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Triptan

Triptans are a family of antimigraine drugs used to abort migraines and cluster headaches. While effective at treating individual headaches, they do not provide preventive treatment and are not curative. They are not effective for the treatment of tension–type headache, except in persons who also experience migraines. Triptans do not relieve other kinds…

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ATC code
N02CC
Biological target
Serotonin 5-HT1B, 5-HT1D, and 5-HT1F receptors
Use
Migraine, cluster headache

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Overview

Medical uses

Contraindications

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Pharmacology

Chemistry

History

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Map overview Semantic statistics

Triptan

Nodes129
Edges128
Triples123
Avg. degree1.98
Density0.015504
Components1

How this topic connects Entity context

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Triptan

Top relations

related to Legal status · 25
Triptan → August, Brazil, Canada, December, FDA, Germany, Imigran, Imigran Recovery, Imitrex STATDose, It, January, July, June, May, Naratriptan, OTC, Romania, Sumatriptan, Sumavel Dosepro, The
related to Mechanism of action · 17
Triptan → After, All, CGRP, Each, HT, HT1, HT1A, HT1B, HT1D, HT1E, HT1F, HT3, HT7, Subtypes, Their, There, Triptans
related to Chemistry · 13
Triptan → Another, Certain, DMT, HT, IS-159, L-694247, LY-334370, LY-344864, Most, Naratriptan, Other, These, Triptans
related to Interactions · 13
Triptan → Combination, Combining, FDA, February, Florida College, Harvard Medical School, In, Medicine, SNRIs, SSRI, SSRIs, St John's, University
related to history · 12
Triptan → CNS, Glaxo, HT, Humphrey, In, Investigations, Italy, Later, Patrick, The, United States, US
related to Comparison · 7
Triptan → Donitriptan, HT1B, HT1D, In, N-desmethyl, They, Zolmitriptan
related to Contraindications · 7
Triptan → All, At, Canadian Blood Services, FDA, In, Most, Raynaud's
related to Cluster headache · 4
Triptan → Cochrane, Tablets, This, Triptans
related to Migraine · 4
Triptan → It, NSAIDs, They, Triptans
related to Pharmacokinetics · 4
Triptan → Bioavailability, T1/2, Their, Triptans

Important terminology Word statistics

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Important terminology

triptans sumatriptan 5-ht1d receptors migraine serotonin zolmitriptan rizatriptan 5-ht1b available also drugs pain may receptor effective tryptamines drug cluster including

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
TriptanATC codeN02CC1.00infobox
TriptanBiological targetSerotonin 5-HT1B, 5-HT1D, and 5-HT1F receptors1.00infobox
TriptanUseMigraine, cluster headache1.00infobox
ergotamine for all substances.At least two triptansinstance ofand combination with ergot alkaloids0.80text
ergot alkaloidsinstance ofInteractionsCombination of triptans with other serotonergic drugs0.80text
monoamine oxidase inhibitorsinstance ofInteractionsCombination of triptans with other serotonergic drugs0.80text
selective serotonin reuptake inhibitorsinstance ofInteractionsCombination of triptans with other serotonergic drugs0.80text
fluvoxamineinstance ofand frovatriptan levels by CYP1A2 inhibitors0.80text
CGRPinstance ofAn important initiator of head pain is suggested to be the activation of trigeminovascular afferent nerves which upon activation releases neuropeptides0.80text
substance Pinstance ofAn important initiator of head pain is suggested to be the activation of trigeminovascular afferent nerves which upon activation releases neuropeptides0.80text
neurokinin Ainstance ofAn important initiator of head pain is suggested to be the activation of trigeminovascular afferent nerves which upon activation releases neuropeptides0.80text
Triptanhas effectTriptans0.60section

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