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Thiamine: History & Applications

Thiamine, also known as thiamin and vitamin B1, is a vitamin – an essential micronutrient for humans and animals. It is found in food and commercially synthesized to be a dietary supplement or medication. Phosphorylated forms of thiamine are required for some metabolic reactions, including the breakdown of glucose and amino acids.

Language: English [EN]
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Thiamine topic overview

The analysis highlights History and Applications as prominent areas in the source structure around Thiamine.

Related topics
188
Source areas
9
Connected nodes
209
Extracted relationships
171
Concept neighborhoods
47
Bridge connections
209

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Synthesis · 43 topics
Biological functions · 32 topics
Overview · 25 topics
Definition · 22 topics
Absorption, metabolism and excretion · 21 topics
History · 21 topics
Deficiency · 9 topics
Medical uses · 8 topics
Dietary recommendations · 7 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3D model (JSmol)
cation: Interactive image
AHFS/Drugs.com
Monograph
ATC code
cation: A11DA01 (WHO)
Bioavailability
3.7% to 5.3% (Thiamine hydrochloride)
CAS Number
cation: 70-16-6 Y 67-03-8 (Cl−.HCl) · Cl− salt: 59-43-8 Y
ChEBI
cation: CHEBI:18385

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Definition

Deficiency

Biological functions

Medical uses

Dietary recommendations

Sources

Synthesis

Absorption, metabolism and excretion

History

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Thiamine connects Entity context

The extracted context around Thiamine shows recurring relationship patterns in the source. For example, Thiamine → Adequate Intake, AI, As, Authority, Average Requirements, Dietary Reference Values, EARs, EFSA, Estimated Average Requirements, For, Medicine, MJ, Population Reference Intakes, PRI, PRIs, RDA, RDAs, Recommended Dietary Allowances, The EARs, The European Food Safety Another extracted example is Thiamine → Barley Baron, He, However, Imperial Japanese Navy, In, Japanese, Not, Russo-Japanese War, Switching, Takaki, Takaki Kanehiro, Takaki's, The, The Navy. Use these groups to spot repeated connection types before inspecting the individual relationships.

Thiamine

Top relations

related to Dietary recommendations · 24
Thiamine → Adequate Intake, AI, As, Authority, Average Requirements, Dietary Reference Values, EARs, EFSA, Estimated Average Requirements, For, Medicine, MJ, Population Reference Intakes, PRI, PRIs, RDA, RDAs, Recommended Dietary Allowances, The EARs, The European Food Safety
related to history · 14
Thiamine → Barley Baron, He, However, Imperial Japanese Navy, In, Japanese, Not, Russo-Japanese War, Switching, Takaki, Takaki Kanehiro, Takaki's, The, The Navy
related to Thiamine pyrophosphate · 13
Thiamine → AMP, ATP, CoA, EC, Examples, However, Its, Present, ThDP, The, TPK1, TPP, UTP
related to Deficiency · 11
Thiamine → African, Also, HIV/AIDS, In Western, Korsakoff, Leigh's, Nigerian, Symptoms, Varying, Well-known, Wernicke
related to Biological functions · 10
Thiamine → AThDP, AThTP, Five, No, The, They, ThMP, ThTP, TPP, While
related to Industrial synthesis · 10
Thiamine → Co, Efficient, European Economic Area, Grewe, Hoffman La Roche, However, In, Merck, Rahway, REACH
related to Interference · 10
Thiamine → African, Anaphe, Consumption, From, In, Nigeria, Older, Sulfites, Thailand, The
related to Absorption, metabolism and excretion · 9
Thiamine → Active, At, In, Na, SLC19A2, SLC19A3, The, Two, Uptake
related to Food fortification · 9
Thiamine → An, As, February, For, Indian, North, Some, Sub-Saharan Africa, The
related to Definition · 7
Thiamine → B1, In, It, Maillard-type, Oxidation, The, TPP

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

also vitamin rice deficiency beriberi tpp food dietary present mg including countries may pyrophosphate acid known thiazole synthesis thmp reaction

