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Thymic stromal lymphopoietin

Thymic stromal lymphopoietin (TSLP) is an interleukin (IL)-7-like cytokine, alarmin, and growth factor involved in numerous physiological and pathological processes, primarily those of the immune system. It shares a common ancestor with IL-7.

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Aliases
TSLP, thymic stromal lymphopoietin
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4NN5, 4NN6, 4NN7
Band
5q22.1 · 18 B1|18 18.12 cM
Bgee
pancreatic epithelial cell · gallbladder · cartilage tissue · right lobe of liver · right ventricle
BioGPS
n/a
Chr.
Chromosome 5 (human) · Chromosome 18 (mouse)

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Thymic stromal lymphopoietin

Nodes110
Edges109
Triples97
Avg. degree1.98
Density0.018182
Components1

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Thymic stromal lymphopoietin

Top relations

Gene ontology · 23
Thymic stromal lymphopoietin → antimicrobial humoral immune response mediated by antimicrobial peptide, cytokine activity, defense response to fungus, defense response to Gram-negative bacterium, extracellular region, extracellular space, interleukin-7 receptor binding, interleukin-7-mediated signaling pathway, negative regulation of apoptotic process, positive regulation of cell population proliferation, positive regulation of chemokine (C-C motif) ligand 1 production, positive regulation of chemokine production, positive regulation of cytokine-mediated signaling pathway, positive regulation of granulocyte colony-stimulating factor production, positive regulation of inflammatory response, positive regulation of interleukin-10 production, positive regulation of interleukin-13 production, positive regulation of interleukin-5 production, positive regulation of interleukin-6 production, positive regulation of mast cell activation
Bgee · 19
Thymic stromal lymphopoietin → apex of heart, atrioventricular valve, cartilage tissue, embryo, endothelial cell of lymphatic vessel, gallbladder, left lung lobe, myocardium of left ventricle, pancreatic epithelial cell, Paneth cell, prostate, right coronary artery, right lobe of liver, right lung, right lung lobe, right ventricle, secondary oocyte, urinary bladder, zygote
RNA expression pattern · 19
Thymic stromal lymphopoietin → apex of heart, atrioventricular valve, cartilage tissue, embryo, endothelial cell of lymphatic vessel, gallbladder, left lung lobe, myocardium of left ventricle, pancreatic epithelial cell, Paneth cell, prostate, right coronary artery, right lobe of liver, right lung, right lung lobe, right ventricle, secondary oocyte, urinary bladder, zygote
related to External links · 6
Thymic stromal lymphopoietin → Overview, PDB, PDBe-KB, Q969D9, Thymic, UniProt
Band · 2
Thymic stromal lymphopoietin → 18 B1|18 18.12 cM, 5q22.1
Chr. · 2
Thymic stromal lymphopoietin → Chromosome 18 (mouse), Chromosome 5 (human)
End · 2
Thymic stromal lymphopoietin → 111,078,026 bp, 32,952,850 bp
Aliases · 1
Thymic stromal lymphopoietin → TSLP, thymic stromal lymphopoietin
Available structures · 1
Thymic stromal lymphopoietin → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4NN5, 4NN6, 4NN7
BioGPS · 1
Thymic stromal lymphopoietin → n/a

Important terminology Word statistics

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Important terminology

tslp cells immune human bp sftslp stromal alarmin chr gene band responses epithelial mrna expression receptor cell pro-inflammatory thymic mouse

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Thymic stromal lymphopoietinAliasesTSLP, thymic stromal lymphopoietin1.00infobox
Thymic stromal lymphopoietinAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4NN5, 4NN6, 4NN71.00infobox
Thymic stromal lymphopoietinBand5q22.11.00infobox
Thymic stromal lymphopoietinBand18 B1|18 18.12 cM1.00infobox
Thymic stromal lymphopoietinBgeepancreatic epithelial cell1.00infobox
Thymic stromal lymphopoietinBgeegallbladder1.00infobox
Thymic stromal lymphopoietinBgeecartilage tissue1.00infobox
Thymic stromal lymphopoietinBgeeright lobe of liver1.00infobox
Thymic stromal lymphopoietinBgeeright ventricle1.00infobox
Thymic stromal lymphopoietinBgeemyocardium of left ventricle1.00infobox
Thymic stromal lymphopoietinBgeeapex of heart1.00infobox
Thymic stromal lymphopoietinBgeeurinary bladder1.00infobox
Thymic stromal lymphopoietinBgeeprostate1.00infobox
Thymic stromal lymphopoietinBgeeright coronary artery1.00infobox
Thymic stromal lymphopoietinBgeeembryo1.00infobox
Thymic stromal lymphopoietinBgeeleft lung lobe1.00infobox
Thymic stromal lymphopoietinBgeeendothelial cell of lymphatic vessel1.00infobox
Thymic stromal lymphopoietinBgeezygote1.00infobox
Thymic stromal lymphopoietinBgeePaneth cell1.00infobox
Thymic stromal lymphopoietinBgeeright lung1.00infobox
Thymic stromal lymphopoietinBgeeright lung lobe1.00infobox
Thymic stromal lymphopoietinBgeesecondary oocyte1.00infobox
Thymic stromal lymphopoietinBgeeatrioventricular valve1.00infobox
Thymic stromal lymphopoietinBioGPSn/a1.00infobox
Thymic stromal lymphopoietinChr.Chromosome 5 (human)1.00infobox
Thymic stromal lymphopoietinChr.Chromosome 18 (mouse)1.00infobox
Thymic stromal lymphopoietinDatabasesNCBI: entry; OMA: entry1.00infobox
Thymic stromal lymphopoietinEnd111,078,026 bp1.00infobox
Thymic stromal lymphopoietinEnd32,952,850 bp1.00infobox
Thymic stromal lymphopoietinEnsemblENSG000001457771.00infobox

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