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Toll-like receptor 3: Function, Structure & Ligands

Toll-like receptor 3 (TLR3) also known as CD283 (cluster of differentiation 283) is a protein that in humans is encoded by the TLR3 gene. TLR3 is a member of the toll-like receptor family of pattern recognition receptors of the innate immune system. TLR3 recognizes double-stranded RNA in endosomes, which is a common feature of viral genomes internalised…

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Toll-like receptor 3 topic overview

The analysis highlights Function, Structure and Ligands as prominent areas in the source structure around Toll-like receptor 3.

Related topics
35
Source areas
4
Connected nodes
39
Extracted relationships
151
Related term clusters
18
Bridge connections
39

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Function · 15 topics
Overview · 12 topics
Ligands · 4 topics
Structure · 4 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
TLR3, CD283, IIAE2, toll like receptor 3, IMD83
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1ZIW, 2A0Z, 3ULU, 3ULV, 2MK9, 2MKA
Band
4q35.1 · 8|8 B1.1
Bgee
jejunal mucosa · palpebral conjunctiva · placenta · rectum · sperm
BioGPS
More reference expression data
Chr.
Chromosome 4 (human) · Chromosome 8 (mouse)

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Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Structure

Function

Ligands

For the semantics nerds

You can skip this section if you’re here for content ideas and keyword inspiration.

Advanced semantic analysis

How Toll-like receptor 3 connects Entity context

The extracted context around Toll-like receptor 3 shows recurring relationship patterns in the source. For example, Toll-like receptor 3 → activation of NF-kappaB-inducing kinase activity, apoptotic signaling pathway, cell surface, cellular response to dsRNA, cellular response to exogenous dsRNA, cellular response to interferon-beta, cellular response to interferon-gamma, cellular response to mechanical stimulus, cytoplasm, defense response, defense response to bacterium, defense response to virus, detection of virus, double-stranded RNA binding, early endosome, endolysosome membrane, endoplasmic reticulum, endoplasmic reticulum membrane, endosome, endosome membrane Another extracted example is Toll-like receptor 3 → Achilles tendon, conjunctival fornix, duodenum, Epithelium of choroid plexus, epithelium of colon, gallbladder, gastrula, jejunal mucosa, jejunum, lumbar subsegment of spinal cord, palpebral conjunctiva, pancreatic epithelial cell, placenta, rectum, secondary oocyte, sperm, stria vascularis, transitional epithelium of urinary bladder, vestibular membrane of cochlear duct, vestibular sensory epithelium. Use these groups to spot repeated connection types before inspecting the individual relationships.

Toll-like receptor 3

Top relations

Gene ontology · 76
Toll-like receptor 3 → activation of NF-kappaB-inducing kinase activity, apoptotic signaling pathway, cell surface, cellular response to dsRNA, cellular response to exogenous dsRNA, cellular response to interferon-beta, cellular response to interferon-gamma, cellular response to mechanical stimulus, cytoplasm, defense response, defense response to bacterium, defense response to virus, detection of virus, double-stranded RNA binding, early endosome, endolysosome membrane, endoplasmic reticulum, endoplasmic reticulum membrane, endosome, endosome membrane
Bgee · 20
Toll-like receptor 3 → Achilles tendon, conjunctival fornix, duodenum, Epithelium of choroid plexus, epithelium of colon, gallbladder, gastrula, jejunal mucosa, jejunum, lumbar subsegment of spinal cord, palpebral conjunctiva, pancreatic epithelial cell, placenta, rectum, secondary oocyte, sperm, stria vascularis, transitional epithelium of urinary bladder, vestibular membrane of cochlear duct, vestibular sensory epithelium
RNA expression pattern · 20
Toll-like receptor 3 → Achilles tendon, conjunctival fornix, duodenum, Epithelium of choroid plexus, epithelium of colon, gallbladder, gastrula, jejunal mucosa, jejunum, lumbar subsegment of spinal cord, palpebral conjunctiva, pancreatic epithelial cell, placenta, rectum, secondary oocyte, sperm, stria vascularis, transitional epithelium of urinary bladder, vestibular membrane of cochlear duct, vestibular sensory epithelium
related to Structure · 10
Toll-like receptor 3 → C-terminal, LRRs, PF01582, PF13516, PF13855, PF17968, TIR, TLR3, Toll-like, Toll/interleukin-1
Band · 2
Toll-like receptor 3 → 4q35.1, 8|8 B1.1
Chr. · 2
Toll-like receptor 3 → Chromosome 4 (human), Chromosome 8 (mouse)
End · 2
Toll-like receptor 3 → 186,088,073 bp, 45,864,117 bp
Aliases · 1
Toll-like receptor 3 → TLR3, CD283, IIAE2, toll like receptor 3, IMD83
Available structures · 1
Toll-like receptor 3 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1ZIW, 2A0Z, 3ULU, 3ULV, 2MK9, 2MKA
BioGPS · 1
Toll-like receptor 3 → More reference expression data

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

tlr3 receptor bp activation human rna toll-like chr band gene dsrna double-stranded chromosome dendritic cells mouse production type innate location

