PEDF

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PEDF topic overview

The analysis highlights Art and Regions as prominent areas in the source structure around PEDF.

Related topics: 61
Source areas: 7
Connected nodes: 68
Extracted relationships: 158
Concept neighborhoods: 24
Bridge connections: 68

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Signaling · 18 topics

Overview · 9 topics

Function · 8 topics

Gene · 8 topics

Clinical significance · 7 topics

Discovery · 6 topics

Protein · 5 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases: SERPINF1, EPC-1, OI12, OI6, PEDF, PIG35, serpin family F member 1
Available structures: Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1IMV
Band: 17p13.3 · 11|11 B5
Bgee: retinal pigment epithelium · pericardium · canal of the cervix · left uterine tube · gallbladder
BioGPS: More reference expression data
Chr.: Chromosome 17 (human) · Chromosome 11 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Discovery

Retinal cell Retina
Retinal pigmented epithelium
Neuronal Neuron
Sequenced Protein sequence
Library Library (biology)
Serpin

Gene

Clinical significance

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How PEDF connects Entity context

The extracted context around PEDF shows recurring relationship patterns in the source. For example, PEDF → ageing, axon, axon hillock, basement membrane, cell population proliferation, cellular response to cobalt ion, cellular response to dexamethasone stimulus, cellular response to glucose stimulus, cellular response to retinoic acid, collagen-containing extracellular matrix, extracellular exosome, extracellular matrix, extracellular region, extracellular space, kidney development, melanosome, multicellular organism development, negative regulation of angiogenesis, negative regulation of endopeptidase activity, negative regulation of endothelial cell migration Another extracted example is PEDF → ankle, aortic valve, ascending aorta, body of femur, calvaria, canal of the cervix, cervix, gallbladder, gastric mucosa, left lobe of liver, left uterine tube, lip, molar, pericardium, periodontal fiber, retinal pigment epithelium, right lobe of liver, right ovary, stroma of bone marrow, vena cava. Use these groups to spot repeated connection types before inspecting the individual relationships.

Top relations

Gene ontology · 35

PEDF → ageing, axon, axon hillock, basement membrane, cell population proliferation, cellular response to cobalt ion, cellular response to dexamethasone stimulus, cellular response to glucose stimulus, cellular response to retinoic acid, collagen-containing extracellular matrix, extracellular exosome, extracellular matrix, extracellular region, extracellular space, kidney development, melanosome, multicellular organism development, negative regulation of angiogenesis, negative regulation of endopeptidase activity, negative regulation of endothelial cell migration

Bgee · 20

PEDF → ankle, aortic valve, ascending aorta, body of femur, calvaria, canal of the cervix, cervix, gallbladder, gastric mucosa, left lobe of liver, left uterine tube, lip, molar, pericardium, periodontal fiber, retinal pigment epithelium, right lobe of liver, right ovary, stroma of bone marrow, vena cava

RNA expression pattern · 20

related to Protein · 12

PEDF → BLAST, C-terminus, In, Near, NLS, One, RCL, The, The N-terminus, The PEDF, They, This

related to Signaling · 11

PEDF → A2, Hypoxia, In, K5, Laminin, MMPs, PEDF-R, Secreted PEDF, This, VEGF, VEGFR-1

related to Discovery · 9

PEDF → Joyce Tombran-Tink, Lincoln Johnson, Pigment, RPE, RPE-54, Soon, They, This, Upon

related to Function · 8

PEDF → Antiangiogenic, Endothelial, FAS/FASL, MAPK, The, VEGF, VEGFR-1, VEGFR-2

related to Gene · 8

PEDF → CHOP, HNF4, Immediately, Sea, SerpinF2, The, The PEDF, USF

related to Glaucoma and zinc-mediated modulation · 6

PEDF → In, PEDF-R/PNPLA2, PEDF’s, Recent, This, Together

related to Clinical significance · 3

PEDF → As, Molecules, VEGF

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

protein gene human cell bp chromosome neurotrophic retinal residues serpinf1 pigment neovascularization chr cancer band function cells antiangiogenic also factor

PEDF relationships Subject–Predicate–Object triples

TTTA extracted 158 structured relationships around PEDF. Examples in this analysis include PEDF → Aliases → SERPINF1, EPC-1, OI12, OI6, PEDF, PIG35, serpin family F member 1 and PEDF → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1IMV. The table shows each extracted connection, where it came from and its confidence.

