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Endoglin: Art & Regions

Endoglin (ENG) is a type I membrane glycoprotein located on cell surfaces and is part of the TGF beta receptor complex. It is also commonly referred to as CD105, END, FLJ41744, HHT1, ORW and ORW1. It has a crucial role in angiogenesis, therefore, making it an important protein for tumor growth, survival and metastasis of cancer cells to other locations…

Language: English [EN]
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Endoglin topic overview

The analysis highlights Art and Regions as prominent areas in the source structure around Endoglin.

Related topics
31
Source areas
5
Connected nodes
36
Extracted relationships
193
Concept neighborhoods
13
Bridge connections
36

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Structure · 10 topics
Overview · 7 topics
Function · 6 topics
Interactions · 5 topics
Clinical significance · 3 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
ENG, Eng, AI528660, AI662476, CD105, Endo, S-endoglin, END, HHT1, ORW1, endoglin
Band
9q34.11 · 2 B|2 22.09 cM
Bgee
right lung · right auricle of heart · apex of heart · right lobe of thyroid gland · left ovary
BioGPS
More reference expression data
Chr.
Chromosome 9 (human) · Chromosome 2 (mouse)
Databases
NCBI: entry; OMA: entry

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Structure

Interactions

Function

Clinical significance

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Endoglin connects Entity context

The extracted context around Endoglin shows recurring relationship patterns in the source. For example, Endoglin → activin binding, angiogenesis, artery morphogenesis, atrial cardiac muscle tissue morphogenesis, atrioventricular canal morphogenesis, BMP binding, BMP signaling pathway, bone development, branching involved in blood vessel morphogenesis, cardiac atrium morphogenesis, cardiac ventricle morphogenesis, cell adhesion, cell chemotaxis, cell migration, cell migration involved in endocardial cushion formation, cell motility, cell surface, cellular response to mechanical stimulus, central nervous system vasculogenesis, detection of hypoxia Another extracted example is Endoglin → ankle joint, apex of heart, ascending aorta, cardiac muscle tissue of left ventricle, choroid plexus of fourth ventricle, Descending thoracic aorta, external carotid artery, Ileal epithelium, internal carotid artery, lactiferous gland, left ovary, right auricle of heart, right coronary artery, right lobe of thyroid gland, right lung, right lung lobe, right ovary, right ventricle, upper lobe of left lung. Use these groups to spot repeated connection types before inspecting the individual relationships.

Endoglin

Top relations

Gene ontology · 85
Endoglin → activin binding, angiogenesis, artery morphogenesis, atrial cardiac muscle tissue morphogenesis, atrioventricular canal morphogenesis, BMP binding, BMP signaling pathway, bone development, branching involved in blood vessel morphogenesis, cardiac atrium morphogenesis, cardiac ventricle morphogenesis, cell adhesion, cell chemotaxis, cell migration, cell migration involved in endocardial cushion formation, cell motility, cell surface, cellular response to mechanical stimulus, central nervous system vasculogenesis, detection of hypoxia
Bgee · 19
Endoglin → ankle joint, apex of heart, ascending aorta, cardiac muscle tissue of left ventricle, choroid plexus of fourth ventricle, Descending thoracic aorta, external carotid artery, Ileal epithelium, internal carotid artery, lactiferous gland, left ovary, right auricle of heart, right coronary artery, right lobe of thyroid gland, right lung, right lung lobe, right ovary, right ventricle, upper lobe of left lung
RNA expression pattern · 19
Endoglin → ankle joint, apex of heart, ascending aorta, cardiac muscle tissue of left ventricle, choroid plexus of fourth ventricle, Descending thoracic aorta, external carotid artery, Ileal epithelium, internal carotid artery, lactiferous gland, left ovary, right auricle of heart, right coronary artery, right lobe of thyroid gland, right lung, right lung lobe, right ovary, right ventricle, upper lobe of left lung
related to Structure · 12
Endoglin → BMP-9, However, It, L-endoglin, L-isoform, MMP-14, OR, S-endoglin, S-isoform, The, There, ZP
related to Function · 10
Endoglin → Beside TGF-beta, BMP-2, BMP-7, BMP-9, Experimental, It, Its, TGF-beta, TGF-beta1, TGF-beta3
related to Role in cancer · 10
Endoglin → Also, Being, Cancer, ECM, Hallmarks, However, In, TGF, The, The TGF
related to Interactions · 8
Endoglin → Furthermore, However, II, It, N-terminus, TGF, The, Unlike TGF
related to Clinical significance · 4
Endoglin → HHT, In, TGF, This
related to Gene and expression · 3
Endoglin → Other, The, This
Band · 2
Endoglin → 2 B|2 22.09 cM, 9q34.11

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

beta tgf receptor cells gene human expression bp cancer cell role binding extracellular complex growth band domain chr tumor chromosome

