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Toll-like receptor 3 (TLR3) also known as CD283 (cluster of differentiation 283) is a protein that in humans is encoded by the TLR3 gene. TLR3 is a member of the toll-like receptor family of pattern recognition receptors of the innate immune system. TLR3 recognizes double-stranded RNA in endosomes, which is a common feature of viral genomes internalised…
The analysis highlights Function, Structure and Ligands as prominent areas in the source structure around Toll-like receptor 3.
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Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
High-confidence facts extracted from structured source data. Use them as anchors for further research.
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The extracted context around Toll-like receptor 3 shows recurring relationship patterns in the source. For example, Toll-like receptor 3 → activation of NF-kappaB-inducing kinase activity, apoptotic signaling pathway, cell surface, cellular response to dsRNA, cellular response to exogenous dsRNA, cellular response to interferon-beta, cellular response to interferon-gamma, cellular response to mechanical stimulus, cytoplasm, defense response, defense response to bacterium, defense response to virus, detection of virus, double-stranded RNA binding, early endosome, endolysosome membrane, endoplasmic reticulum, endoplasmic reticulum membrane, endosome, endosome membrane Another extracted example is Toll-like receptor 3 → Achilles tendon, conjunctival fornix, duodenum, Epithelium of choroid plexus, epithelium of colon, gallbladder, gastrula, jejunal mucosa, jejunum, lumbar subsegment of spinal cord, palpebral conjunctiva, pancreatic epithelial cell, placenta, rectum, secondary oocyte, sperm, stria vascularis, transitional epithelium of urinary bladder, vestibular membrane of cochlear duct, vestibular sensory epithelium. Use these groups to spot repeated connection types before inspecting the individual relationships.
Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.
tlr3 receptor bp activation human rna toll-like chr band gene dsrna double-stranded chromosome dendritic cells mouse production type innate location
TTTA extracted 151 structured relationships around Toll-like receptor 3. Examples in this analysis include Toll-like receptor 3 → Aliases → TLR3, CD283, IIAE2, toll like receptor 3, IMD83 and Toll-like receptor 3 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1ZIW, 2A0Z, 3ULU, 3ULV, 2MK9, 2MKA. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| Toll-like receptor 3 | Aliases | TLR3, CD283, IIAE2, toll like receptor 3, IMD83 | 1.00 | infobox |
| Toll-like receptor 3 | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1ZIW, 2A0Z, 3ULU, 3ULV, 2MK9, 2MKA | 1.00 | infobox |
| Toll-like receptor 3 | Band | 4q35.1 | 1.00 | infobox |
| Toll-like receptor 3 | Band | 8|8 B1.1 | 1.00 | infobox |
| Toll-like receptor 3 | Bgee | jejunal mucosa | 1.00 | infobox |
| Toll-like receptor 3 | Bgee | palpebral conjunctiva | 1.00 | infobox |
| Toll-like receptor 3 | Bgee | placenta | 1.00 | infobox |
| Toll-like receptor 3 | Bgee | rectum | 1.00 | infobox |
| Toll-like receptor 3 | Bgee | sperm | 1.00 | infobox |
| Toll-like receptor 3 | Bgee | duodenum | 1.00 | infobox |
| Toll-like receptor 3 | Bgee | gallbladder | 1.00 | infobox |
| Toll-like receptor 3 | Bgee | Achilles tendon | 1.00 | infobox |
| Toll-like receptor 3 | Bgee | epithelium of colon | 1.00 | infobox |
| Toll-like receptor 3 | Bgee | pancreatic epithelial cell | 1.00 | infobox |
| Toll-like receptor 3 | Bgee | conjunctival fornix | 1.00 | infobox |
| Toll-like receptor 3 | Bgee | gastrula | 1.00 | infobox |
| Toll-like receptor 3 | Bgee | stria vascularis | 1.00 | infobox |
| Toll-like receptor 3 | Bgee | transitional epithelium of urinary bladder | 1.00 | infobox |
| Toll-like receptor 3 | Bgee | vestibular membrane of cochlear duct | 1.00 | infobox |
| Toll-like receptor 3 | Bgee | vestibular sensory epithelium | 1.00 | infobox |
| Toll-like receptor 3 | Bgee | secondary oocyte | 1.00 | infobox |
| Toll-like receptor 3 | Bgee | lumbar subsegment of spinal cord | 1.00 | infobox |
| Toll-like receptor 3 | Bgee | Epithelium of choroid plexus | 1.00 | infobox |
| Toll-like receptor 3 | Bgee | jejunum | 1.00 | infobox |
| Toll-like receptor 3 | BioGPS | More reference expression data | 1.00 | infobox |
| Toll-like receptor 3 | Chr. | Chromosome 4 (human) | 1.00 | infobox |
| Toll-like receptor 3 | Chr. | Chromosome 8 (mouse) | 1.00 | infobox |
| Toll-like receptor 3 | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| Toll-like receptor 3 | End | 186,088,073 bp | 1.00 | infobox |
| Toll-like receptor 3 | End | 45,864,117 bp | 1.00 | infobox |
The concept neighborhoods around Toll-like receptor 3 bring nearby vocabulary together. In this analysis, examples include Toll-like, Innate and Gene. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For Toll-like receptor 3, one of the stronger structural bridges in this analysis connects Toll-like receptor 3 with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around Toll-like receptor 3 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Function, Structure & Ligands, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — Toll-like receptor 3 · EN edition · Analysis: TopicsToTalkAbout