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PEX6: Standards, Function & Related diseases

Peroxisome assembly factor 2 is a protein that in humans is encoded by the PEX6 gene. PEX6 is an AAA ATPase that localizes to the peroxisome. PEX6 forms a hexamer with PEX1 and is recruited to the membrane by PEX26.

Language: English [EN]
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PEX6 topic overview

The analysis highlights Standards, Function and Related diseases as prominent areas in the source structure around PEX6.

Related topics
16
Source areas
3
Connected nodes
19
Extracted relationships
93
Concept neighborhoods
12
Bridge connections
19

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 6 topics
Function · 5 topics
Related diseases · 5 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
PEX6, PAF-2, PAF2, PBD4A, PDB4B, PXAAA1, HMLR2, peroxisomal biogenesis factor 6
Band
6p21.1 · 17|17 C
Bgee
right uterine tube · body of pancreas · mucosa of transverse colon · right hemisphere of cerebellum · right lobe of liver
BioGPS
More reference expression data
Chr.
Chromosome 6 (human) · Chromosome 17 (mouse)
Databases
NCBI: entry; OMA: entry

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Related diseases

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How PEX6 connects Entity context

The extracted context around PEX6 shows recurring relationship patterns in the source. For example, PEX6 → anterior pituitary, body of pancreas, brown adipose tissue, ciliary body, external carotid artery, internal carotid artery, left lobe of liver, left ovary, motor neuron, mucosa of transverse colon, Paneth cell, right adrenal gland, right frontal lobe, right hemisphere of cerebellum, right lobe of liver, right ovary, right uterine tube, Rostral migratory stream, transitional epithelium of urinary bladder, vas deferens Another extracted example is PEX6 → ATP binding, ATPase activity, cell projection, cytoplasm, cytosol, membrane, nucleotide binding, peroxisomal membrane, peroxisome, peroxisome organization, photoreceptor cell cilium, photoreceptor outer segment, protein binding, protein C-terminus binding, protein import into peroxisome matrix, protein import into peroxisome matrix, translocation, protein stabilization, protein targeting to peroxisome, protein-containing complex binding. Use these groups to spot repeated connection types before inspecting the individual relationships.

PEX6

Top relations

Bgee · 20
PEX6 → anterior pituitary, body of pancreas, brown adipose tissue, ciliary body, external carotid artery, internal carotid artery, left lobe of liver, left ovary, motor neuron, mucosa of transverse colon, Paneth cell, right adrenal gland, right frontal lobe, right hemisphere of cerebellum, right lobe of liver, right ovary, right uterine tube, Rostral migratory stream, transitional epithelium of urinary bladder, vas deferens
RNA expression pattern · 20
PEX6 → anterior pituitary, body of pancreas, brown adipose tissue, ciliary body, external carotid artery, internal carotid artery, left lobe of liver, left ovary, motor neuron, mucosa of transverse colon, Paneth cell, right adrenal gland, right frontal lobe, right hemisphere of cerebellum, right lobe of liver, right ovary, right uterine tube, Rostral migratory stream, transitional epithelium of urinary bladder, vas deferens
Gene ontology · 19
PEX6 → ATP binding, ATPase activity, cell projection, cytoplasm, cytosol, membrane, nucleotide binding, peroxisomal membrane, peroxisome, peroxisome organization, photoreceptor cell cilium, photoreceptor outer segment, protein binding, protein C-terminus binding, protein import into peroxisome matrix, protein import into peroxisome matrix, translocation, protein stabilization, protein targeting to peroxisome, protein-containing complex binding
related to Function · 6
PEX6 → Arabidopsis, From, Human PEX6, PEX1, PEX5, Work
related to Related diseases · 6
PEX6 → Because, Mutations, PEX1, Refsum, These, Zellweger Syndrome
Band · 2
PEX6 → 17|17 C, 6p21.1
Chr. · 2
PEX6 → Chromosome 17 (mouse), Chromosome 6 (human)
End · 2
PEX6 → 42,979,181 bp, 47,036,467 bp
is a · 2
PEX6 → AAA ATPase that localizes to the peroxisome, key player in the autophagy of peroxisomes called pexophagy
Aliases · 1
PEX6 → PEX6, PAF-2, PAF2, PBD4A, PDB4B, PXAAA1, HMLR2, peroxisomal biogenesis factor 6

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

bp human gene chr peroxisome band chromosome peroxisomal membrane external location pex1 function protein mouse biogenesis factor atpase mutants zellweger

