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Alpha-actinin-2

Alpha-actinin-2 is a protein which in humans is encoded by the ACTN2 gene. This gene encodes an alpha-actinin isoform that is expressed in both skeletal and cardiac muscles and functions to anchor myofibrillar actin thin filaments and titin to Z-discs.

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Aliases
ACTN2, CMD1AA, CMH23, actinin alpha 2, MYOCOZ, MPD6
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1H8B, 1HCI, 1QUU, 4D1E, 5A37, 5A36, 5A38, 5A4B
Band
1q43 · 13 A1|13 4.54 cM
Bgee
Skeletal muscle tissue of rectus abdominis · Skeletal muscle tissue of biceps brachii · muscle of thigh · apex of heart · glutes
BioGPS
More reference expression data
Chr.
Chromosome 1 (human) · Chromosome 13 (mouse)

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Alpha-actinin-2

Nodes35
Edges34
Triples157
Avg. degree1.94
Density0.057143
Components1

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Alpha-actinin-2

Top relations

Gene ontology · 63
Alpha-actinin-2 → actin binding, actin filament, actin filament binding, actin filament uncapping, calcium ion binding, cardiac muscle cell development, cell adhesion, cortical actin cytoskeleton, cytoplasm, cytoskeletal protein binding, cytoskeleton, cytosol, dendritic spine, extracellular exosome, extracellular region, FATZ binding, filopodium, focal adhesion, focal adhesion assembly, glutamatergic synapse
related to Structure · 24
Alpha-actinin-2 → ACTN3, ADAM12, Alpha, Alpha-actinin, C-terminal EF, DISC1, DLG1, Each, FATZ, GRIN2B, KCNA5, LDB3, MYOT, MYOZ1, MYPN, N-terminal, NMDAR, PDLIM3, PKN, Skeletal
Bgee · 19
Alpha-actinin-2 → ankle, apex of heart, cardiac muscles, deltoid muscle, digastric muscle, extraocular muscle, gastrocnemius muscle, glutes, muscle of thigh, myocardium of left ventricle, myocardium of ventricle, right ventricle, Skeletal muscle tissue of biceps brachii, Skeletal muscle tissue of rectus abdominis, soleus muscle, sternocleidomastoid muscle, temporal muscle, tibialis anterior muscle, triceps brachii muscle
RNA expression pattern · 19
Alpha-actinin-2 → ankle, apex of heart, cardiac muscles, deltoid muscle, digastric muscle, extraocular muscle, gastrocnemius muscle, glutes, muscle of thigh, myocardium of left ventricle, myocardium of ventricle, right ventricle, Skeletal muscle tissue of biceps brachii, Skeletal muscle tissue of rectus abdominis, soleus muscle, sternocleidomastoid muscle, temporal muscle, tibialis anterior muscle, triceps brachii muscle
related to Function · 5
Alpha-actinin-2 → Hampton, It, Kv1, The, Z-discs
related to Clinical significance · 3
Alpha-actinin-2 → ACTN2, Mutations, The
Band · 2
Alpha-actinin-2 → 13 A1|13 4.54 cM, 1q43
Chr. · 2
Alpha-actinin-2 → Chromosome 1 (human), Chromosome 13 (mouse)
End · 2
Alpha-actinin-2 → 12,355,641 bp, 236,764,631 bp
Aliases · 1
Alpha-actinin-2 → ACTN2, CMD1AA, CMH23, actinin alpha 2, MYOCOZ, MPD6

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Important terminology

gene actn2 human bp chr band chromosome cardiac actin location titin z-discs protein skeletal function alpha-actinin functions alpha mouse expressed

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Alpha-actinin-2AliasesACTN2, CMD1AA, CMH23, actinin alpha 2, MYOCOZ, MPD61.00infobox
Alpha-actinin-2Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1H8B, 1HCI, 1QUU, 4D1E, 5A37, 5A36, 5A38, 5A4B1.00infobox
Alpha-actinin-2Band1q431.00infobox
Alpha-actinin-2Band13 A1|13 4.54 cM1.00infobox
Alpha-actinin-2BgeeSkeletal muscle tissue of rectus abdominis1.00infobox
Alpha-actinin-2BgeeSkeletal muscle tissue of biceps brachii1.00infobox
Alpha-actinin-2Bgeemuscle of thigh1.00infobox
Alpha-actinin-2Bgeeapex of heart1.00infobox
Alpha-actinin-2Bgeeglutes1.00infobox
Alpha-actinin-2Bgeegastrocnemius muscle1.00infobox
Alpha-actinin-2Bgeeright ventricle1.00infobox
Alpha-actinin-2Bgeetriceps brachii muscle1.00infobox
Alpha-actinin-2Bgeemyocardium of left ventricle1.00infobox
Alpha-actinin-2Bgeedeltoid muscle1.00infobox
Alpha-actinin-2Bgeesoleus muscle1.00infobox
Alpha-actinin-2Bgeeankle1.00infobox
Alpha-actinin-2Bgeemyocardium of ventricle1.00infobox
Alpha-actinin-2Bgeeextraocular muscle1.00infobox
Alpha-actinin-2Bgeedigastric muscle1.00infobox
Alpha-actinin-2Bgeecardiac muscles1.00infobox
Alpha-actinin-2Bgeetemporal muscle1.00infobox
Alpha-actinin-2Bgeetibialis anterior muscle1.00infobox
Alpha-actinin-2Bgeesternocleidomastoid muscle1.00infobox
Alpha-actinin-2BioGPSMore reference expression data1.00infobox
Alpha-actinin-2Chr.Chromosome 1 (human)1.00infobox
Alpha-actinin-2Chr.Chromosome 13 (mouse)1.00infobox
Alpha-actinin-2DatabasesNCBI: entry; OMA: entry1.00infobox
Alpha-actinin-2End236,764,631 bp1.00infobox
Alpha-actinin-2End12,355,641 bp1.00infobox
Alpha-actinin-2EnsemblENSG000000775221.00infobox

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