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PIEZO1: Measurement, Function & Clinical significance

Piezo-type mechanosensitive ion channel component 1 is a protein that in humans is encoded by the PIEZO1 gene. PIEZO1 is a large mechanosensitive ion channel protein that forms a homotrimeric complex with a distinctive three-bladed, propeller-shaped architecture. Each subunit of PIEZO1 contains between 30 and 40 transmembrane domains. The protein…

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PIEZO1 topic overview

The analysis highlights Measurement, Function and Clinical significance as prominent areas in the source structure around PIEZO1.

Related topics
56
Source areas
7
Connected nodes
63
Extracted relationships
139
Concept neighborhoods
21
Bridge connections
63

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Function · 20 topics
Clinical significance · 15 topics
Overview · 8 topics
Structure · 6 topics
Regulation · 4 topics
Ligands · 2 topics
Tissue distribution · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
PIEZO1, DHS, FAM38A, Mib, LMPH3, piezo type mechanosensitive ion channel component 1, LMPHM6
Band
16q24.3 · 8|8 E1
Bgee
muscle layer of sigmoid colon · upper lobe of left lung · granulocyte · spleen · subcutaneous adipose tissue
BioGPS
n/a
Chr.
Chromosome 16 (human) · Chromosome 8 (mouse)
Databases
NCBI: entry; OMA: entry

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Structure

Function

Regulation

Tissue distribution

Clinical significance

Ligands

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How PIEZO1 connects Entity context

The extracted context around PIEZO1 shows recurring relationship patterns in the source. For example, PIEZO1 → calvaria, ciliary body, endothelial cell of lymphatic vessel, external carotid artery, gastric mucosa, granulocyte, internal carotid artery, iris, left uterine tube, medullary collecting duct, muscle layer of sigmoid colon, otic vesicle, prostate, right lung, skin of leg, spleen, stroma of bone marrow, subcutaneous adipose tissue, upper lobe of left lung, vestibular membrane of cochlear duct Another extracted example is PIEZO1 → cation channel activity, cation transmembrane transport, cation transport, cell projection, cellular response to mechanical stimulus, detection of mechanical stimulus, endoplasmic reticulum, endoplasmic reticulum membrane, endoplasmic reticulum-Golgi intermediate compartment membrane, integral component of membrane, ion transmembrane transport, ion transport, lamellipodium membrane, mechanosensitive ion channel activity, membrane, plasma membrane, positive regulation of cell-cell adhesion mediated by integrin, positive regulation of integrin activation, regulation of membrane potential, transmembrane transport. Use these groups to spot repeated connection types before inspecting the individual relationships.

PIEZO1

Top relations

Bgee · 20
PIEZO1 → calvaria, ciliary body, endothelial cell of lymphatic vessel, external carotid artery, gastric mucosa, granulocyte, internal carotid artery, iris, left uterine tube, medullary collecting duct, muscle layer of sigmoid colon, otic vesicle, prostate, right lung, skin of leg, spleen, stroma of bone marrow, subcutaneous adipose tissue, upper lobe of left lung, vestibular membrane of cochlear duct
Gene ontology · 20
PIEZO1 → cation channel activity, cation transmembrane transport, cation transport, cell projection, cellular response to mechanical stimulus, detection of mechanical stimulus, endoplasmic reticulum, endoplasmic reticulum membrane, endoplasmic reticulum-Golgi intermediate compartment membrane, integral component of membrane, ion transmembrane transport, ion transport, lamellipodium membrane, mechanosensitive ion channel activity, membrane, plasma membrane, positive regulation of cell-cell adhesion mediated by integrin, positive regulation of integrin activation, regulation of membrane potential, transmembrane transport
RNA expression pattern · 20
PIEZO1 → calvaria, ciliary body, endothelial cell of lymphatic vessel, external carotid artery, gastric mucosa, granulocyte, internal carotid artery, iris, left uterine tube, medullary collecting duct, muscle layer of sigmoid colon, otic vesicle, prostate, right lung, skin of leg, spleen, stroma of bone marrow, subcutaneous adipose tissue, upper lobe of left lung, vestibular membrane of cochlear duct
related to Structure · 14
PIEZO1 → As, Drosophila, In, InterPro, IPR027272, It, PDB, Piezo, Piezo2, TCDB, They, This, Typically, When
related to Cell cycle regulation and migration · 12
PIEZO1 → B1, Beginning, DRG, E-cadherin, ERK1/2, In, MAPK, PDLCs, Piezo1-mediated, The, The MAPK, These
related to Cell volume regulation · 7
PIEZO1 → It, Kca, Mechanotransduction, Potassium, RVD, This, VRACs
related to Conformational signaling · 6
PIEZO1 → Activation, Interactions, Research, The, This, TREK1
related to Clinical significance · 5
PIEZO1 → An, E756del, Plasmodium, RBCs, This
related to Feedback mechanisms · 5
PIEZO1 → Increased, PIP2, PLC, The, This
is a · 3
PIEZO1 → defining characteristic, large mechanosensitive ion channel protein that forms a homotrimeric complex with a distinctive three-bladed, pore-forming subunit of a mechanosensitive channel