Toll-like receptor 3 relationships Subject–Predicate–Object triples

TTTA extracted 151 structured relationships around Toll-like receptor 3. Examples in this analysis include Toll-like receptor 3 → Aliases → TLR3, CD283, IIAE2, toll like receptor 3, IMD83 and Toll-like receptor 3 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1ZIW, 2A0Z, 3ULU, 3ULV, 2MK9, 2MKA. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Toll-like receptor 3AliasesTLR3, CD283, IIAE2, toll like receptor 3, IMD831.00infobox
Toll-like receptor 3Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1ZIW, 2A0Z, 3ULU, 3ULV, 2MK9, 2MKA1.00infobox
Toll-like receptor 3Band4q35.11.00infobox
Toll-like receptor 3Band8|8 B1.11.00infobox
Toll-like receptor 3Bgeejejunal mucosa1.00infobox
Toll-like receptor 3Bgeepalpebral conjunctiva1.00infobox
Toll-like receptor 3Bgeeplacenta1.00infobox
Toll-like receptor 3Bgeerectum1.00infobox
Toll-like receptor 3Bgeesperm1.00infobox
Toll-like receptor 3Bgeeduodenum1.00infobox
Toll-like receptor 3Bgeegallbladder1.00infobox
Toll-like receptor 3BgeeAchilles tendon1.00infobox
Toll-like receptor 3Bgeeepithelium of colon1.00infobox
Toll-like receptor 3Bgeepancreatic epithelial cell1.00infobox
Toll-like receptor 3Bgeeconjunctival fornix1.00infobox
Toll-like receptor 3Bgeegastrula1.00infobox
Toll-like receptor 3Bgeestria vascularis1.00infobox
Toll-like receptor 3Bgeetransitional epithelium of urinary bladder1.00infobox
Toll-like receptor 3Bgeevestibular membrane of cochlear duct1.00infobox
Toll-like receptor 3Bgeevestibular sensory epithelium1.00infobox
Toll-like receptor 3Bgeesecondary oocyte1.00infobox
Toll-like receptor 3Bgeelumbar subsegment of spinal cord1.00infobox
Toll-like receptor 3BgeeEpithelium of choroid plexus1.00infobox
Toll-like receptor 3Bgeejejunum1.00infobox
Toll-like receptor 3BioGPSMore reference expression data1.00infobox
Toll-like receptor 3Chr.Chromosome 4 (human)1.00infobox
Toll-like receptor 3Chr.Chromosome 8 (mouse)1.00infobox
Toll-like receptor 3DatabasesNCBI: entry; OMA: entry1.00infobox
Toll-like receptor 3End186,088,073 bp1.00infobox
Toll-like receptor 3End45,864,117 bp1.00infobox

Related concept clusters Related term clusters

The concept neighborhoods around Toll-like receptor 3 bring nearby vocabulary together. In this analysis, examples include Toll-like, Innate and Gene. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Toll-like receptor 3
    • Toll-like
    • Innate
    • Gene
    • Tlr3
    • Cd283
    • Differentiation
    • Function
    • Immune
    • Pattern
    • Protein
    • System
    • Dendritic
  • toll-like receptor 3
    • Toll-like
    • Innate
    • Gene
    • Tlr3
    • Cd283
    • Differentiation
    • Function
    • Immune
    • Pattern
    • Protein
    • System
    • Dendritic
  • cluster of differentiation
    • Protein
    • Gene
    • Toll-like
    • Function
    • Immune
    • Pattern
    • Receptor
    • Signaling
    • System
    • Dendritic
    • Expressed
    • Innate
  • protein
    • Gene
    • Toll-like
    • Function
    • Immune
    • Pattern
    • Receptor
    • Signaling
    • System
    • Dendritic
    • Expressed
    • Innate
    • Location
  • gene
    • Location
    • Chromosome
    • Bp
    • Chr
    • Function
    • Human
    • Protein
    • Receptor
    • Mouse
    • Structure
    • Band
    • Toll-like
  • toll-like receptor
    • Toll-like
    • Innate
    • Gene
    • Tlr3
    • Cd283
    • Differentiation
    • Function
    • Immune
    • Pattern
    • Protein
    • System
    • Dendritic
  • pattern recognition receptors
    • Immune
    • System
    • Innate
    • Toll-like
    • Function
    • Protein
    • Receptor
    • Signaling
    • Dendritic
    • Expressed
    • Location
    • Mouse
  • innate immune system
    • Pattern
    • System
    • Toll-like
    • Immune
    • Innate
    • Receptor
    • Recognition
    • Function
    • Protein
    • Signaling
    • Dendritic
    • Expressed

Connections between topic areas Semantic bridges

For Toll-like receptor 3, one of the stronger structural bridges in this analysis connects Toll-like receptor 3 with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Toll-like receptor 3 — Function · splits 24 ⟂ 16
Toll-like receptor 3 — Overview · splits 27 ⟂ 13
Toll-like receptor 3 — Structure · splits 35 ⟂ 5
Toll-like receptor 3 — Ligands · splits 35 ⟂ 5

Map overview Semantic statistics

Toll-like receptor 3

Nodes40
Edges39
Triples151
Avg. degree1.95
Density0.05
Components1

Source & methodology

TTTA analyzes the structure around Toll-like receptor 3 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Function, Structure & Ligands, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Toll-like receptor 3 · EN edition · Analysis: TopicsToTalkAbout

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