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Spironolactone

Spironolactone, sold under the brand name Aldactone among others, is classed as a diuretic medication. It can be used to treat fluid build-up due to liver disease or kidney disease. It is also used to reduce risk of disease progression, hospitalization, and death due to some types of heart failure. Other uses include acne and excessive hair growth in…

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3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
C03DA01 (WHO)
Bioavailability
60–90%
CAS Number
52-01-7 Y
ChEBI
CHEBI:9241 Y

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Overview

Medical uses

Contraindications

Side effects

Overdose

Interactions

Pharmacology

Chemistry

History

Society and culture

Research

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Map overview Semantic statistics

Spironolactone

Nodes386
Edges385
Triples345
Avg. degree1.99
Density0.005181
Components1

How this topic connects Entity context

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Spironolactone

Top relations

related to Brand names · 43
Spironolactone → Aldactacine, Aldactazide, Aldactazine, Aldactide, Aldactone, Aldactone-A, Berlactone, Cardalis, CaroSpir, Dytor Plus, Espironolactona, Espironolactona Genfar, Fruselac, Lasilacton, Lasilactone, Metolactone, Novo-Spiroton, Other, Prilactone, Sali-Aldopur
related to Generic names · 19
Spironolactone → BANTooltip British Approved Name, DCFTooltip Dénomination Commune Française, DCITTooltip Denominazione Comune Italiana, French, German, INNTooltip International Nonproprietary Name, Italian, Its, JANTooltip Japanese Accepted Name, Latin, Name, NSC-150339, Portuguese, SC-9420, Spanish, Spironolacton, The English, USANTooltip United States Adopted, USPTooltip United States Pharmacopeia
related to High potassium levels · 19
Spironolactone → ACE, Although, An, At, However, II, July, Notably, Occasional, Of, Other, RALES, Randomized Aldactone Evaluation Study, Rarely, Scotland, Side, The, These, This
related to Skin and hair conditions · 13
Spironolactone → Androgens, Because, Conversely, DHT, II, In, Moreover, Oftentimes, Ongoing, Positive, Response, There, Though
related to Chemistry · 10
Spironolactone → AR, C17α, C17β, C7α, In, It, SC-5233, SC-8365, The C7α, These
related to Interactions · 10
Spironolactone → CYP3A4, Doctors, However, In, Physicians, Recent, The, Therefore, UDP-glucuronosyltransferases, UGT2B7
has effect · 9
Spironolactone → Also, Aside, At, Because, Hyperkalemia, In, One, Other, The
related to Breast changes · 9
Spironolactone → As, At, Breast, Conversely, In, RALES, Some, The, This
related to Menstrual disturbances · 9
Spironolactone → An, CYP17A1, For, Indeed, It, Most, Regardless, The, They
related to Overdose · 9
Spironolactone → Hyperkalemia, In, Its, LD50, No, Symptoms, The, These, Treatment

Important terminology Word statistics

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Important terminology

effects women treatment acne also used levels hyperkalemia high side found due may potassium doses medication breast antiandrogen antiandrogenic well

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Spironolactone3D model (JSmol)Interactive image1.00infobox
SpironolactoneAHFS/Drugs.comMonograph1.00infobox
SpironolactoneATC codeC03DA01 (WHO)1.00infobox
SpironolactoneBioavailability60–90%1.00infobox
SpironolactoneCAS Number52-01-7 Y1.00infobox
SpironolactoneChEBICHEBI:9241 Y1.00infobox
SpironolactoneChEMBLChEMBL1393 Y1.00infobox
SpironolactoneChemSpider5628 Y1.00infobox
SpironolactoneCompTox Dashboard (EPA)DTXSID60341861.00infobox
SpironolactoneDrug classAntimineralocorticoid; Steroidal antiandrogen1.00infobox
SpironolactoneDrugBankDB00421 Y1.00infobox
SpironolactoneECHA InfoCard100.000.1221.00infobox
SpironolactoneElimination half-lifeSpironolactone: 1.4 hrs 7α-TMSTooltip 7α-thiomethylspironolactone: 13.8 hours 6β-OH-7α-TMSTooltip 6β-hydroxy-7α-thiomethylspironolactone: 15.0 hrs Canrenone: 16.5 hours1.00infobox
SpironolactoneExcretionUrine, bile1.00infobox
SpironolactoneFormulaC24H32O4S1.00infobox
SpironolactoneIUPHAR/BPS28751.00infobox
SpironolactoneKEGGD00443 Y1.00infobox
SpironolactoneLegal statusUK: POM (Prescription only)1.00infobox
SpironolactoneLegal statusUS: ℞-only1.00infobox
SpironolactoneLegal statusEU: Rx-only1.00infobox
SpironolactoneLicense dataUS DailyMed: Spironolactone1.00infobox
SpironolactoneMedlinePlusa6826271.00infobox
SpironolactoneMelting point134 to 135 °C (273 to 275 °F)1.00infobox
SpironolactoneMetabolismLiver, others: • Deacetylation via CESTooltip carboxylesterase • S-Oxygenation via FOMTooltip flavin-containing monooxygenase • S-Methylation via TMTTooltip thiol S-methyltransf…1.00infobox
SpironolactoneMetabolites7α-TSTooltip 7α-Thiospironolactone, 7α-TMSTooltip 7α-thiomethylspironolactone, 6β-OH-7α-TMSTooltip 6β-hydroxy-7α-thiomethylspironolactone, canrenone, others (All three active)1.00infobox
SpironolactoneMolar mass416.58 g·mol−11.00infobox
SpironolactoneOther namesSC-9420; NSC-150339; 7α-Acetylthiospirolactone; 7α-Acetylthio-17α-hydroxy-3-oxopregn-4-ene-21-carboxylic acid γ-lactone1.00infobox
SpironolactonePregnancy categoryAU: B31.00infobox
SpironolactonePronunciation/ˌspaɪroʊnoʊˈlæktoʊn/ SPY-roh-noh-LAK-tone, /ˌspɪəroʊnoʊˈlæktoʊn/ ⓘ SPEER-oh-noh-LAK-tone1.00infobox
SpironolactoneProtein bindingSpironolactone: 88% (to albumin and AGPTooltip alpha-1-acid glycoprotein) Canrenone: 99.2% (to albumin)1.00infobox

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