionurine (20–50%), feces (40%)1.00infobox
AmilorideFormulaC6H8ClN7O1.00infobox
AmilorideIUPHAR/BPS24211.00infobox
AmilorideKEGGD07447 Y1.00infobox
AmilorideLegal statusAU: S4 (Prescription only)1.00infobox
AmilorideLegal statusUK: POM (Prescription only)1.00infobox
AmilorideLegal statusUS: ℞-only1.00infobox
AmilorideMelting point240.5 to 241.5 °C (464.9 to 466.7 °F)1.00infobox
AmilorideMetabolismNil1.00infobox
AmilorideMolar mass229.63 g·mol−11.00infobox
AmilorideOnset of action2 hours (peak at 6–10 hours, duration ~24 hours)1.00infobox
AmilorideOther namesMK-8701.00infobox
AmiloridePregnancy categoryAU: C1.00infobox
AmilorideProtein binding~23%1.00infobox
AmiloridePubChem CID162311.00infobox
AmilorideRoutes of administrationBy mouth1.00infobox
AmilorideTrade namesMidamor, others1.00infobox
AmilorideUNII7M458Q65S31.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Amiloride bring nearby vocabulary together. In this analysis, examples include Effects, Blood and Potassium. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Amiloride
    • Effects
    • Blood
    • Potassium
    • Used
    • Due
    • May
    • Pressure
    • Diuretic
    • Sodium
    • Though
    • Treatment
    • Channel
  • amiloride
    • Effects
    • Blood
    • Potassium
    • Used
    • Due
    • May
    • Pressure
    • Diuretic
    • Sodium
    • Though
    • Treatment
    • Channel
  • high blood pressure
    • Blood
    • High
    • Potassium
    • Trade
    • Pressure
    • Heart
    • Kidney
    • Risk
    • Thiazide
    • People
    • Treatment
    • May
  • potassium-sparing diuretic
    • Thiazide
    • Triamterene
    • Hours
    • Used
    • Spironolactone
    • Taking
    • Pressure
    • Also
    • Hyperkalemia
    • Potassium-sparing
    • Trade
    • Effects
  • high blood potassium
    • Blood
    • High
    • Potassium
    • Pressure
    • Heart
    • People
    • Kidney
    • Risk
    • Excretion
    • Potassium-sparing
    • May
    • Hyperkalemia
  • blood urea nitrogen
    • High
    • Potassium
    • Pressure
    • Kidney
    • People
    • Hyperkalemia
    • May
    • Effects
    • Normal
    • Heart
    • Risk
    • Trade
  • potassium
    • People
    • Excretion
    • Potassium-sparing
    • Kidney
    • Sodium
    • Diabetes
    • Use
    • Hyperkalemia
    • Risk
    • Normal
    • Side
    • Taking
  • adverse effects
    • Side
    • Normal
    • Potassium
    • Enac
    • Collecting
    • Excretion
    • Hours
    • Thiazide
    • Pressure
    • Though
    • Diuretics
    • Use

Connections between topic areas Semantic bridges

For Amiloride, one of the stronger structural bridges in this analysis connects Amiloride with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Amiloride — Overview · splits 67 ⟂ 52
Amiloride — Medical uses · splits 96 ⟂ 23
Amiloride — Research · splits 109 ⟂ 10
Amiloride — Society and culture · splits 111 ⟂ 8
Amiloride — Adverse effects · splits 112 ⟂ 7
Amiloride — Chemistry · splits 112 ⟂ 7
Amiloride — Interactions · splits 115 ⟂ 4
Amiloride — Pharmacology · splits 116 ⟂ 3

Map overview Semantic statistics

Amiloride

Nodes119
Edges118
Triples106
Avg. degree1.98
Density0.016807
Components1

Source & methodology

TTTA analyzes the structure around Amiloride to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History, Community, Culture & Applications, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Amiloride · EN edition · Analysis: TopicsToTalkAbout

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