RIG-I

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Explore the main themes, entities and connections around RIG-I. Start with the topic map, then use the sections below for research and deeper semantic analysis.

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Overview

DEAD box Cytosolic Pattern recognition receptor Type-I interferon Innate immune system

28 related topics

Structure

Gene RNA helicase C-terminus N-terminus RIG-I like receptors

8 related topics

Function

Virus Pathogen-associated molecular patterns Type-I interferon Proinflammatory cytokines IFNα

7 related topics

History

All-trans retinoic acid

1 related topics

Key facts & relationships

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3.6.4.13: ↗
Aliases: RIGI, DEAD (Asp-Glu-Ala-Asp) box polypeptide 58, RLR-1, SGMRT2, RIG-I, DEXD/H-box helicase 58, RIG1, DDX58, RNA sensor RIG-I
Available structures: Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2LWD, 2LWE, 2QFB, 2QFD, 2RMJ, 2YKG, 3LRN, 3LRR, 3NCU, 3OG8, 3ZD6, 3ZD7, 4AY2, 4BPB, 4NQK, 4ON9, 4P4H, 5E3H,…
Band: 9p21.1 · 4|4 A5
Bgee: buccal mucosa cell · skin of thigh · tendon of biceps brachii · white blood cell · monocyte
BioGPS: More reference expression data

Topics to explore

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Overview

DEAD box
Cytosolic Cytosol
Pattern recognition receptor
Type-I interferon Interferon type I
Innate immune system
West Nile virus
Japanese Encephalitis virus Japanese encephalitis
Influenza A
Sendai virus
Flavivirus
Coronaviruses Coronavirus
DExD/H box DExD/H box proteins
RNA helicase
Double-stranded RNA
5' 7-methyl guanosine (m7G) cap Five-prime cap
MAVS MAVS (gene)
CARD domains CARD domain
Adaptive immune system
Orthologs Ortholog
Knockout mice Knockout mouse
DNA-dependent RNA polymerase III RNA polymerase III
Breast cancer
Myeloid leukemia
Hepatocellular carcinoma
Oncoviruses Oncovirus
Apoptosis
Caspase-3 Caspase 3
Natural killer cells Natural killer cell

Structure

Gene
RNA helicase
C-terminus
N-terminus
RIG-I like receptors RIG-I-like receptor
Melanoma Differentiation-Associated protein 5 MDA5
LGP2
MAVS VISA (gene)

Regulation

Function

Virus
Pathogen-associated molecular patterns Pathogen-associated molecular pattern
Type-I interferon Type-I interferon?action=edit&redlink=1
Proinflammatory cytokines Inflammatory cytokine
IFNα
IFNβ) IFN-β
JAK-STAT JAK-STAT signaling pathway

History

All-trans retinoic acid Tretinoin

Advanced semantic analysis

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Map overview Semantic statistics

Nodes52

Edges51

Triples191

Avg. degree1.96

Density0.038462

Components1

How this topic connects Entity context

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RIG-I

Top relations

Gene ontology · 49

RIG-I → actin cytoskeleton, ATP binding, bicellular tight junction, cell junction, cell projection, cellular response to exogenous dsRNA, cytoplasm, cytoplasmic pattern recognition receptor signaling pathway in response to virus, cytoskeleton, cytosol, defense response to virus, detection of virus, double-stranded DNA binding, double-stranded RNA binding, helicase activity, hydrolase activity, identical protein binding, immune system process, innate immune response, membrane

related to Type-1 interferon pathway · 21

RIG-I → Although RIG-I, CARD, CARDs, IFN-stimulated, IFN1, IFN1s, IFNα, IFNβ, Interferon, ISGs, JAK-STAT, MAVS, MAVS CARD, Once, Once RIG-I, PACT, PAMP, RIG-I CARD, The, This

