NEDD4L

Use the mouse wheel or two fingers (on touchscreens) to zoom in and out of the map.

Map view:

Zoom: 100%

More settings

Connection length 100% Label size 100% Node size 100% Line width 100% Label width 100%

Export map as:

NEDD4L topic overview

The analysis highlights Overview, Interactions and Expression as prominent areas in the source structure around NEDD4L. 1 topic appears in more than one source area, which can help identify connections that are less obvious in a linear reading.

Related topics: 16
Source areas: 4
Connected nodes: 21
Extracted relationships: 148
Concept neighborhoods: 10
Bridge connections: 21

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 13 topics

Interactions · 2 topics

Clinical significance · 1 topics

Expression · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

2.3.2.26: ↗
2.3.2.36: ↗
Aliases: NEDD4L, NEDD4-2, NEDD4.2, RSP5, hNEDD4-2, neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase, PVNH7, NEDD4 like E3 ubiquitin pro…
Available structures: Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2LAJ, 2LB2, 2LTY, 2MPT, 2NSQ, 2ONI, 3JVZ, 3JW0, 5HPK
Band: 18q21.31 · 18|18 E1
Bgee: ventricular zone · ganglionic eminence · olfactory zone of nasal mucosa · right lung · secondary oocyte

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Expression

Start codon

Clinical significance

Liddle's syndrome

Interactions

Interact Protein-protein interaction
SCNN1A

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How NEDD4L connects Entity context

The extracted context around NEDD4L shows recurring relationship patterns in the source. For example, NEDD4L → cell differentiation, cellular sodium ion homeostasis, cytoplasm, cytosol, endosome, excretion, extracellular exosome, Golgi apparatus, intracellular anatomical structure, ion transmembrane transport, multivesicular body, negative regulation of potassium ion transmembrane transport, negative regulation of potassium ion transmembrane transporter activity, negative regulation of protein localization to cell surface, negative regulation of sodium ion transmembrane transport, negative regulation of sodium ion transmembrane transporter activity, negative regulation of transcription by RNA polymerase II, nucleoplasm, plasma membrane, positive regulation of caveolin-mediated endocytosis Another extracted example is NEDD4L → anterior amygdaloid area, body of pancreas, epithelium of colon, ganglionic eminence, habenula, human kidney, lateral septal nucleus, left lung lobe, mammillary body, nucleus accumbens, olfactory tubercle, olfactory zone of nasal mucosa, rectum, right lung, Rostral migratory stream, secondary oocyte, upper lobe of left lung, ventricular zone, zygote. Use these groups to spot repeated connection types before inspecting the individual relationships.

Top relations

Gene ontology · 52

NEDD4L → cell differentiation, cellular sodium ion homeostasis, cytoplasm, cytosol, endosome, excretion, extracellular exosome, Golgi apparatus, intracellular anatomical structure, ion transmembrane transport, multivesicular body, negative regulation of potassium ion transmembrane transport, negative regulation of potassium ion transmembrane transporter activity, negative regulation of protein localization to cell surface, negative regulation of sodium ion transmembrane transport, negative regulation of sodium ion transmembrane transporter activity, negative regulation of transcription by RNA polymerase II, nucleoplasm, plasma membrane, positive regulation of caveolin-mediated endocytosis

Bgee · 19

NEDD4L → anterior amygdaloid area, body of pancreas, epithelium of colon, ganglionic eminence, habenula, human kidney, lateral septal nucleus, left lung lobe, mammillary body, nucleus accumbens, olfactory tubercle, olfactory zone of nasal mucosa, rectum, right lung, Rostral migratory stream, secondary oocyte, upper lobe of left lung, ventricular zone, zygote

RNA expression pattern · 19

related to Function · 12

NEDD4L → E2, E3, EGFR, ENaC, However, In, It, Navs, NCC, NEDD4-2, TGFβ, WNT

related to Clinical significance · 11

NEDD4L → Also NEDD4-2-deficiency, Consistent, DRG, ENaC, In, Isolated, Liddle's, NCC, NEDD4-2, NEDDL, Specific

related to Expression · 8

NEDD4L → C2, Human NEDD4L, II, III, Isoform, NEDD4-2, The, Three

Band · 2

NEDD4L → 18q21.31, 18|18 E1

Chr. · 2

NEDD4L → Chromosome 18 (human), Chromosome 18 (mouse)

End · 2

NEDD4L → 58,401,540 bp, 65,217,828 bp

2.3.2.26 · 1

NEDD4L → ↗

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

nedd4-2 gene protein human nedd4 enac proteins ubiquitin bp mouse expressed chr band ligase chromosome sodium expression regulation ncc cell

NEDD4L relationships Subject–Predicate–Object triples

TTTA extracted 148 structured relationships around NEDD4L. Examples in this analysis include NEDD4L → 2.3.2.26 → ↗ and NEDD4L → Aliases → NEDD4L, NEDD4-2, NEDD4.2, RSP5, hNEDD4-2, neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase, PVNH7, NEDD4 like E3 ubiquitin pro…. The table shows each extracted connection, where it came from and its confidence.

