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MYOT

Myotilin is a protein that in humans is encoded by the MYOT gene. Myotilin (myofibrillar titin-like protein) also known as TTID (TiTin Immunoglobulin Domain) is a muscle protein that is found within the Z-disc of sarcomeres.

Structure, Clinical significance & Function

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Structure

11 related topics

Clinical significance

6 related topics

Function

2 related topics

Overview

3 related topics

Key facts & relationships

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Aliases
MYOT, LGMD1, LGMD1A, MFM3, TTID, TTOD, myotilin
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2KDG, 2KKQ
Band
5q31.2 · 18|18 B3
Bgee
muscle of thigh · gastrocnemius muscle · Skeletal muscle tissue of rectus abdominis · Skeletal muscle tissue of biceps brachii · vastus lateralis muscle
BioGPS
More reference expression data
Chr.
Chromosome 5 (human) · Chromosome 18 (mouse)

Topics to explore

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Overview

Structure

Function

Clinical significance

Advanced semantic analysis

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Map overview Semantic statistics

MYOT

Nodes27
Edges26
Triples159
Avg. degree1.93
Density0.074074
Components1

How this topic connects Entity context

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MYOT

Top relations

related to External links · 36
MYOT → Apweiler, Choi JH, Circ Res, CIRCRESAHA, Deng, Duan, Fang, Ge, GeneReviews/NIH/NCBI/UW, Hermjakob, Integration, Jimenez RC, Kim AK, Kim CS, Lam MP, Li, Liem, Lu HJ, Meyer, Myofibrillar MyopathyOverview
related to Clinical significance · 19
MYOT → Arg405Lys, Distal Myopath, It, LGMD1A, Limb-Girdle Muscular Dystrophy, MFM, Myofibrillar Myopathy, Myotilin, Ser55Ile, Ser55Phe, Ser60Cys, Ser60Phe, Ser95Ile, Spheroid Body Myopathy, Surprisingly, The, Thr57Ile, YFP-fusion, Z-discs
Bgee · 18
MYOT → Achilles tendon, ankle, body of tongue, buccal mucosa cell, deltoid muscle, digastric muscle, gastrocnemius muscle, intercostal muscle, muscle of thigh, Skeletal muscle tissue of biceps brachii, Skeletal muscle tissue of rectus abdominis, soleus muscle, sternocleidomastoid muscle, temporal muscle, testicle, thoracic diaphragm, triceps brachii muscle, vastus lateralis muscle
Gene ontology · 18
MYOT → actin binding, actin cytoskeleton, alpha-actinin binding, axon, axon guidance, axon guidance receptor activity, cytoplasm, cytoskeleton, homophilic cell adhesion via plasma membrane adhesion molecules, membrane, muscle contraction, plasma membrane, protein binding, sarcolemma, soma, structural constituent of muscle, synapse organization, Z discdkac
RNA expression pattern · 18
MYOT → Achilles tendon, ankle, body of tongue, buccal mucosa cell, deltoid muscle, digastric muscle, gastrocnemius muscle, intercostal muscle, muscle of thigh, Skeletal muscle tissue of biceps brachii, Skeletal muscle tissue of rectus abdominis, soleus muscle, sternocleidomastoid muscle, temporal muscle, testicle, thoracic diaphragm, triceps brachii muscle, vastus lateralis muscle
related to Structure · 18
MYOT → By, C-terminal, FATZ-1, FATZ-2, Filamin, Ig, Ig-like, In, Myotilin, N-terminal, Several, The C-terminal, The I-type Ig-like, Z-band, Z-disc, Z-disc Ig, Z-discs, ZASP
related to Function · 9
MYOT → Ectopic, F-actin, In, It, Myotilin, On, Targeted, Z-disc, Z-discs
Band · 2
MYOT → 18|18 B3, 5q31.2
Chr. · 2
MYOT → Chromosome 18 (mouse), Chromosome 5 (human)
End · 2
MYOT → 137,887,851 bp, 44,488,791 bp

Important terminology Word statistics

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Important terminology

myotilin bp human protein alpha-actinin gene muscle titin chr band actin z-disc chromosome sarcomeres binding location function myofibrillar within z-discs

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
MYOTAliasesMYOT, LGMD1, LGMD1A, MFM3, TTID, TTOD, myotilin1.00infobox
MYOTAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2KDG, 2KKQ1.00infobox
MYOTBand5q31.21.00infobox
MYOTBand18|18 B31.00infobox
MYOTBgeemuscle of thigh1.00infobox
MYOTBgeegastrocnemius muscle1.00infobox
MYOTBgeeSkeletal muscle tissue of rectus abdominis1.00infobox
MYOTBgeeSkeletal muscle tissue of biceps brachii1.00infobox
MYOTBgeevastus lateralis muscle1.00infobox
MYOTBgeebody of tongue1.00infobox
MYOTBgeebuccal mucosa cell1.00infobox
MYOTBgeeAchilles tendon1.00infobox
MYOTBgeedeltoid muscle1.00infobox
MYOTBgeetesticle1.00infobox
MYOTBgeedigastric muscle1.00infobox
MYOTBgeetemporal muscle1.00infobox
MYOTBgeesoleus muscle1.00infobox
MYOTBgeetriceps brachii muscle1.00infobox
MYOTBgeesternocleidomastoid muscle1.00infobox
MYOTBgeeankle1.00infobox
MYOTBgeeintercostal muscle1.00infobox
MYOTBgeethoracic diaphragm1.00infobox
MYOTBioGPSMore reference expression data1.00infobox
MYOTChr.Chromosome 5 (human)1.00infobox
MYOTChr.Chromosome 18 (mouse)1.00infobox
MYOTDatabasesNCBI: entry; OMA: entry1.00infobox
MYOTEnd137,887,851 bp1.00infobox
MYOTEnd44,488,791 bp1.00infobox
MYOTEnsemblENSG000001207291.00infobox
MYOTEntrez94991.00infobox

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