Subject	Predicate	Object	Confidence	Src
PEDF	Aliases	SERPINF1, EPC-1, OI12, OI6, PEDF, PIG35, serpin family F member 1	1.00	infobox
PEDF	Available structures	Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1IMV	1.00	infobox
PEDF	Band	17p13.3	1.00	infobox
PEDF	Band	11\|11 B5	1.00	infobox
PEDF	Bgee	retinal pigment epithelium	1.00	infobox
PEDF	Bgee	pericardium	1.00	infobox
PEDF	Bgee	canal of the cervix	1.00	infobox
PEDF	Bgee	left uterine tube	1.00	infobox
PEDF	Bgee	gallbladder	1.00	infobox
PEDF	Bgee	periodontal fiber	1.00	infobox
PEDF	Bgee	vena cava	1.00	infobox
PEDF	Bgee	right ovary	1.00	infobox
PEDF	Bgee	right lobe of liver	1.00	infobox
PEDF	Bgee	gastric mucosa	1.00	infobox
PEDF	Bgee	calvaria	1.00	infobox
PEDF	Bgee	molar	1.00	infobox
PEDF	Bgee	body of femur	1.00	infobox
PEDF	Bgee	ankle	1.00	infobox
PEDF	Bgee	left lobe of liver	1.00	infobox
PEDF	Bgee	aortic valve	1.00	infobox
PEDF	Bgee	ascending aorta	1.00	infobox
PEDF	Bgee	stroma of bone marrow	1.00	infobox
PEDF	Bgee	lip	1.00	infobox
PEDF	Bgee	cervix	1.00	infobox
PEDF	BioGPS	More reference expression data	1.00	infobox
PEDF	Chr.	Chromosome 17 (human)	1.00	infobox
PEDF	Chr.	Chromosome 11 (mouse)	1.00	infobox
PEDF	Databases	NCBI: entry; OMA: entry	1.00	infobox
PEDF	End	1,777,565 bp	1.00	infobox
PEDF	End	75,313,527 bp	1.00	infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around PEDF bring nearby vocabulary together. In this analysis, examples include Gene, Protein and Cell. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

PEDF
- Gene
- Protein
- Cell
- Human
- Also
- Antiangiogenic
- Expression
- Cancer
- Function
- Apoptosis
- Endothelial
- Eye
pedf
- Gene
- Protein
- Cell
- Human
- Also
- Antiangiogenic
- Expression
- Cancer
- Function
- Apoptosis
- Endothelial
- Eye
protein
- Eye
- Serpin
- Serpinf1
- Neovascularization
- Human
- Location
- Secreted
- Binding
- Bp
- Chr
- Cancer
- Chromosome
gene
- Chromosome
- Human
- Location
- Serpinf1
- Pedf
- Bp
- Chr
- Mrna
- Band
- Pigment
- Region
- Serpin
retinal cell
- Retinal
- Endothelial
- Apoptosis
- Cells
- Secreted
- Expression
- Receptor
- Pedf
- Human
- May
- Serpinf1
- Zinc
cell cycle
- Retinal
- Endothelial
- Apoptosis
- Secreted
- Expression
- Receptor
- Pedf
- Human
- Gene
- Location
- Mrna
- Protein
endothelial cell
- Retinal
- Endothelial
- Function
- Apoptosis
- Secreted
- Expression
- Location
- Mrna
- Receptor
- Pedf
- Epithelium-derived
- Eye
cell proliferation
- Retinal
- Endothelial
- Apoptosis
- Secreted
- Expression
- Receptor
- Pedf
- Human
- Gene
- Location
- Mrna
- Protein

Connections between topic areas Semantic bridges

For PEDF, one of the stronger structural bridges in this analysis connects PEDF with Signaling. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3

PEDF — Signaling · splits 50 ⟂ 19

PEDF — Overview · splits 59 ⟂ 10

PEDF — Gene · splits 60 ⟂ 9

PEDF — Function · splits 60 ⟂ 9

PEDF — Clinical significance · splits 61 ⟂ 8

PEDF — Discovery · splits 62 ⟂ 7

PEDF — Protein · splits 63 ⟂ 6

Map overview Semantic statistics

PEDF

Nodes69

Edges68

Triples158

Avg. degree1.97

Density0.028986

Components1

Source & methodology

TTTA analyzes the structure around PEDF to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Art & Regions, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — PEDF · EN edition · Analysis: TopicsToTalkAbout