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Mercaptopurine: History, Side effects & Mechanisms of action
Mercaptopurine (6-MP), sold under the brand name Purinethol among others, is a medication used for cancer and autoimmune diseases. Specifically it is used to treat acute lymphocytic leukemia (ALL), acute promyelocytic leukemia (APL), Crohn's disease, and ulcerative colitis. For acute lymphocytic leukemia it is generally used with methotrexate. It is…
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Mercaptopurine topic overview
The analysis highlights History, Side effects and Mechanisms of action as prominent areas in the source structure around Mercaptopurine.
Related topics
68
Source areas
5
Connected nodes
73
Extracted relationships
104
Concept neighborhoods
23
Bridge connections
73
What this topic covers Research coverage
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Side effects · 25 topics
Mechanisms of action · 18 topics
Overview · 15 topics
History · 8 topics
Drug interactions · 2 topics
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
Key facts & relationships
High-confidence facts extracted from structured source data. Use them as anchors for further research.
3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
L01BB02 (WHO)
Bioavailability
5 to 37%
CAS Number
50-44-2 Y
ChEBI
CHEBI:50667 Y
Explore all related topics Closing gaps
A structured outline of related entities, concepts and subtopics. Open any item to build a new map centered on it.
Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
How Mercaptopurine connects Entity context
Entity context groups extracted connections by relationship type. Counts show recurrence in the analyzed source; the examples are research signals, not claims about importance.
The extracted context around Mercaptopurine shows recurring relationship patterns in the source. For example, Mercaptopurine → AMP, Animal, Both TIMP, DNA, Experiments, HGPRT, However, IMP, In, It, MP, MTIMP, Official, RNA, SAMP, Some, Specifically, TG, TGMP, TIMP Another extracted example is Mercaptopurine → AZA, Cancers, CESAME, Colitis Organisation, Davis, ECCO, En France, FDA, France, However, It, Maladies, Surrisque Associe, The European Crohn's, There, This, Those, US FDA. Use these groups to spot repeated connection types before inspecting the individual relationships.
Mercaptopurine
Top relations
related to Mechanisms of action· 21
Mercaptopurine → AMP, Animal, Both TIMP, DNA, Experiments, HGPRT, However, IMP, In, It, MP, MTIMP, Official, RNA, SAMP, Some, Specifically, TG, TGMP, TIMP
related to Precautions· 18
Mercaptopurine → AZA, Cancers, CESAME, Colitis Organisation, Davis, ECCO, En France, FDA, France, However, It, Maladies, Surrisque Associe, The European Crohn's, There, This, Those, US FDA
related to Further reading· 13
Mercaptopurine → Biotechnology Information, Bookshelf ID, Dean, In Pratt VM, McLeod HL, Medical Genetics Summaries, Mercaptopurine Therapy, National Center, NBK100660, NCBI, PMID, Rubinstein WS, TPMT Genotype
related to Pharmacogenetics· 9
Mercaptopurine → Certain, However, In, S-methyltransferase, Testing, TGN, The, The FDA-approved, TPMT
Mercaptopurine → antimetabolite antineoplastic, purine antimetabolite or purine antagonist and as such inhibits DNA synthesis by inhibiting the production of the purine containing nucleotides
3D model (JSmol)· 1
Mercaptopurine → Interactive image
AHFS/Drugs.com· 1
Mercaptopurine → Monograph
Important terminology
Frequent words and multi-word phrases across the lead, headings, infobox and body. Useful for terminology coverage.
Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.
Relationships are represented as Subject → Predicate → Object triples. Confidence describes extraction strength, not the real-world importance of a relationship; lower-confidence rows may be contextual rather than explicit.
TTTA extracted 104 structured relationships around Mercaptopurine. Examples in this analysis include Mercaptopurine → 3D model (JSmol) → Interactive image and Mercaptopurine → AHFS/Drugs.com → Monograph. The table shows each extracted connection, where it came from and its confidence.