Endoglin relationships Subject–Predicate–Object triples

TTTA extracted 193 structured relationships around Endoglin. Examples in this analysis include Endoglin → Aliases → ENG, Eng, AI528660, AI662476, CD105, Endo, S-endoglin, END, HHT1, ORW1, endoglin and Endoglin → Band → 9q34.11. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
EndoglinAliasesENG, Eng, AI528660, AI662476, CD105, Endo, S-endoglin, END, HHT1, ORW1, endoglin1.00infobox
EndoglinBand9q34.111.00infobox
EndoglinBand2 B|2 22.09 cM1.00infobox
EndoglinBgeeright lung1.00infobox
EndoglinBgeeright auricle of heart1.00infobox
EndoglinBgeeapex of heart1.00infobox
EndoglinBgeeright lobe of thyroid gland1.00infobox
EndoglinBgeeleft ovary1.00infobox
EndoglinBgeeright ovary1.00infobox
EndoglinBgeeright coronary artery1.00infobox
EndoglinBgeeupper lobe of left lung1.00infobox
EndoglinBgeeascending aorta1.00infobox
EndoglinBgeeDescending thoracic aorta1.00infobox
EndoglinBgeelactiferous gland1.00infobox
EndoglinBgeeankle joint1.00infobox
EndoglinBgeechoroid plexus of fourth ventricle1.00infobox
EndoglinBgeecardiac muscle tissue of left ventricle1.00infobox
EndoglinBgeeright lung lobe1.00infobox
EndoglinBgeeexternal carotid artery1.00infobox
EndoglinBgeeIleal epithelium1.00infobox
EndoglinBgeeinternal carotid artery1.00infobox
EndoglinBgeeright ventricle1.00infobox
EndoglinBioGPSMore reference expression data1.00infobox
EndoglinChr.Chromosome 9 (human)1.00infobox
EndoglinChr.Chromosome 2 (mouse)1.00infobox
EndoglinDatabasesNCBI: entry; OMA: entry1.00infobox
EndoglinEnd127,854,658 bp1.00infobox
EndoglinEnd32,572,681 bp1.00infobox
EndoglinEnsemblENSG000001069911.00infobox
EndoglinEntrez20221.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Endoglin bring nearby vocabulary together. In this analysis, examples include Beta, Tgf and Receptor. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Endoglin
    • Beta
    • Tgf
    • Receptor
    • Cell
    • Role
    • Expression
    • Cells
    • High
    • Migration
    • Complex
    • Gene
    • Binding
  • endoglin
    • Beta
    • Tgf
    • Receptor
    • Cell
    • Role
    • Expression
    • Cells
    • High
    • Migration
    • Complex
    • Gene
    • Binding
  • cell
    • Angiogenesis
    • Migration
    • Signaling
    • Growth
    • Eng
    • Cellular
    • Membrane
    • Beta
    • Endothelial
    • Receptor
    • Complex
    • Binding
  • tgf beta receptor
    • Tgf
    • Receptor
    • Endoglin
    • Complex
    • Bind
    • High
    • Cellular
    • Migration
    • Tail
    • Cell
    • Growth
    • Cytoplasmic
  • angiogenesis
    • Growth
    • Cell
    • Cellular
    • Migration
    • Protein
    • Signaling
    • Tumor
    • Role
    • Cancer
    • Eng
    • Location
    • Beta
  • tgf beta receptor 3
    • Tgf
    • Receptor
    • Endoglin
    • Complex
    • Bind
    • High
    • Cellular
    • Migration
    • Tail
    • Cell
    • Growth
    • Cytoplasmic
  • tgf beta receptor 1
    • Tgf
    • Receptor
    • Endoglin
    • Complex
    • Bind
    • High
    • Cellular
    • Migration
    • Tail
    • Cell
    • Growth
    • Cytoplasmic
  • tgf beta receptor 2
    • Tgf
    • Receptor
    • Endoglin
    • Complex
    • Bind
    • High
    • Cellular
    • Migration
    • Tail
    • Cell
    • Growth
    • Cytoplasmic

Connections between topic areas Semantic bridges

For Endoglin, one of the stronger structural bridges in this analysis connects Endoglin with Structure. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
EndoglinStructure · splits 26 ⟂ 11
EndoglinOverview · splits 29 ⟂ 8
EndoglinFunction · splits 30 ⟂ 7
EndoglinInteractions · splits 31 ⟂ 6
EndoglinClinical significance · splits 33 ⟂ 4

Map overview Semantic statistics

Endoglin

Nodes37
Edges36
Triples193
Avg. degree1.95
Density0.054054
Components1

Source & methodology

TTTA analyzes the structure around Endoglin to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Art & Regions, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Endoglin · EN edition · Analysis: TopicsToTalkAbout

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