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Thiamine transporter 1: Standards, Clinical significance & Structure

Thiamine transporter 1, also known as thiamine carrier 1 (TC1) or solute carrier family 19 member 2 (SLC19A2) is a protein that in humans is encoded by the SLC19A2 gene. SLC19A2 is a thiamine transporter. Mutations in this gene cause thiamine-responsive megaloblastic anemia syndrome (TRMA), which is an autosomal recessive disorder characterized by…

Language: English [EN]

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Thiamine transporter 1 topic overview

The analysis highlights Standards, Clinical significance and Structure as prominent areas in the source structure around Thiamine transporter 1.

Related topics: 56
Source areas: 5
Connected nodes: 61
Extracted relationships: 73
Concept neighborhoods: 20
Bridge connections: 61

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Clinical significance · 19 topics

Structure · 17 topics

Overview · 10 topics

Function · 8 topics

Interactions · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases: SLC19A2, TC1, THMD1, THT1, THTR1, TRMA, solute carrier family 19 member 2
Band: 1q24.2 · 1 H2.2|1 71.56 cM
Bgee: secondary oocyte · gastrocnemius muscle · tibialis anterior muscle · Skeletal muscle tissue of rectus abdominis · biceps brachii
BioGPS: n/a
Chr.: Chromosome 1 (human) · Chromosome 1 (mouse)
Databases: NCBI: entry; OMA: entry

Suggested research paths

A focused starting point derived from the topic graph, ranked independently of the source article order.

Start with these areas

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Protein
Gene
Thiamine
Transporter Membrane transport protein
Mutations Mutation
Thiamine-responsive megaloblastic anemia syndrome (TRMA) Thiamine responsive megaloblastic anemia syndrome
Autosomal recessive Genetic disorder
Diabetes mellitus
Megaloblastic anemia
Sensorineural deafness Sensorineural hearing loss

Structure

Chromosome 1
Amino acids
Membrane protein Integral membrane protein
Cell membrane
N-terminus
C-terminus
Cytosol
Exons Exon
Putative Putative gene
Transmembrane domains Transmembrane domain
Phosphorylation sites Protein phosphorylation
N-glycolysation N-linked glycosylation
G protein-coupled receptor
Shared amino acid identity Sequence homology
Folate
SLC19A1
Localization Protein subcellular localization prediction

Function

Specific Chemical specificity
Inhibited Competitive inhibition
Sodium ion Sodium
Proton gradient Chemiosmosis
PH
Transported Intracellular transport
Vesicles Vesicle (biology and chemistry)
Microtubules Microtubule

Clinical significance

Onset Age of onset
Infancy Infant
Adolescence
Anemia
Optic atrophy Optic neuropathy
Congenital heart defects Congenital heart defect
Stroke
Transcript Primary transcript
Gene expression
Skeletal Skeletal muscle
Cardiac muscle
Placenta
Heart
Liver
Kidney
Lung
Melanocytic cells Melanocyte
Regulated Regulation of gene expression
MITF Microphthalmia-associated transcription factor

Interactions

Interacts Protein-protein interactions
CERS2 Ceramide synthase 2

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Thiamine transporter 1 connects Entity context

The extracted context around Thiamine transporter 1 shows recurring relationship patterns in the source. For example, Thiamine transporter 1 → biceps brachii, body of tongue, buccal mucosa cell, cornea, cumulus cell, deltoid muscle, endothelial cell of lymphatic vessel, facial motor nucleus, gastric mucosa, gastrocnemius muscle, interventricular septum, left lobe of liver, medullary collecting duct, motor neuron, muscle of thigh, retinal pigment epithelium, secondary oocyte, Skeletal muscle tissue of rectus abdominis, spermatocyte, tibialis anterior muscle Another extracted example is Thiamine transporter 1 → folic acid transmembrane transporter activity, folic acid transport, integral component of membrane, membrane, plasma membrane, protein binding, thiamine transmembrane transport, thiamine transmembrane transporter activity, thiamine transport, thiamine-containing compound metabolic process, transmembrane transport, vitamin transmembrane transporter activity, vitamin transport. Use these groups to spot repeated connection types before inspecting the individual relationships.

