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PIEZO1

Piezo-type mechanosensitive ion channel component 1 is a protein that in humans is encoded by the PIEZO1 gene. PIEZO1 is a large mechanosensitive ion channel protein that forms a homotrimeric complex with a distinctive three-bladed, propeller-shaped architecture. Each subunit of PIEZO1 contains between 30 and 40 transmembrane domains. The protein…

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Aliases
PIEZO1, DHS, FAM38A, Mib, LMPH3, piezo type mechanosensitive ion channel component 1, LMPHM6
Band
16q24.3 · 8|8 E1
Bgee
muscle layer of sigmoid colon · upper lobe of left lung · granulocyte · spleen · subcutaneous adipose tissue
BioGPS
n/a
Chr.
Chromosome 16 (human) · Chromosome 8 (mouse)
Databases
NCBI: entry; OMA: entry

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PIEZO1

Nodes64
Edges63
Triples139
Avg. degree1.97
Density0.03125
Components1

How this topic connects Entity context

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PIEZO1

Top relations

Bgee · 20
PIEZO1 → calvaria, ciliary body, endothelial cell of lymphatic vessel, external carotid artery, gastric mucosa, granulocyte, internal carotid artery, iris, left uterine tube, medullary collecting duct, muscle layer of sigmoid colon, otic vesicle, prostate, right lung, skin of leg, spleen, stroma of bone marrow, subcutaneous adipose tissue, upper lobe of left lung, vestibular membrane of cochlear duct
Gene ontology · 20
PIEZO1 → cation channel activity, cation transmembrane transport, cation transport, cell projection, cellular response to mechanical stimulus, detection of mechanical stimulus, endoplasmic reticulum, endoplasmic reticulum membrane, endoplasmic reticulum-Golgi intermediate compartment membrane, integral component of membrane, ion transmembrane transport, ion transport, lamellipodium membrane, mechanosensitive ion channel activity, membrane, plasma membrane, positive regulation of cell-cell adhesion mediated by integrin, positive regulation of integrin activation, regulation of membrane potential, transmembrane transport
RNA expression pattern · 20
PIEZO1 → calvaria, ciliary body, endothelial cell of lymphatic vessel, external carotid artery, gastric mucosa, granulocyte, internal carotid artery, iris, left uterine tube, medullary collecting duct, muscle layer of sigmoid colon, otic vesicle, prostate, right lung, skin of leg, spleen, stroma of bone marrow, subcutaneous adipose tissue, upper lobe of left lung, vestibular membrane of cochlear duct
related to Structure · 14
PIEZO1 → As, Drosophila, In, InterPro, IPR027272, It, PDB, Piezo, Piezo2, TCDB, They, This, Typically, When
related to Cell cycle regulation and migration · 12
PIEZO1 → B1, Beginning, DRG, E-cadherin, ERK1/2, In, MAPK, PDLCs, Piezo1-mediated, The, The MAPK, These
related to Cell volume regulation · 7
PIEZO1 → It, Kca, Mechanotransduction, Potassium, RVD, This, VRACs
related to Conformational signaling · 6
PIEZO1 → Activation, Interactions, Research, The, This, TREK1
related to Clinical significance · 5
PIEZO1 → An, E756del, Plasmodium, RBCs, This
related to Feedback mechanisms · 5
PIEZO1 → Increased, PIP2, PLC, The, This
is a · 3
PIEZO1 → defining characteristic, large mechanosensitive ion channel protein that forms a homotrimeric complex with a distinctive three-bladed, pore-forming subunit of a mechanosensitive channel

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Important terminology

protein cells ion channel mechanosensitive channels gene cell bp membrane activation chr human band signaling volume mechanical cellular transmembrane homeostasis

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
PIEZO1AliasesPIEZO1, DHS, FAM38A, Mib, LMPH3, piezo type mechanosensitive ion channel component 1, LMPHM61.00infobox
PIEZO1Band16q24.31.00infobox
PIEZO1Band8|8 E11.00infobox
PIEZO1Bgeemuscle layer of sigmoid colon1.00infobox
PIEZO1Bgeeupper lobe of left lung1.00infobox
PIEZO1Bgeegranulocyte1.00infobox
PIEZO1Bgeespleen1.00infobox
PIEZO1Bgeesubcutaneous adipose tissue1.00infobox
PIEZO1Bgeeright lung1.00infobox
PIEZO1Bgeeprostate1.00infobox
PIEZO1Bgeegastric mucosa1.00infobox
PIEZO1Bgeeskin of leg1.00infobox
PIEZO1Bgeeleft uterine tube1.00infobox
PIEZO1Bgeeendothelial cell of lymphatic vessel1.00infobox
PIEZO1Bgeevestibular membrane of cochlear duct1.00infobox
PIEZO1Bgeeinternal carotid artery1.00infobox
PIEZO1Bgeeexternal carotid artery1.00infobox
PIEZO1Bgeestroma of bone marrow1.00infobox
PIEZO1Bgeeotic vesicle1.00infobox
PIEZO1Bgeeiris1.00infobox
PIEZO1Bgeeciliary body1.00infobox
PIEZO1Bgeemedullary collecting duct1.00infobox
PIEZO1Bgeecalvaria1.00infobox
PIEZO1BioGPSn/a1.00infobox
PIEZO1Chr.Chromosome 16 (human)1.00infobox
PIEZO1Chr.Chromosome 8 (mouse)1.00infobox
PIEZO1DatabasesNCBI: entry; OMA: entry1.00infobox
PIEZO1End88,785,220 bp1.00infobox
PIEZO1End123,278,068 bp1.00infobox
PIEZO1EnsemblENSG000001033351.00infobox

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