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

protein cells ion channel mechanosensitive channels gene cell bp membrane activation chr human band signaling volume mechanical cellular transmembrane homeostasis

PIEZO1 relationships Subject–Predicate–Object triples

TTTA extracted 139 structured relationships around PIEZO1. Examples in this analysis include PIEZO1 → Aliases → PIEZO1, DHS, FAM38A, Mib, LMPH3, piezo type mechanosensitive ion channel component 1, LMPHM6 and PIEZO1 → Band → 16q24.3. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
PIEZO1AliasesPIEZO1, DHS, FAM38A, Mib, LMPH3, piezo type mechanosensitive ion channel component 1, LMPHM61.00infobox
PIEZO1Band16q24.31.00infobox
PIEZO1Band8|8 E11.00infobox
PIEZO1Bgeemuscle layer of sigmoid colon1.00infobox
PIEZO1Bgeeupper lobe of left lung1.00infobox
PIEZO1Bgeegranulocyte1.00infobox
PIEZO1Bgeespleen1.00infobox
PIEZO1Bgeesubcutaneous adipose tissue1.00infobox
PIEZO1Bgeeright lung1.00infobox
PIEZO1Bgeeprostate1.00infobox
PIEZO1Bgeegastric mucosa1.00infobox
PIEZO1Bgeeskin of leg1.00infobox
PIEZO1Bgeeleft uterine tube1.00infobox
PIEZO1Bgeeendothelial cell of lymphatic vessel1.00infobox
PIEZO1Bgeevestibular membrane of cochlear duct1.00infobox
PIEZO1Bgeeinternal carotid artery1.00infobox
PIEZO1Bgeeexternal carotid artery1.00infobox
PIEZO1Bgeestroma of bone marrow1.00infobox
PIEZO1Bgeeotic vesicle1.00infobox
PIEZO1Bgeeiris1.00infobox
PIEZO1Bgeeciliary body1.00infobox
PIEZO1Bgeemedullary collecting duct1.00infobox
PIEZO1Bgeecalvaria1.00infobox
PIEZO1BioGPSn/a1.00infobox
PIEZO1Chr.Chromosome 16 (human)1.00infobox
PIEZO1Chr.Chromosome 8 (mouse)1.00infobox
PIEZO1DatabasesNCBI: entry; OMA: entry1.00infobox
PIEZO1End88,785,220 bp1.00infobox
PIEZO1End123,278,068 bp1.00infobox
PIEZO1EnsemblENSG000001033351.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around PIEZO1 bring nearby vocabulary together. In this analysis, examples include Cells, Channels and Function. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • PIEZO1
    • Cells
    • Channels
    • Function
    • Role
    • Activation
    • Cell
    • Activity
    • Expressed
    • Cellular
    • Membrane
    • Protein
    • Piezo2
  • piezo1
    • Cells
    • Channels
    • Function
    • Role
    • Activation
    • Cell
    • Activity
    • Expressed
    • Cellular
    • Membrane
    • Protein
    • Piezo2
  • mechanosensitive ion channel
    • Mechanosensitive
    • Channel
    • Ion
    • Component
    • Channels
    • Protein
    • Gene
    • Location
    • Piezo2
    • Regulation
    • Signaling
    • Chromosome
  • transmembrane domains
    • Component
    • Location
    • Mouse
    • Piezo2
    • Pore
    • Regulation
    • Activity
    • Band
    • Chromosome
    • Expressed
    • Human
    • Skin
  • cation channel
    • Mechanosensitive
    • Ion
    • Component
    • Gene
    • Protein
    • Location
    • Regulation
    • Chromosome
    • Human
    • Piezo
    • Tissue
    • Bp
  • ion channels
    • Mechanosensitive
    • Channel
    • Component
    • Protein
    • Channels
    • Ion
    • Gene
    • Signaling
    • Location
    • Piezo2
    • Regulation
    • Activity
  • volume-regulated anion channels
    • Mechanosensitive
    • Ion
    • Piezo2
    • Function
    • Membrane
    • Piezo1
    • Protein
    • Cells
    • Component
    • Location
    • Mouse
    • Regulation
  • membrane potential
    • Activity
    • Signaling
    • Activation
    • Channels
    • Location
    • Mouse
    • Piezo2
    • Regulation
    • Tension
    • Band
    • Chromosome
    • Expressed

Connections between topic areas Semantic bridges

For PIEZO1, one of the stronger structural bridges in this analysis connects PIEZO1 with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
PIEZO1Function · splits 43 ⟂ 21
PIEZO1Clinical significance · splits 48 ⟂ 16
PIEZO1Overview · splits 55 ⟂ 9
PIEZO1Structure · splits 57 ⟂ 7
PIEZO1Regulation · splits 59 ⟂ 5
PIEZO1Ligands · splits 61 ⟂ 3

Map overview Semantic statistics

PIEZO1

Nodes64
Edges63
Triples139
Avg. degree1.97
Density0.03125
Components1

Source & methodology

TTTA analyzes the structure around PIEZO1 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Measurement, Function & Clinical significance, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — PIEZO1 · EN edition · Analysis: TopicsToTalkAbout

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