Thiamine transporter 1

Top relations

Bgee · 20

Thiamine transporter 1 → biceps brachii, body of tongue, buccal mucosa cell, cornea, cumulus cell, deltoid muscle, endothelial cell of lymphatic vessel, facial motor nucleus, gastric mucosa, gastrocnemius muscle, interventricular septum, left lobe of liver, medullary collecting duct, motor neuron, muscle of thigh, retinal pigment epithelium, secondary oocyte, Skeletal muscle tissue of rectus abdominis, spermatocyte, tibialis anterior muscle

RNA expression pattern · 20

Gene ontology · 13

Thiamine transporter 1 → folic acid transmembrane transporter activity, folic acid transport, integral component of membrane, membrane, plasma membrane, protein binding, thiamine transmembrane transport, thiamine transmembrane transporter activity, thiamine transport, thiamine-containing compound metabolic process, transmembrane transport, vitamin transmembrane transporter activity, vitamin transport

Band · 2

Thiamine transporter 1 → 1 H2.2|1 71.56 cM, 1q24.2

Chr. · 2

Thiamine transporter 1 → Chromosome 1 (human), Chromosome 1 (mouse)

End · 2

Thiamine transporter 1 → 164,092,954 bp, 169,485,944 bp

Aliases · 1

Thiamine transporter 1 → SLC19A2, TC1, THMD1, THT1, THTR1, TRMA, solute carrier family 19 member 2

BioGPS · 1

Thiamine transporter 1 → n/a

Databases · 1

Thiamine transporter 1 → NCBI: entry; OMA: entry

Ensembl · 1

Thiamine transporter 1 → ENSG00000117479

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

gene slc19a2 protein thiamine bp human transporter chr band chromosome anemia tc1 encoded membrane cell trma location thiamine-responsive megaloblastic syndrome

Thiamine transporter 1 relationships Subject–Predicate–Object triples

TTTA extracted 73 structured relationships around Thiamine transporter 1. Examples in this analysis include Thiamine transporter 1 → Aliases → SLC19A2, TC1, THMD1, THT1, THTR1, TRMA, solute carrier family 19 member 2 and Thiamine transporter 1 → Band → 1q24.2. The table shows each extracted connection, where it came from and its confidence.

