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SGLT2 inhibitor

SGLT2 inhibitors (also called gliflozins or flozins) are a class of medications that inhibit sodium-glucose transport proteins in the nephron (the functional units of the kidney), unlike SGLT1 inhibitors that perform a similar function in the intestinal mucosa. The foremost metabolic effect of this is to inhibit reabsorption of glucose in the kidney and…

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SGLT2 inhibitor

Nodes139
Edges138
Triples113
Avg. degree1.99
Density0.014388
Components1

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SGLT2 inhibitor

Top relations

related to Members · 61
SGLT2 inhibitor → Apleway, Approved, Astellas Pharma Inc, August, Bexagliflozin, Boehringer Ingelheim, Boehringer Ingelheim Animal Health, Brenzavvy, Canagliflozin, China, Daewoong Pharmaceutical, Dapagliflozin, Deberza, December, Drug Administration, Ecuador, Empagliflozin, Enavogliflozin, Ertugliflozin, EU
related to External links · 17
SGLT2 inhibitor → Archived, December, Drug Administration, FDA, FDA Drug Safety Communication, Food, Interim, Invokamet, Invokamet XR, Invokana, January, May, November, October, September, SGLT2, Warning
has effect · 11
SGLT2 inhibitor → By, Canagliflozin, DKA, FDA, Genital, In, In May, SGLT2, Symptoms, They, To
related to Medical uses · 8
SGLT2 inhibitor → ADA, American Diabetes Association, Another, DPP-4, GLP-1, SGLT-2, SGLT2, The
related to Interactions · 6
SGLT2 inhibitor → For, Gliflozins, Interactions, It, P450, SGLT2
related to Research · 4
SGLT2 inhibitor → Gliflozins, Pleiotropic, SGLT2, The

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Important terminology

sglt2 diabetes inhibitors glucose fda approved gliflozins dapagliflozin canagliflozin risk blood type sugar kidney drug medications empagliflozin patients brand class

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
sulfonylureasinstance ofUsing gliflozins in combination therapy with metformin can lower the risk of hypoglycemia compared to other type 2 diabetes treatments0.80text
insulin.Increased risk of lower limb amputation is associated with canagliflozininstance ofUsing gliflozins in combination therapy with metformin can lower the risk of hypoglycemia compared to other type 2 diabetes treatments0.80text
but further data is needed to confirm this risk associated with different gliflozinsinstance ofUsing gliflozins in combination therapy with metformin can lower the risk of hypoglycemia compared to other type 2 diabetes treatments0.80text
natriuresisinstance ofPleiotropic effects of this class have been attributed to a variety of its pharmacodynamic actions0.80text
hemoconcentrationinstance ofPleiotropic effects of this class have been attributed to a variety of its pharmacodynamic actions0.80text
deactivation of renininstance ofPleiotropic effects of this class have been attributed to a variety of its pharmacodynamic actions0.80text
SGLT2 inhibitorhas effectGenital0.60section
SGLT2 inhibitorhas effectIn0.60section
SGLT2 inhibitorhas effectIn May0.60section
SGLT2 inhibitorhas effectFDA0.60section
SGLT2 inhibitorhas effectDKA0.60section
SGLT2 inhibitorhas effectBy0.60section

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