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Alpha-actinin-3

Alpha-actinin-3, also known as alpha-actinin skeletal muscle isoform 3 or F-actin cross-linking protein, is a protein that in humans is encoded by the ACTN3 gene (named sprinter gene, speed gene or athlete gene) located on chromosome 11. All people have two copies (alleles) of this gene.

Standards, Alleles & Fast versus slow twitch muscle fibers

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Alleles

AlleleHomozygousGenotypeExonArginine base
9 related topics

Fast versus slow twitch muscle fibers

Skeletal muscleMuscle contraction
2 related topics

Interactions

Interact
1 related topics

Overview

ProteinGeneChromosomeActinZ-disc
5 related topics

Key facts & relationships

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Aliases
ACTN3, actinin alpha 3 (gene/pseudogene), ACTN3D, actinin alpha 3
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1TJT, 1WKU, 3LUE
Band
11q13.2 · 19 A|19 4.12 cM
Bgee
Skeletal muscle tissue of rectus abdominis · Skeletal muscle tissue of biceps brachii · thoracic diaphragm · vastus lateralis muscle · muscle of thigh
BioGPS
More reference expression data
Chr.
Chromosome 11 (human) · Chromosome 19 (mouse)

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Overview

Fast versus slow twitch muscle fibers

Alleles

Interactions

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Map overview Semantic statistics

Alpha-actinin-3

Nodes22
Edges21
Triples96
Avg. degree1.91
Density0.090909
Components1

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Alpha-actinin-3

Top relations

Gene ontology · 28
Alpha-actinin-3 → actin binding, actin filament, calcium ion binding, cytosol, extracellular exosome, focal adhesion, focal adhesion assembly, integrin binding, intracellular anatomical structure, metal ion binding, muscle filament sliding, negative regulation of calcineurin-NFAT signaling cascade, negative regulation of cold-induced thermogenesis, negative regulation of glycolytic process, negative regulation of oxidative phosphorylation, positive regulation of glucose catabolic process to lactate via pyruvate, positive regulation of skeletal muscle tissue growth, protein binding, protein homodimerization activity, pseudopodium
Bgee · 16
Alpha-actinin-3 → ankle, deltoid muscle, extensor digitorum longus muscle, gastrocnemius muscle, glutes, medial head of gastrocnemius muscle, muscle of thigh, plantaris muscle, Skeletal muscle tissue of biceps brachii, Skeletal muscle tissue of rectus abdominis, sternocleidomastoid muscle, temporal muscle, thoracic diaphragm, tibialis anterior muscle, triceps brachii muscle, vastus lateralis muscle
RNA expression pattern · 16
Alpha-actinin-3 → ankle, deltoid muscle, extensor digitorum longus muscle, gastrocnemius muscle, glutes, medial head of gastrocnemius muscle, muscle of thigh, plantaris muscle, Skeletal muscle tissue of biceps brachii, Skeletal muscle tissue of rectus abdominis, sternocleidomastoid muscle, temporal muscle, thoracic diaphragm, tibialis anterior muscle, triceps brachii muscle, vastus lateralis muscle
related to Fast versus slow twitch muscle fibers · 7
Alpha-actinin-3 → Fast, However, II, Skeletal, Slow, The, There
related to Alleles · 6
Alpha-actinin-3 → ACTN3, An, Homozygous, It, Over, The
Band · 2
Alpha-actinin-3 → 11q13.2, 19 A|19 4.12 cM
Chr. · 2
Alpha-actinin-3 → Chromosome 11 (human), Chromosome 19 (mouse)
End · 2
Alpha-actinin-3 → 4,927,937 bp, 66,563,334 bp
Aliases · 1
Alpha-actinin-3 → ACTN3, actinin alpha 3 (gene/pseudogene), ACTN3D, actinin alpha 3
Available structures · 1
Alpha-actinin-3 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1TJT, 1WKU, 3LUE

Important terminology Word statistics

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Important terminology

gene actn3 muscle fibers protein bp chromosome human fast 11 chr band slow twitch skeletal alpha-actinin location also two actin

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Alpha-actinin-3AliasesACTN3, actinin alpha 3 (gene/pseudogene), ACTN3D, actinin alpha 31.00infobox
Alpha-actinin-3Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1TJT, 1WKU, 3LUE1.00infobox
Alpha-actinin-3Band11q13.21.00infobox
Alpha-actinin-3Band19 A|19 4.12 cM1.00infobox
Alpha-actinin-3BgeeSkeletal muscle tissue of rectus abdominis1.00infobox
Alpha-actinin-3BgeeSkeletal muscle tissue of biceps brachii1.00infobox
Alpha-actinin-3Bgeethoracic diaphragm1.00infobox
Alpha-actinin-3Bgeevastus lateralis muscle1.00infobox
Alpha-actinin-3Bgeemuscle of thigh1.00infobox
Alpha-actinin-3Bgeegastrocnemius muscle1.00infobox
Alpha-actinin-3Bgeetriceps brachii muscle1.00infobox
Alpha-actinin-3Bgeedeltoid muscle1.00infobox
Alpha-actinin-3Bgeetibialis anterior muscle1.00infobox
Alpha-actinin-3Bgeeglutes1.00infobox
Alpha-actinin-3Bgeesternocleidomastoid muscle1.00infobox
Alpha-actinin-3Bgeetemporal muscle1.00infobox
Alpha-actinin-3Bgeemedial head of gastrocnemius muscle1.00infobox
Alpha-actinin-3Bgeeextensor digitorum longus muscle1.00infobox
Alpha-actinin-3Bgeeankle1.00infobox
Alpha-actinin-3Bgeeplantaris muscle1.00infobox
Alpha-actinin-3BioGPSMore reference expression data1.00infobox
Alpha-actinin-3Chr.Chromosome 11 (human)1.00infobox
Alpha-actinin-3Chr.Chromosome 19 (mouse)1.00infobox
Alpha-actinin-3DatabasesNCBI: entry; OMA: entry1.00infobox
Alpha-actinin-3End66,563,334 bp1.00infobox
Alpha-actinin-3End4,927,937 bp1.00infobox
Alpha-actinin-3EnsemblENSG000002487461.00infobox
Alpha-actinin-3Entrez891.00infobox
Alpha-actinin-3External IDsOMIM: 102574; MGI: 99678; GeneCards: ACTN31.00infobox
Alpha-actinin-3Gene location (Human)Gene location (Human)Chr.Chromosome 11 (human)Band11q13.2Start66,546,395 bpEnd66,563,334 bp1.00infobox

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