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Progesterone (P4), sold under the brand name Prometrium among others, is a medication and naturally occurring steroid hormone. It is a progestogen and is used in combination with estrogens mainly in hormone therapy for menopausal symptoms, and low sex hormone levels in women, as well as gender affirming therapy in transgender women. It is also used in…
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progesterone oral vaginal brand women effects breast also marketed name use intramuscular estrogen injection available used may estradiol found first
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| Progesterone (medication) | 3D model (JSmol) | Interactive image | 1.00 | infobox |
| Progesterone (medication) | AHFS/Drugs.com | Monograph | 1.00 | infobox |
| Progesterone (medication) | ATC code | G03DA04 (WHO) | 1.00 | infobox |
| Progesterone (medication) | Bioavailability | Oral: <2.4% Vaginal (micronized insert): 4–8% | 1.00 | infobox |
| Progesterone (medication) | CAS Number | 57-83-0 Y | 1.00 | infobox |
| Progesterone (medication) | ChEBI | CHEBI:17026 Y | 1.00 | infobox |
| Progesterone (medication) | ChEMBL | ChEMBL103 Y | 1.00 | infobox |
| Progesterone (medication) | ChemSpider | 5773 Y | 1.00 | infobox |
| Progesterone (medication) | Drug class | Progestogen; Antimineralocorticoid; Neurosteroid | 1.00 | infobox |
| Progesterone (medication) | DrugBank | DB00396 Y | 1.00 | infobox |
| Progesterone (medication) | Elimination half-life | • Oral: 5 hours (with food) * Sublingual: 6–7 hours • Vaginal: 14–50 hours • Topical: 30–40 hours • IM: 20–28 hours • SC: 13–18 hours • IVTooltip Intravenous injection: 3–90 min… | 1.00 | infobox |
| Progesterone (medication) | Excretion | Bile and urine | 1.00 | infobox |
| Progesterone (medication) | Formula | C21H30O2 | 1.00 | infobox |
| Progesterone (medication) | IUPHAR/BPS | 2377 | 1.00 | infobox |
| Progesterone (medication) | KEGG | D00066 Y | 1.00 | infobox |
| Progesterone (medication) | Legal status | AU: S4 (Prescription only) | 1.00 | infobox |
| Progesterone (medication) | Legal status | CA: ℞-only | 1.00 | infobox |
| Progesterone (medication) | Legal status | In general: ℞ (Prescription only) | 1.00 | infobox |
| Progesterone (medication) | MedlinePlus | a604017 | 1.00 | infobox |
| Progesterone (medication) | Melting point | 126 °C (259 °F) | 1.00 | infobox |
| Progesterone (medication) | Metabolism | Mainly liver: • 5α- and 5β-reductase • 3α-Tooltip 3α-Hydroxysteroid dehydrogenase and 3β-HSDTooltip 3β-Hydroxysteroid dehydrogenase • 20α-Tooltip 20α-Hydroxysteroid dehydrogenas… | 1.00 | infobox |
| Progesterone (medication) | Metabolites | • Dihydroprogesterones • Pregnanolones • Pregnanediols • 20α-Hydroxyprogesterone • 17α-Hydroxyprogesterone • Pregnanetriols • 11-Deoxycorticosterone (and glucuronide/sulfate con… | 1.00 | infobox |
| Progesterone (medication) | Molar mass | 314.469 g·mol−1 | 1.00 | infobox |
| Progesterone (medication) | Other names | P4; Pregnenedione; Pregn-4-ene-3,20-dione | 1.00 | infobox |
| Progesterone (medication) | Protein binding | 98–99%: • Albumin: 80% • CBGTooltip Corticosteroid-binding globulin: 18% • SHBGTooltip Sex hormone-binding globulin: <1% • Free: 1–2% | 1.00 | infobox |
| Progesterone (medication) | PubChem CID | 5994 | 1.00 | infobox |
| Progesterone (medication) | Routes of administration | By mouth, sublingual, topical, vaginal, rectal, intramuscular, subcutaneous, intrauterine | 1.00 | infobox |
| Progesterone (medication) | Specific rotation | [α]D25 = +172 to +182° (2% in dioxane, β-form) | 1.00 | infobox |
| Progesterone (medication) | Trade names | Prometrium, Utrogestan, Endometrin, others | 1.00 | infobox |
| Progesterone (medication) | UNII | 4G7DS2Q64Y | 1.00 | infobox |
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