Subject	Predicate	Object	Confidence	Src
NEDD4L	2.3.2.26	↗	1.00	infobox
NEDD4L	2.3.2.36	↗	1.00	infobox
NEDD4L	Aliases	NEDD4L, NEDD4-2, NEDD4.2, RSP5, hNEDD4-2, neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase, PVNH7, NEDD4 like E3 ubiquitin pro…	1.00	infobox
NEDD4L	Available structures	Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2LAJ, 2LB2, 2LTY, 2MPT, 2NSQ, 2ONI, 3JVZ, 3JW0, 5HPK	1.00	infobox
NEDD4L	Band	18q21.31	1.00	infobox
NEDD4L	Band	18\|18 E1	1.00	infobox
NEDD4L	Bgee	ventricular zone	1.00	infobox
NEDD4L	Bgee	ganglionic eminence	1.00	infobox
NEDD4L	Bgee	olfactory zone of nasal mucosa	1.00	infobox
NEDD4L	Bgee	right lung	1.00	infobox
NEDD4L	Bgee	secondary oocyte	1.00	infobox
NEDD4L	Bgee	body of pancreas	1.00	infobox
NEDD4L	Bgee	upper lobe of left lung	1.00	infobox
NEDD4L	Bgee	rectum	1.00	infobox
NEDD4L	Bgee	epithelium of colon	1.00	infobox
NEDD4L	Bgee	human kidney	1.00	infobox
NEDD4L	Bgee	Rostral migratory stream	1.00	infobox
NEDD4L	Bgee	olfactory tubercle	1.00	infobox
NEDD4L	Bgee	zygote	1.00	infobox
NEDD4L	Bgee	mammillary body	1.00	infobox
NEDD4L	Bgee	nucleus accumbens	1.00	infobox
NEDD4L	Bgee	habenula	1.00	infobox
NEDD4L	Bgee	anterior amygdaloid area	1.00	infobox
NEDD4L	Bgee	lateral septal nucleus	1.00	infobox
NEDD4L	Bgee	left lung lobe	1.00	infobox
NEDD4L	BioGPS	n/a	1.00	infobox
NEDD4L	Chr.	Chromosome 18 (human)	1.00	infobox
NEDD4L	Chr.	Chromosome 18 (mouse)	1.00	infobox
NEDD4L	Databases	NCBI: entry; OMA: entry	1.00	infobox
NEDD4L	End	58,401,540 bp	1.00	infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around NEDD4L bring nearby vocabulary together. In this analysis, examples include Ubiquitin, Human and Ligase. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

NEDD4L
- Ubiquitin
- Human
- Ligase
- Nedd4
- Protein
- E3
- Ubiquitination
- Domain
- Chromosome
- Proteins
- Function
- Location
nedd4l
- Ubiquitin
- Human
- Ligase
- Nedd4
- Protein
- E3
- Ubiquitination
- Domain
- Chromosome
- Proteins
- Function
- Location
ubiquitin ligase
- Ubiquitin
- E3
- Function
- Location
- Activity
- Bp
- Chr
- Chromosome
- Expression
- Regulation
- Nedd4l
- Nedd4
gene
- Human
- Chromosome
- Location
- Nedd4l
- Protein
- Ligase
- Bp
- Chr
- Ubiquitin
- Mouse
- Nedd4
- Nedd4-2
epithelial sodium channel
- Sodium
- Enac
- Function
- Location
- Shown
- Ubiquitination
- Activity
- Band
- Binding
- Domain
- Kidney
- Ligase
gene duplication
- Human
- Chromosome
- Location
- Nedd4l
- Protein
- Ligase
- Bp
- Chr
- Ubiquitin
- Mouse
- Nedd4
- Nedd4-2
expression
- Activity
- Regulation
- Mouse
- Function
- Location
- Ligase
- Lung
- Sodium
- Nedd4-2
- Bp
- Chr
- Chromosome
enzyme
- Ligase
- Ubiquitin
- E3
- Expressed
- Nedd4
- Family
- Function
- Gene
- Location
- Nedd4l
- Activity
- Specific

Connections between topic areas Semantic bridges

For NEDD4L, one of the stronger structural bridges in this analysis connects NEDD4L with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3

NEDD4L — Overview · splits 8 ⟂ 14

NEDD4L — Interactions · splits 19 ⟂ 3

Map overview Semantic statistics

NEDD4L

Nodes22

Edges21

Triples148

Avg. degree1.91

Density0.090909

Components1

Source & methodology

TTTA analyzes the structure around NEDD4L to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Overview, Interactions & Expression, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — NEDD4L · EN edition · Analysis: TopicsToTalkAbout