Subject	Predicate	Object	Confidence	Src
Thiamine transporter 1	Aliases	SLC19A2, TC1, THMD1, THT1, THTR1, TRMA, solute carrier family 19 member 2	1.00	infobox
Thiamine transporter 1	Band	1q24.2	1.00	infobox
Thiamine transporter 1	Band	1 H2.2\|1 71.56 cM	1.00	infobox
Thiamine transporter 1	Bgee	secondary oocyte	1.00	infobox
Thiamine transporter 1	Bgee	gastrocnemius muscle	1.00	infobox
Thiamine transporter 1	Bgee	tibialis anterior muscle	1.00	infobox
Thiamine transporter 1	Bgee	Skeletal muscle tissue of rectus abdominis	1.00	infobox
Thiamine transporter 1	Bgee	biceps brachii	1.00	infobox
Thiamine transporter 1	Bgee	deltoid muscle	1.00	infobox
Thiamine transporter 1	Bgee	muscle of thigh	1.00	infobox
Thiamine transporter 1	Bgee	gastric mucosa	1.00	infobox
Thiamine transporter 1	Bgee	buccal mucosa cell	1.00	infobox
Thiamine transporter 1	Bgee	body of tongue	1.00	infobox
Thiamine transporter 1	Bgee	retinal pigment epithelium	1.00	infobox
Thiamine transporter 1	Bgee	left lobe of liver	1.00	infobox
Thiamine transporter 1	Bgee	facial motor nucleus	1.00	infobox
Thiamine transporter 1	Bgee	medullary collecting duct	1.00	infobox
Thiamine transporter 1	Bgee	cornea	1.00	infobox
Thiamine transporter 1	Bgee	endothelial cell of lymphatic vessel	1.00	infobox
Thiamine transporter 1	Bgee	interventricular septum	1.00	infobox
Thiamine transporter 1	Bgee	motor neuron	1.00	infobox
Thiamine transporter 1	Bgee	cumulus cell	1.00	infobox
Thiamine transporter 1	Bgee	spermatocyte	1.00	infobox
Thiamine transporter 1	BioGPS	n/a	1.00	infobox
Thiamine transporter 1	Chr.	Chromosome 1 (human)	1.00	infobox
Thiamine transporter 1	Chr.	Chromosome 1 (mouse)	1.00	infobox
Thiamine transporter 1	Databases	NCBI: entry; OMA: entry	1.00	infobox
Thiamine transporter 1	End	169,485,944 bp	1.00	infobox
Thiamine transporter 1	End	164,092,954 bp	1.00	infobox
Thiamine transporter 1	Ensembl	ENSG00000117479	1.00	infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Thiamine transporter 1 bring nearby vocabulary together. In this analysis, examples include Thiamine, Transporter and Encoded. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

Thiamine transporter 1
- Thiamine
- Transporter
- Encoded
- Slc19a2
- Protein
- Acid
- Gene
- Carrier
- Family
- Function
- Member
- Mouse
thiamine transporter 1
- Thiamine
- Transporter
- Encoded
- Slc19a2
- Protein
- Acid
- Carrier
- Family
- Function
- Gene
- Member
- Mouse
protein
- Encoded
- Transporter
- Thiamine
- Acid
- Transmembrane
- Slc19a2
- Cell
- Membrane
- Gene
- Tc1
- Human
- Function
gene
- Slc19a2
- Location
- Trma
- Chromosome
- Bp
- Chr
- Human
- Protein
- Autosomal
- Cause
- Characterized
- Deafness
thiamine
- Transporter
- Encoded
- Slc19a2
- Protein
- Acid
- Gene
- Carrier
- Family
- Function
- Member
- Mouse
- Solute
thiamine-responsive megaloblastic anemia syndrome (trma)
- Syndrome
- Thiamine-responsive
- Anemia
- Diabetes
- Megaloblastic
- Autosomal
- Cause
- Characterized
- Deafness
- Mellitus
- Mutations
- Recessive
membrane protein
- Encoded
- Transmembrane
- Transporter
- Tc1
- Thiamine
- Acid
- Slc19a2
- Cell
- Membrane
- Protein
- Gene
- Mouse
gene expression
- Slc19a2
- Location
- Trma
- Chromosome
- Bp
- Chr
- Human
- Protein
- Function
- Mouse
- Autosomal
- Cause

Connections between topic areas Semantic bridges

For Thiamine transporter 1, one of the stronger structural bridges in this analysis connects Thiamine transporter 1 with Clinical significance. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3

Thiamine transporter 1 — Clinical significance · splits 42 ⟂ 20

Thiamine transporter 1 — Structure · splits 44 ⟂ 18

Thiamine transporter 1 — Overview · splits 51 ⟂ 11

Thiamine transporter 1 — Function · splits 53 ⟂ 9

Thiamine transporter 1 — Interactions · splits 59 ⟂ 3

Map overview Semantic statistics

Thiamine transporter 1

Nodes62

Edges61

Triples73

Avg. degree1.97

Density0.032258

Components1

Source & methodology

TTTA analyzes the structure around Thiamine transporter 1 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Standards, Clinical significance & Structure, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Thiamine transporter 1 · EN edition · Analysis: TopicsToTalkAbout

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