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AAA proteins: Human proteins containing this domain, Overview & Functions

AAA (ATPases Associated with diverse cellular Activities) proteins (more commonly referred to as "triple-A ATPases") are a large group of protein family sharing a common conserved module of approximately 230 amino acid residues. This is a large, functionally diverse protein family belonging to the AAA+ protein superfamily of ring-shaped P-loop NTPases…

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AAA proteins topic overview

The analysis highlights Human proteins containing this domain, Overview and Functions as prominent areas in the source structure around AAA proteins.

Related topics
98
Source areas
7
Connected nodes
105
Extracted relationships
77
Concept neighborhoods
25
Bridge connections
105

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Human proteins containing this domain · 53 topics
Overview · 22 topics
Functions · 9 topics
Structure · 8 topics
Prokaryotic AAAs · 4 topics
Molecular mechanism · 1 topics
Quaternary structure · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

AlphaFold
IPR003959 · PF00004
Available protein structures:
IPR003959 · PF00004
CDD
cd00009
ECOD
2004.1.1
InterPro
IPR003959
Membranome
74

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Structure

Quaternary structure

Molecular mechanism

Prokaryotic AAAs

Functions

Human proteins containing this domain

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How AAA proteins connects Entity context

The extracted context around AAA proteins shows recurring relationship patterns in the source. For example, AAA proteins → AAA, ATPase, Cdc48p, Dyneins, E3, ER, ER-associated, ER-based E2, ERAD, Misfolded, Nonfunctional, On, Substrate, The AAA-type ATPase Cdc48p/p97, Ufd1p/Npl4p Another extracted example is AAA proteins → AAA, ATPase, Cdc48/p97, D1, D2, In, N-terminal, Pex1p, Pex6p, Sec18p/NSF, Some, While. Use these groups to spot repeated connection types before inspecting the individual relationships.

AAA proteins

Top relations

related to Molecular motion · 15
AAA proteins → AAA, ATPase, Cdc48p, Dyneins, E3, ER, ER-associated, ER-based E2, ERAD, Misfolded, Nonfunctional, On, Substrate, The AAA-type ATPase Cdc48p/p97, Ufd1p/Npl4p
related to Classification · 12
AAA proteins → AAA, ATPase, Cdc48/p97, D1, D2, In, N-terminal, Pex1p, Pex6p, Sec18p/NSF, Some, While
related to Prokaryotic AAAs · 11
AAA proteins → AAA, AAAs, ADP-bound, C-terminal, ClpAPS, ClpX/ClpY, HSP100, In HslU, Prokaryotes, The, Thereby
related to Structure · 10
AAA proteins → AAA, C-terminal, Most AAA, N-terminal, P-loop NTPases, Rossmann, The AAA, The N-terminal, These, Walker
related to Evolutionary relationships · 5
AAA proteins → AAA, H2-insert, HCLR, III, PS-II
AlphaFold · 2
AAA proteins → IPR003959, PF00004
Available protein structures: · 2
AAA proteins → IPR003959, PF00004
related to Functions · 2
AAA proteins → AAA, DNA
CDD · 1
AAA proteins → cd00009
ECOD · 1
AAA proteins → 2004.1.1

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

aaa proteins protein substrate family domains atpase degradation activity structure atp hydrolysis membrane domain p97 cdc48p conserved diverse proteasome n-terminal

AAA proteins relationships Subject–Predicate–Object triples

TTTA extracted 77 structured relationships around AAA proteins. Examples in this analysis include AAA proteins → AlphaFold → IPR003959 and AAA proteins → AlphaFold → PF00004. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
AAA proteinsAlphaFoldIPR0039591.00infobox
AAA proteinsAlphaFoldPF000041.00infobox
AAA proteinsAvailable protein structures:IPR0039591.00infobox
AAA proteinsAvailable protein structures:PF000041.00infobox
AAA proteinsCDDcd000091.00infobox
AAA proteinsECOD2004.1.11.00infobox
AAA proteinsInterProIPR0039591.00infobox
AAA proteinsMembranome741.00infobox
AAA proteinsPDBIPR003959 PF00004 (ECOD; PDBsum)1.00infobox
AAA proteinsPfamPF000041.00infobox
AAA proteinsPfam clanCL00231.00infobox
AAA proteinsPROSITEPDOC005721.00infobox
AAA proteinsSCOP21nsf / SCOPe / SUPFAM1.00infobox
AAA proteinsSymbolAAA1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around AAA proteins bring nearby vocabulary together. In this analysis, examples include Proteins, Family and Protein. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • AAA proteins
    • Proteins
    • Family
    • Protein
    • Domains
    • Molecular
    • Atpases
    • C-terminal
    • N-terminal
    • Structure
    • Activity
    • Atp
    • Domain
  • aaa proteins
    • Proteins
    • Family
    • Protein
    • Domains
    • Substrate
    • Molecular
    • Atpases
    • C-terminal
    • N-terminal
    • Structure
    • Activity
    • Atp
  • protein family
    • Large
    • Ntpases
    • P-loop
    • Activity
    • Degradation
    • Functions
    • Superfamily
    • Domain
    • Dna
    • Proteins
    • Cdc48p
    • P97
  • protein superfamily
    • Ntpases
    • P-loop
    • Activity
    • Degradation
    • Family
    • Functionally
    • Large
    • Diverse
    • Dna
    • N-terminal
    • Proteins
    • Cdc48p
  • protein degradation
    • Proteasome
    • Microtubule
    • Activity
    • Degradation
    • Protein
    • Dna
    • Involved
    • Membrane
    • Proteins
    • Cdc48p
    • P97
    • Atpase
  • protein aggregates
    • Activity
    • Degradation
    • Dna
    • Proteins
    • Cdc48p
    • P97
    • Atpase
    • Domains
    • Substrate
    • Microtubule
    • Regulation
    • Involved
  • motor protein
    • Activity
    • Degradation
    • Dna
    • Proteins
    • Cdc48p
    • P97
    • Atpase
    • Domains
    • Substrate
    • Microtubule
    • Regulation
    • Involved
  • human proteins containing this domain
    • N-terminal
    • Domains
    • Family
    • Atpase
    • Substrate
    • Molecular
    • Mechanism
    • Ntpases
    • P-loop
    • Structure
    • Domain
    • Membrane

Connections between topic areas Semantic bridges

For AAA proteins, one of the stronger structural bridges in this analysis connects AAA proteins with Human proteins containing this domain. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
AAA proteinsHuman proteins containing this domain · splits 52 ⟂ 54
AAA proteinsOverview · splits 83 ⟂ 23
AAA proteinsFunctions · splits 96 ⟂ 10
AAA proteinsStructure · splits 97 ⟂ 9
AAA proteinsProkaryotic AAAs · splits 101 ⟂ 5

Map overview Semantic statistics

AAA proteins

Nodes106
Edges105
Triples77
Avg. degree1.98
Density0.018868
Components1

Source & methodology

TTTA analyzes the structure around AAA proteins to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Human proteins containing this domain, Overview & Functions, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — AAA proteins · EN edition · Analysis: TopicsToTalkAbout

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