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Mercaptopurine

Mercaptopurine (6-MP), sold under the brand name Purinethol among others, is a medication used for cancer and autoimmune diseases. Specifically it is used to treat acute lymphocytic leukemia (ALL), acute promyelocytic leukemia (APL), Crohn's disease, and ulcerative colitis. For acute lymphocytic leukemia it is generally used with methotrexate. It is…

History, Side effects & Mechanisms of action

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3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
L01BB02 (WHO)
Bioavailability
5 to 37%
CAS Number
50-44-2 Y
ChEBI
CHEBI:50667 Y

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Overview

Side effects

Drug interactions

Mechanisms of action

History

Advanced semantic analysis

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Map overview Semantic statistics

Mercaptopurine

Nodes74
Edges73
Triples104
Avg. degree1.97
Density0.027027
Components1

How this topic connects Entity context

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Mercaptopurine

Top relations

related to Mechanisms of action · 21
Mercaptopurine → AMP, Animal, Both TIMP, DNA, Experiments, HGPRT, However, IMP, In, It, MP, MTIMP, Official, RNA, SAMP, Some, Specifically, TG, TGMP, TIMP
related to Precautions · 18
Mercaptopurine → AZA, Cancers, CESAME, Colitis Organisation, Davis, ECCO, En France, FDA, France, However, It, Maladies, Surrisque Associe, The European Crohn's, There, This, Those, US FDA
related to Further reading · 13
Mercaptopurine → Biotechnology Information, Bookshelf ID, Dean, In Pratt VM, McLeod HL, Medical Genetics Summaries, Mercaptopurine Therapy, National Center, NBK100660, NCBI, PMID, Rubinstein WS, TPMT Genotype
related to Pharmacogenetics · 9
Mercaptopurine → Certain, However, In, S-methyltransferase, Testing, TGN, The, The FDA-approved, TPMT
has effect · 7
Mercaptopurine → Clinically, LC-MS, Other, Serious, Some, Symptoms, Treatment
related to Drug interactions · 5
Mercaptopurine → Allopurinol, MP, Several, The, Those
Legal status · 3
Mercaptopurine → AU: S4 (Prescription only), EU: Rx-only, In general: ℞ (Prescription only)
is a · 2
Mercaptopurine → antimetabolite antineoplastic, purine antimetabolite or purine antagonist and as such inhibits DNA synthesis by inhibiting the production of the purine containing nucleotides
3D model (JSmol) · 1
Mercaptopurine → Interactive image
AHFS/Drugs.com · 1
Mercaptopurine → Monograph

Important terminology Word statistics

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Important terminology

effects tpmt may used side 6-mp enzyme include risk dna purine thiopurine people synthesis drug cancer activity timp leukemia allopurinol

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Mercaptopurine3D model (JSmol)Interactive image1.00infobox
MercaptopurineAHFS/Drugs.comMonograph1.00infobox
MercaptopurineATC codeL01BB02 (WHO)1.00infobox
MercaptopurineBioavailability5 to 37%1.00infobox
MercaptopurineCAS Number50-44-2 Y1.00infobox
MercaptopurineChEBICHEBI:50667 Y1.00infobox
MercaptopurineChEMBLChEMBL1425 Y1.00infobox
MercaptopurineChemSpider580869 Y1.00infobox
MercaptopurineCompTox Dashboard (EPA)DTXSID00208101.00infobox
MercaptopurineDrugBankDB01033 Y1.00infobox
MercaptopurineECHA InfoCard100.000.0351.00infobox
MercaptopurineElimination half-life60 to 120 min., longer for its active metabolites1.00infobox
MercaptopurineExcretionkidney1.00infobox
MercaptopurineFormulaC5H4N4S1.00infobox
MercaptopurineIUPHAR/BPS72261.00infobox
MercaptopurineKEGGD04931 Y1.00infobox
MercaptopurineLegal statusAU: S4 (Prescription only)1.00infobox
MercaptopurineLegal statusEU: Rx-only1.00infobox
MercaptopurineLegal statusIn general: ℞ (Prescription only)1.00infobox
MercaptopurineLicense dataUS DailyMed: Mercaptopurine1.00infobox
MercaptopurineMedlinePlusa6826531.00infobox
MercaptopurineMetabolismxanthine oxidase1.00infobox
MercaptopurineMolar mass152.18 g·mol−11.00infobox
MercaptopurineOther names6-mercaptopurine (6-MP)1.00infobox
MercaptopurinePubChem CID6674901.00infobox
MercaptopurineRoutes of administrationBy mouth1.00infobox
MercaptopurineTrade namesPurinethol, Purixan, others1.00infobox
MercaptopurineUNIIPKK6MUZ20G1.00infobox
Mercaptopurinecauseschanges to chromosomes in animals and humans0.90text
Mercaptopurineis aantimetabolite antineoplastic0.90text

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