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Spironolactone, sold under the brand name Aldactone among others, is classed as a diuretic medication. It can be used to treat fluid build-up due to liver disease or kidney disease. It is also used to reduce risk of disease progression, hospitalization, and death due to some types of heart failure. Other uses include acne and excessive hair growth in…
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| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| Spironolactone | 3D model (JSmol) | Interactive image | 1.00 | infobox |
| Spironolactone | AHFS/Drugs.com | Monograph | 1.00 | infobox |
| Spironolactone | ATC code | C03DA01 (WHO) | 1.00 | infobox |
| Spironolactone | Bioavailability | 60–90% | 1.00 | infobox |
| Spironolactone | CAS Number | 52-01-7 Y | 1.00 | infobox |
| Spironolactone | ChEBI | CHEBI:9241 Y | 1.00 | infobox |
| Spironolactone | ChEMBL | ChEMBL1393 Y | 1.00 | infobox |
| Spironolactone | ChemSpider | 5628 Y | 1.00 | infobox |
| Spironolactone | CompTox Dashboard (EPA) | DTXSID6034186 | 1.00 | infobox |
| Spironolactone | Drug class | Antimineralocorticoid; Steroidal antiandrogen | 1.00 | infobox |
| Spironolactone | DrugBank | DB00421 Y | 1.00 | infobox |
| Spironolactone | ECHA InfoCard | 100.000.122 | 1.00 | infobox |
| Spironolactone | Elimination half-life | Spironolactone: 1.4 hrs 7α-TMSTooltip 7α-thiomethylspironolactone: 13.8 hours 6β-OH-7α-TMSTooltip 6β-hydroxy-7α-thiomethylspironolactone: 15.0 hrs Canrenone: 16.5 hours | 1.00 | infobox |
| Spironolactone | Excretion | Urine, bile | 1.00 | infobox |
| Spironolactone | Formula | C24H32O4S | 1.00 | infobox |
| Spironolactone | IUPHAR/BPS | 2875 | 1.00 | infobox |
| Spironolactone | KEGG | D00443 Y | 1.00 | infobox |
| Spironolactone | Legal status | UK: POM (Prescription only) | 1.00 | infobox |
| Spironolactone | Legal status | US: ℞-only | 1.00 | infobox |
| Spironolactone | Legal status | EU: Rx-only | 1.00 | infobox |
| Spironolactone | License data | US DailyMed: Spironolactone | 1.00 | infobox |
| Spironolactone | MedlinePlus | a682627 | 1.00 | infobox |
| Spironolactone | Melting point | 134 to 135 °C (273 to 275 °F) | 1.00 | infobox |
| Spironolactone | Metabolism | Liver, others: • Deacetylation via CESTooltip carboxylesterase • S-Oxygenation via FOMTooltip flavin-containing monooxygenase • S-Methylation via TMTTooltip thiol S-methyltransf… | 1.00 | infobox |
| Spironolactone | Metabolites | 7α-TSTooltip 7α-Thiospironolactone, 7α-TMSTooltip 7α-thiomethylspironolactone, 6β-OH-7α-TMSTooltip 6β-hydroxy-7α-thiomethylspironolactone, canrenone, others (All three active) | 1.00 | infobox |
| Spironolactone | Molar mass | 416.58 g·mol−1 | 1.00 | infobox |
| Spironolactone | Other names | SC-9420; NSC-150339; 7α-Acetylthiospirolactone; 7α-Acetylthio-17α-hydroxy-3-oxopregn-4-ene-21-carboxylic acid γ-lactone | 1.00 | infobox |
| Spironolactone | Pregnancy category | AU: B3 | 1.00 | infobox |
| Spironolactone | Pronunciation | /ˌspaɪroʊnoʊˈlæktoʊn/ SPY-roh-noh-LAK-tone, /ˌspɪəroʊnoʊˈlæktoʊn/ ⓘ SPEER-oh-noh-LAK-tone | 1.00 | infobox |
| Spironolactone | Protein binding | Spironolactone: 88% (to albumin and AGPTooltip alpha-1-acid glycoprotein) Canrenone: 99.2% (to albumin) | 1.00 | infobox |
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