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NEDD4L

Neural precursor cell expressed developmentally downregulated gene 4-like (NEDD4L) or NEDD4-2 is an enzyme (ubiquitin ligase) of the NEDD4 family. In human the protein is encoded by the NEDD4L gene. In mouse the protein is commonly known as NEDD4-2 and the gene Nedd4-2.

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13 related topics

Interactions

2 related topics

Expression

1 related topics

Clinical significance

1 related topics

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2.3.2.26
2.3.2.36
Aliases
NEDD4L, NEDD4-2, NEDD4.2, RSP5, hNEDD4-2, neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase, PVNH7, NEDD4 like E3 ubiquitin pro…
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2LAJ, 2LB2, 2LTY, 2MPT, 2NSQ, 2ONI, 3JVZ, 3JW0, 5HPK
Band
18q21.31 · 18|18 E1
Bgee
ventricular zone · ganglionic eminence · olfactory zone of nasal mucosa · right lung · secondary oocyte

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Expression

Clinical significance

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Map overview Semantic statistics

NEDD4L

Nodes22
Edges21
Triples148
Avg. degree1.91
Density0.090909
Components1

How this topic connects Entity context

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NEDD4L

Top relations

Gene ontology · 52
NEDD4L → cell differentiation, cellular sodium ion homeostasis, cytoplasm, cytosol, endosome, excretion, extracellular exosome, Golgi apparatus, intracellular anatomical structure, ion transmembrane transport, multivesicular body, negative regulation of potassium ion transmembrane transport, negative regulation of potassium ion transmembrane transporter activity, negative regulation of protein localization to cell surface, negative regulation of sodium ion transmembrane transport, negative regulation of sodium ion transmembrane transporter activity, negative regulation of transcription by RNA polymerase II, nucleoplasm, plasma membrane, positive regulation of caveolin-mediated endocytosis
Bgee · 19
NEDD4L → anterior amygdaloid area, body of pancreas, epithelium of colon, ganglionic eminence, habenula, human kidney, lateral septal nucleus, left lung lobe, mammillary body, nucleus accumbens, olfactory tubercle, olfactory zone of nasal mucosa, rectum, right lung, Rostral migratory stream, secondary oocyte, upper lobe of left lung, ventricular zone, zygote
RNA expression pattern · 19
NEDD4L → anterior amygdaloid area, body of pancreas, epithelium of colon, ganglionic eminence, habenula, human kidney, lateral septal nucleus, left lung lobe, mammillary body, nucleus accumbens, olfactory tubercle, olfactory zone of nasal mucosa, rectum, right lung, Rostral migratory stream, secondary oocyte, upper lobe of left lung, ventricular zone, zygote
related to Function · 12
NEDD4L → E2, E3, EGFR, ENaC, However, In, It, Navs, NCC, NEDD4-2, TGFβ, WNT
related to Clinical significance · 11
NEDD4L → Also NEDD4-2-deficiency, Consistent, DRG, ENaC, In, Isolated, Liddle's, NCC, NEDD4-2, NEDDL, Specific
related to Expression · 8
NEDD4L → C2, Human NEDD4L, II, III, Isoform, NEDD4-2, The, Three
Band · 2
NEDD4L → 18q21.31, 18|18 E1
Chr. · 2
NEDD4L → Chromosome 18 (human), Chromosome 18 (mouse)
End · 2
NEDD4L → 58,401,540 bp, 65,217,828 bp
2.3.2.26 · 1
NEDD4L → ↗

Important terminology Word statistics

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Important terminology

nedd4-2 gene protein human nedd4 enac proteins ubiquitin bp mouse expressed chr band ligase chromosome sodium expression regulation ncc cell

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
NEDD4L2.3.2.261.00infobox
NEDD4L2.3.2.361.00infobox
NEDD4LAliasesNEDD4L, NEDD4-2, NEDD4.2, RSP5, hNEDD4-2, neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase, PVNH7, NEDD4 like E3 ubiquitin pro…1.00infobox
NEDD4LAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2LAJ, 2LB2, 2LTY, 2MPT, 2NSQ, 2ONI, 3JVZ, 3JW0, 5HPK1.00infobox
NEDD4LBand18q21.311.00infobox
NEDD4LBand18|18 E11.00infobox
NEDD4LBgeeventricular zone1.00infobox
NEDD4LBgeeganglionic eminence1.00infobox
NEDD4LBgeeolfactory zone of nasal mucosa1.00infobox
NEDD4LBgeeright lung1.00infobox
NEDD4LBgeesecondary oocyte1.00infobox
NEDD4LBgeebody of pancreas1.00infobox
NEDD4LBgeeupper lobe of left lung1.00infobox
NEDD4LBgeerectum1.00infobox
NEDD4LBgeeepithelium of colon1.00infobox
NEDD4LBgeehuman kidney1.00infobox
NEDD4LBgeeRostral migratory stream1.00infobox
NEDD4LBgeeolfactory tubercle1.00infobox
NEDD4LBgeezygote1.00infobox
NEDD4LBgeemammillary body1.00infobox
NEDD4LBgeenucleus accumbens1.00infobox
NEDD4LBgeehabenula1.00infobox
NEDD4LBgeeanterior amygdaloid area1.00infobox
NEDD4LBgeelateral septal nucleus1.00infobox
NEDD4LBgeeleft lung lobe1.00infobox
NEDD4LBioGPSn/a1.00infobox
NEDD4LChr.Chromosome 18 (human)1.00infobox
NEDD4LChr.Chromosome 18 (mouse)1.00infobox
NEDD4LDatabasesNCBI: entry; OMA: entry1.00infobox
NEDD4LEnd58,401,540 bp1.00infobox

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