Thiamine relationships Subject–Predicate–Object triples

TTTA extracted 171 structured relationships around Thiamine. Examples in this analysis include Thiamine → 3D model (JSmol) → cation: Interactive image and Thiamine → AHFS/Drugs.com → Monograph. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Thiamine3D model (JSmol)cation: Interactive image1.00infobox
ThiamineAHFS/Drugs.comMonograph1.00infobox
ThiamineATC codecation: A11DA01 (WHO)1.00infobox
ThiamineBioavailability3.7% to 5.3% (Thiamine hydrochloride)1.00infobox
ThiamineCAS Numbercation: 70-16-6 Y 67-03-8 (Cl−.HCl)1.00infobox
ThiamineCAS NumberCl− salt: 59-43-8 Y1.00infobox
ThiamineChEBIcation: CHEBI:183851.00infobox
ThiamineChEMBLcation: ChEMBL15471.00infobox
ThiamineChemSpidercation: 10981.00infobox
ThiamineCompTox Dashboard (EPA)cation: DTXSID502202511.00infobox
ThiamineDrug classVitamin1.00infobox
ThiamineDrugBankcation: DB001521.00infobox
ThiamineElimination half-life1–12 h1.00infobox
ThiamineFormulaC12H17N4OS+1.00infobox
ThiamineKEGGcation: C003781.00infobox
ThiamineLegal statusUS: OTC1.00infobox
ThiamineLicense dataUS DailyMed: Thiamine1.00infobox
ThiamineMolar mass265.36 g·mol−11.00infobox
ThiamineOther namesVitamin B1, aneurine, thiamin1.00infobox
ThiaminePronunciation/ˈθaɪ.əmɪn/ ⓘ THY-ə-min1.00infobox
ThiaminePubChem CIDcation: 11301.00infobox
ThiaminePubChem CIDCl− salt: 60421.00infobox
ThiamineRoutes of administrationBy mouth, intravenous, intramuscular1.00infobox
ThiamineUNIIcation: 4ABT0J945J1.00infobox
ThiamineUNIICl− salt: X66NSO3N35 Y1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Thiamine bring nearby vocabulary together. In this analysis, examples include Deficiency, Vitamin and Including. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Thiamine
    • Deficiency
    • Vitamin
    • Including
    • Tpp
    • Derivatives
    • Pyrophosphate
    • Food
    • Mg
    • Present
    • Required
    • Foods
    • Synthesis
  • thiamine
    • Deficiency
    • Vitamin
    • Including
    • Tpp
    • Derivatives
    • Pyrophosphate
    • Food
    • Mg
    • Present
    • Required
    • Foods
    • Synthesis
  • thiamine pyrophosphate
    • Derivatives
    • Coenzyme
    • Form
    • Tpp
    • Synthesis
    • Thmp
    • Deficiency
    • Reactions
    • Vitamins
    • Called
    • Thiazole
    • Vitamin
  • thiamine monophosphate
    • Deficiency
    • Vitamin
    • Including
    • Tpp
    • Derivatives
    • Pyrophosphate
    • Food
    • Mg
    • Present
    • Required
    • Foods
    • Synthesis
  • thiamine triphosphate
    • Deficiency
    • Vitamin
    • Including
    • Tpp
    • Derivatives
    • Pyrophosphate
    • Food
    • Mg
    • Present
    • Required
    • Foods
    • Synthesis
  • adenosine thiamine diphosphate
    • Deficiency
    • Vitamin
    • Including
    • Tpp
    • Derivatives
    • Pyrophosphate
    • Food
    • Mg
    • Present
    • Required
    • Foods
    • Synthesis
  • adenosine thiamine triphosphate
    • Deficiency
    • Vitamin
    • Including
    • Tpp
    • Derivatives
    • Pyrophosphate
    • Food
    • Mg
    • Present
    • Required
    • Foods
    • Synthesis
  • thiamine diphosphokinase
    • Deficiency
    • Vitamin
    • Including
    • Tpp
    • Derivatives
    • Pyrophosphate
    • Food
    • Mg
    • Present
    • Required
    • Foods
    • Synthesis

Connections between topic areas Semantic bridges

For Thiamine, one of the stronger structural bridges in this analysis connects Thiamine with Synthesis. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Thiamine — Synthesis · splits 166 ⟂ 44
Thiamine — Biological functions · splits 177 ⟂ 33
Thiamine — Overview · splits 184 ⟂ 26
Thiamine — Definition · splits 187 ⟂ 23
Thiamine — Absorption, metabolism and excretion · splits 188 ⟂ 22
Thiamine — History · splits 188 ⟂ 22
Thiamine — Sources · splits 198 ⟂ 12
Thiamine — Deficiency · splits 200 ⟂ 10
Thiamine — Medical uses · splits 201 ⟂ 9
Thiamine — Dietary recommendations · splits 202 ⟂ 8

Map overview Semantic statistics

Thiamine

Nodes210
Edges209
Triples171
Avg. degree1.99
Density0.009524
Components1

Source & methodology

TTTA analyzes the structure around Thiamine to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History & Applications, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Thiamine · EN edition · Analysis: TopicsToTalkAbout

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