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PEDF

Pigment epithelium-derived factor (PEDF) also known as serpin F1 (SERPINF1), is a multifunctional secreted protein that has anti-angiogenic, anti-tumorigenic, and neurotrophic functions. Found in vertebrates, this 50 kDa protein is being researched as a therapeutic candidate for treatment of such conditions as choroidal neovascularization, heart disease…

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Aliases
SERPINF1, EPC-1, OI12, OI6, PEDF, PIG35, serpin family F member 1
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1IMV
Band
17p13.3 · 11|11 B5
Bgee
retinal pigment epithelium · pericardium · canal of the cervix · left uterine tube · gallbladder
BioGPS
More reference expression data
Chr.
Chromosome 17 (human) · Chromosome 11 (mouse)

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Gene

Protein

Signaling

Function

Clinical significance

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Map overview Semantic statistics

PEDF

Nodes69
Edges68
Triples158
Avg. degree1.97
Density0.028986
Components1

How this topic connects Entity context

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PEDF

Top relations

Gene ontology · 35
PEDF → ageing, axon, axon hillock, basement membrane, cell population proliferation, cellular response to cobalt ion, cellular response to dexamethasone stimulus, cellular response to glucose stimulus, cellular response to retinoic acid, collagen-containing extracellular matrix, extracellular exosome, extracellular matrix, extracellular region, extracellular space, kidney development, melanosome, multicellular organism development, negative regulation of angiogenesis, negative regulation of endopeptidase activity, negative regulation of endothelial cell migration
Bgee · 20
PEDF → ankle, aortic valve, ascending aorta, body of femur, calvaria, canal of the cervix, cervix, gallbladder, gastric mucosa, left lobe of liver, left uterine tube, lip, molar, pericardium, periodontal fiber, retinal pigment epithelium, right lobe of liver, right ovary, stroma of bone marrow, vena cava
RNA expression pattern · 20
PEDF → ankle, aortic valve, ascending aorta, body of femur, calvaria, canal of the cervix, cervix, gallbladder, gastric mucosa, left lobe of liver, left uterine tube, lip, molar, pericardium, periodontal fiber, retinal pigment epithelium, right lobe of liver, right ovary, stroma of bone marrow, vena cava
related to Protein · 12
PEDF → BLAST, C-terminus, In, Near, NLS, One, RCL, The, The N-terminus, The PEDF, They, This
related to Signaling · 11
PEDF → A2, Hypoxia, In, K5, Laminin, MMPs, PEDF-R, Secreted PEDF, This, VEGF, VEGFR-1
related to Discovery · 9
PEDF → Joyce Tombran-Tink, Lincoln Johnson, Pigment, RPE, RPE-54, Soon, They, This, Upon
related to Function · 8
PEDF → Antiangiogenic, Endothelial, FAS/FASL, MAPK, The, VEGF, VEGFR-1, VEGFR-2
related to Gene · 8
PEDF → CHOP, HNF4, Immediately, Sea, SerpinF2, The, The PEDF, USF
related to Glaucoma and zinc-mediated modulation · 6
PEDF → In, PEDF-R/PNPLA2, PEDF’s, Recent, This, Together
related to Clinical significance · 3
PEDF → As, Molecules, VEGF

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Important terminology

protein gene human cell bp chromosome neurotrophic retinal residues serpinf1 pigment neovascularization chr cancer band function cells antiangiogenic also factor

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
PEDFAliasesSERPINF1, EPC-1, OI12, OI6, PEDF, PIG35, serpin family F member 11.00infobox
PEDFAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1IMV1.00infobox
PEDFBand17p13.31.00infobox
PEDFBand11|11 B51.00infobox
PEDFBgeeretinal pigment epithelium1.00infobox
PEDFBgeepericardium1.00infobox
PEDFBgeecanal of the cervix1.00infobox
PEDFBgeeleft uterine tube1.00infobox
PEDFBgeegallbladder1.00infobox
PEDFBgeeperiodontal fiber1.00infobox
PEDFBgeevena cava1.00infobox
PEDFBgeeright ovary1.00infobox
PEDFBgeeright lobe of liver1.00infobox
PEDFBgeegastric mucosa1.00infobox
PEDFBgeecalvaria1.00infobox
PEDFBgeemolar1.00infobox
PEDFBgeebody of femur1.00infobox
PEDFBgeeankle1.00infobox
PEDFBgeeleft lobe of liver1.00infobox
PEDFBgeeaortic valve1.00infobox
PEDFBgeeascending aorta1.00infobox
PEDFBgeestroma of bone marrow1.00infobox
PEDFBgeelip1.00infobox
PEDFBgeecervix1.00infobox
PEDFBioGPSMore reference expression data1.00infobox
PEDFChr.Chromosome 17 (human)1.00infobox
PEDFChr.Chromosome 11 (mouse)1.00infobox
PEDFDatabasesNCBI: entry; OMA: entry1.00infobox
PEDFEnd1,777,565 bp1.00infobox
PEDFEnd75,313,527 bp1.00infobox

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