Bgee · 19

RIG-I → Achilles tendon, blood, buccal mucosa cell, calvaria, epithelium of small intestine, granulocyte, internal globus pallidus, jejunum, lumbar spinal ganglion, mesenteric lymph nodes, monocyte, otolith organ, skin of thigh, spleen, superficial temporal artery, tendon of biceps brachii, utricle, white blood cell, zygote

RNA expression pattern · 19

related to Structure · 14

RIG-I → ATP-dependent DExD/H, C-terminus, CARDs, DDX58, Laboratory, LGP2, MAVS, MDA5, Melanoma Differentiation-Associated, N-terminus, On, RD, RLRs, RNA

related to Ligands · 9

RIG-I → As, Cells, It, N1, Native RNA, O-methyl, RNA, RNAs, The PAMP

related to history · 7

RIG-I → ATRA, Hematology, In, RIG, RIG-A, RIG-B, Shanghai Institute

related to Regulation · 6

RIG-I → For, LGP2, N-terminus, RIG-I-mediated, STING, The

related to Function · 5

RIG-I → In, Once, PAMP, PRR's, PRRs

related to Mechanism · 5

RIG-I → It, Less, O-methyl, On, RNA

Important terminology Word statistics

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Important terminology

rna gene cells dsrna system also cell response immune interferon virus signaling innate bp mavs pathway ifn1 helicase binding viral

Entity relationships Subject–Predicate–Object triples

Subject	Predicate	Object	Confidence	Src
RIG-I	3.6.4.13	↗	1.00	infobox
RIG-I	Aliases	RIGI, DEAD (Asp-Glu-Ala-Asp) box polypeptide 58, RLR-1, SGMRT2, RIG-I, DEXD/H-box helicase 58, RIG1, DDX58, RNA sensor RIG-I	1.00	infobox
RIG-I	Available structures	Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2LWD, 2LWE, 2QFB, 2QFD, 2RMJ, 2YKG, 3LRN, 3LRR, 3NCU, 3OG8, 3ZD6, 3ZD7, 4AY2, 4BPB, 4NQK, 4ON9, 4P4H, 5E3H,…	1.00	infobox
RIG-I	Band	9p21.1	1.00	infobox
RIG-I	Band	4\|4 A5	1.00	infobox
RIG-I	Bgee	buccal mucosa cell	1.00	infobox
RIG-I	Bgee	skin of thigh	1.00	infobox
RIG-I	Bgee	tendon of biceps brachii	1.00	infobox
RIG-I	Bgee	white blood cell	1.00	infobox
RIG-I	Bgee	monocyte	1.00	infobox
RIG-I	Bgee	blood	1.00	infobox
RIG-I	Bgee	Achilles tendon	1.00	infobox
RIG-I	Bgee	granulocyte	1.00	infobox
RIG-I	Bgee	internal globus pallidus	1.00	infobox
RIG-I	Bgee	superficial temporal artery	1.00	infobox
RIG-I	Bgee	mesenteric lymph nodes	1.00	infobox
RIG-I	Bgee	lumbar spinal ganglion	1.00	infobox
RIG-I	Bgee	otolith organ	1.00	infobox
RIG-I	Bgee	utricle	1.00	infobox
RIG-I	Bgee	jejunum	1.00	infobox
RIG-I	Bgee	spleen	1.00	infobox
RIG-I	Bgee	calvaria	1.00	infobox
RIG-I	Bgee	epithelium of small intestine	1.00	infobox
RIG-I	Bgee	zygote	1.00	infobox
RIG-I	BioGPS	More reference expression data	1.00	infobox
RIG-I	Chr.	Chromosome 9 (human)	1.00	infobox
RIG-I	Chr.	Chromosome 4 (mouse)	1.00	infobox
RIG-I	Databases	NCBI: entry; OMA: entry	1.00	infobox
RIG-I	End	32,526,208 bp	1.00	infobox
RIG-I	End	40,239,828 bp	1.00	infobox

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