Subject
Predicate
Object
Confidence
Src
Mercaptopurine
3D model (JSmol)
Interactive image
1.00
infobox
Mercaptopurine
AHFS/Drugs.com
Monograph
1.00
infobox
Mercaptopurine
ATC code
L01BB02 (WHO)
1.00
infobox
Mercaptopurine
Bioavailability
5 to 37%
1.00
infobox
Mercaptopurine
CAS Number
50-44-2 Y
1.00
infobox
Mercaptopurine
ChEBI
CHEBI:50667 Y
1.00
infobox
Mercaptopurine
ChEMBL
ChEMBL1425 Y
1.00
infobox
Mercaptopurine
ChemSpider
580869 Y
1.00
infobox
Mercaptopurine
CompTox Dashboard (EPA)
DTXSID0020810
1.00
infobox
Mercaptopurine
DrugBank
DB01033 Y
1.00
infobox
Mercaptopurine
ECHA InfoCard
100.000.035
1.00
infobox
Mercaptopurine
Elimination half-life
60 to 120 min., longer for its active metabolites
1.00
infobox
Mercaptopurine
Excretion
kidney
1.00
infobox
Mercaptopurine
Formula
C5H4N4S
1.00
infobox
Mercaptopurine
IUPHAR/BPS
7226
1.00
infobox
Mercaptopurine
KEGG
D04931 Y
1.00
infobox
Mercaptopurine
Legal status
AU: S4 (Prescription only)
1.00
infobox
Mercaptopurine
Legal status
EU: Rx-only
1.00
infobox
Mercaptopurine
Legal status
In general: ℞ (Prescription only)
1.00
infobox
Mercaptopurine
License data
US DailyMed: Mercaptopurine
1.00
infobox
Mercaptopurine
MedlinePlus
a682653
1.00
infobox
Mercaptopurine
Metabolism
xanthine oxidase
1.00
infobox
Mercaptopurine
Molar mass
152.18 g·mol−1
1.00
infobox
Mercaptopurine
Other names
6-mercaptopurine (6-MP)
1.00
infobox
Mercaptopurine
PubChem CID
667490
1.00
infobox
Mercaptopurine
Routes of administration
By mouth
1.00
infobox
Mercaptopurine
Trade names
Purinethol, Purixan, others
1.00
infobox
Mercaptopurine
UNII
PKK6MUZ20G
1.00
infobox
Mercaptopurine
causes
changes to chromosomes in animals and humans
0.90
text
Mercaptopurine
is a
antimetabolite antineoplastic
0.90
text
No triples extracted yet.
Related concept clusters Concept neighborhoods
Concept neighborhoods group terms that sit near one another in the extracted graph. They are useful for discovering adjacent language and context, but proximity does not by itself imply a factual relationship.
The concept neighborhoods around Mercaptopurine bring nearby vocabulary together. In this analysis, examples include May, Dna and Tpmt. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
Mercaptopurine
May
Dna
Tpmt
Cells
Activity
Risk
Synthesis
Enzyme
Antimetabolite
Purinethol
Blood
Drugs
mercaptopurine
May
Dna
Tpmt
Cells
Activity
Risk
Synthesis
Enzyme
Antimetabolite
Purinethol
Blood
Drugs
drug interactions
Activity
Effects
People
Tpmt
Lymphocytic
Medical
Pregnancy
Purinethol
Blood
Cells
Dose
Drugs
thiopurine s-methyltransferase (tpmt)
Activity
Genetic
People
Mercaptopurine
Metabolites
Thiopurine
Tpmt
Drug
Risk
Enzyme
Blood
Cells
suppress the production of blood cells
People
Cells
Purinethol
Dose
Genetic
However
Several
Mercaptopurine
Taking
Activity
Dna
Drug
white blood cells
People
Cells
Purinethol
Dose
Genetic
However
Several
Mercaptopurine
Taking
Activity
Dna
Drug
red blood cells
People
Cells
Purinethol
Dose
Genetic
However
Several
Mercaptopurine
Taking
Activity
Dna
Drug
genetic variations
Thiopurine
Tpmt
Activity
Risk
Blood
Cells
Dose
However
Metabolites
Side
Drug
People
Connections between topic areas Semantic bridges
Semantic bridges connect parts of the graph that would otherwise be more separate. A bridge is a structural signal in this analysis, not a claim that the two topic areas are equivalent.
For Mercaptopurine, one of the stronger structural bridges in this analysis connects Mercaptopurine with Side effects. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
Number of nodes, edges, triples, density and central hubs. Use it to gauge the size and connectivity of the map.
Mercaptopurine
Nodes74
Edges73
Triples104
Avg. degree1.97
Density0.027027
Components1
Source & methodology
TTTA analyzes the structure around Mercaptopurine to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History, Side effects & Mechanisms of action, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