PEX6 relationships Subject–Predicate–Object triples

TTTA extracted 93 structured relationships around PEX6. Examples in this analysis include PEX6 → Aliases → PEX6, PAF-2, PAF2, PBD4A, PDB4B, PXAAA1, HMLR2, peroxisomal biogenesis factor 6 and PEX6 → Band → 6p21.1. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
PEX6AliasesPEX6, PAF-2, PAF2, PBD4A, PDB4B, PXAAA1, HMLR2, peroxisomal biogenesis factor 61.00infobox
PEX6Band6p21.11.00infobox
PEX6Band17|17 C1.00infobox
PEX6Bgeeright uterine tube1.00infobox
PEX6Bgeebody of pancreas1.00infobox
PEX6Bgeemucosa of transverse colon1.00infobox
PEX6Bgeeright hemisphere of cerebellum1.00infobox
PEX6Bgeeright lobe of liver1.00infobox
PEX6Bgeeanterior pituitary1.00infobox
PEX6Bgeeright ovary1.00infobox
PEX6Bgeeleft ovary1.00infobox
PEX6Bgeeright frontal lobe1.00infobox
PEX6Bgeeright adrenal gland1.00infobox
PEX6BgeeRostral migratory stream1.00infobox
PEX6Bgeeinternal carotid artery1.00infobox
PEX6Bgeeleft lobe of liver1.00infobox
PEX6Bgeeexternal carotid artery1.00infobox
PEX6Bgeebrown adipose tissue1.00infobox
PEX6Bgeeciliary body1.00infobox
PEX6Bgeetransitional epithelium of urinary bladder1.00infobox
PEX6Bgeemotor neuron1.00infobox
PEX6BgeePaneth cell1.00infobox
PEX6Bgeevas deferens1.00infobox
PEX6BioGPSMore reference expression data1.00infobox
PEX6Chr.Chromosome 6 (human)1.00infobox
PEX6Chr.Chromosome 17 (mouse)1.00infobox
PEX6DatabasesNCBI: entry; OMA: entry1.00infobox
PEX6End42,979,181 bp1.00infobox
PEX6End47,036,467 bp1.00infobox
PEX6EnsemblENSG000001245871.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around PEX6 bring nearby vocabulary together. In this analysis, examples include Mutants, Peroxisomal and Pex1. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • PEX6
    • Mutants
    • Peroxisomal
    • Pex1
    • Human
    • Atpase
    • Body
    • External
    • Function
    • May
    • Membrane
    • Protein
    • Work
  • pex6
    • Mutants
    • Peroxisomal
    • Pex1
    • Human
    • Atpase
    • Body
    • External
    • Function
    • May
    • Membrane
    • Protein
    • Work
  • gene
    • Location
    • Chromosome
    • Bp
    • Chr
    • Human
    • End
    • External
    • Function
    • Humans
    • Mouse
    • Protein
    • Pex6
  • aaa atpase
    • Import
    • Peroxisome
    • Body
    • End
    • Entry
    • External
    • Function
    • Humans
    • May
    • Membrane
    • Mouse
    • Ncbi
  • peroxisome
    • Atpase
    • Entry
    • Humans
    • Ncbi
    • Protein
    • Gene
    • Pex6
    • Import
    • Body
    • End
    • External
    • Function
  • pex1
    • Membrane
    • Peroxisomal
    • Import
    • Pex26
    • Pex6
    • Body
    • End
    • Entry
    • External
    • Function
    • May
    • Mouse
  • oil body
    • May
    • Import
    • End
    • Entry
    • External
    • Function
    • Humans
    • Membrane
    • Mouse
    • Ncbi
    • Protein
    • Work
  • function
    • Location
    • Peroxisomal
    • Chromosome
    • Import
    • Bp
    • Chr
    • Gene
    • Human
    • Body
    • End
    • Entry
    • Humans

Connections between topic areas Semantic bridges

For PEX6, one of the stronger structural bridges in this analysis connects PEX6 with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
PEX6Overview · splits 13 ⟂ 7
PEX6Function · splits 14 ⟂ 6
PEX6Related diseases · splits 14 ⟂ 6

Map overview Semantic statistics

PEX6

Nodes20
Edges19
Triples93
Avg. degree1.9
Density0.1
Components1

Source & methodology

TTTA analyzes the structure around PEX6 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Standards, Function & Related diseases, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — PEX6 · EN edition · Analysis: TopicsToTalkAbout

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