Research any topic before you write.

Find related topics. | Discover entities. | See connections. | Build a topical map.

PCNT: Structure, Function & Clinical significance

Pericentrin (kendrin), also known as PCNT and pericentrin-B (PCNTB), is a protein which in humans is encoded by the PCNT gene on chromosome 21. This protein localizes to the centrosome and recruits proteins to the pericentriolar matrix (PCM) to ensure proper centrosome and mitotic spindle formation, and thus, uninterrupted cell cycle progression. This…

Language: English [EN]
Use the mouse wheel or two fingers (on touchscreens) to zoom in and out of the map.
100%
More settings
100% 100% 100% 100% 100%

PCNT topic overview

The analysis highlights Structure, Function and Clinical significance as prominent areas in the source structure around PCNT.

Related topics
71
Source areas
5
Connected nodes
76
Extracted relationships
113
Concept neighborhoods
23
Bridge connections
76

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Function · 19 topics
Structure · 19 topics
Clinical significance · 13 topics
Overview · 12 topics
Interactions · 8 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
PCNT, KEN, MOPD2, PCN, PCNT2, PCNTB, PCTN2, SCKL4, pericentrin
Band
21q22.3 · 10|10 C1
Bgee
gastrocnemius muscle · body of tongue · muscle of thigh · thoracic diaphragm · Skeletal muscle tissue of rectus abdominis
BioGPS
More reference expression data
Chr.
Chromosome 21 (human) · Chromosome 10 (mouse)
Databases
NCBI: entry; OMA: entry

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Structure

Function

Clinical significance

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How PCNT connects Entity context

The extracted context around PCNT shows recurring relationship patterns in the source. For example, PCNT → calmodulin binding, centriolar satellite, centriole, centrosome, ciliary basal body-plasma membrane docking, cilium assembly, cytoplasm, cytoskeleton, cytosol, G2/M transition of mitotic cell cycle, membrane, microtubule, microtubule cytoskeleton organization, microtubule organizing center, mitotic spindle organization, molecular adaptor activity, positive regulation of intracellular protein transport, protein binding, regulation of G2/M transition of mitotic cell cycle, signal transduction Another extracted example is PCNT → ascending aorta, biceps brachii, body of tongue, extraocular muscle, foot, gastrocnemius muscle, glutes, hand, interventricular septum, middle temporal gyrus, muscle of thigh, primary oocyte, secondary oocyte, Skeletal muscle tissue of biceps brachii, Skeletal muscle tissue of rectus abdominis, soleus muscle, thoracic diaphragm, triceps brachii muscle, zygote. Use these groups to spot repeated connection types before inspecting the individual relationships.

PCNT

Top relations

Gene ontology · 20
PCNT → calmodulin binding, centriolar satellite, centriole, centrosome, ciliary basal body-plasma membrane docking, cilium assembly, cytoplasm, cytoskeleton, cytosol, G2/M transition of mitotic cell cycle, membrane, microtubule, microtubule cytoskeleton organization, microtubule organizing center, mitotic spindle organization, molecular adaptor activity, positive regulation of intracellular protein transport, protein binding, regulation of G2/M transition of mitotic cell cycle, signal transduction
Bgee · 19
PCNT → ascending aorta, biceps brachii, body of tongue, extraocular muscle, foot, gastrocnemius muscle, glutes, hand, interventricular septum, middle temporal gyrus, muscle of thigh, primary oocyte, secondary oocyte, Skeletal muscle tissue of biceps brachii, Skeletal muscle tissue of rectus abdominis, soleus muscle, thoracic diaphragm, triceps brachii muscle, zygote
RNA expression pattern · 19
PCNT → ascending aorta, biceps brachii, body of tongue, extraocular muscle, foot, gastrocnemius muscle, glutes, hand, interventricular septum, middle temporal gyrus, muscle of thigh, primary oocyte, secondary oocyte, Skeletal muscle tissue of biceps brachii, Skeletal muscle tissue of rectus abdominis, soleus muscle, thoracic diaphragm, triceps brachii muscle, zygote
related to Structure · 12
PCNT → As, C-terminus, CEP215, CPM, However, In, Li, PACT, PCM, PCNTB, The N-terminus, The PACT
related to Function · 11
PCNT → CEP215, DISC1, Downregulation, G2/M, In, It, Moreover, PCM, PLK1, The, This
related to Clinical significance · 8
PCNT → Additionally, CML, Down, DS, In, MOPDII, Mutations, Seckel
related to Interactions · 3
PCNT → CEP215, CHD3/4, DISC1
Band · 2
PCNT → 10|10 C1, 21q22.3
Chr. · 2
PCNT → Chromosome 10 (mouse), Chromosome 21 (human)
End · 2
PCNT → 46,445,769 bp, 76,278,620 bp

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

protein gene chromosome centrosome bp 21 cell chr human band microtubule pcntb centriole mitotic spindle cycle c-terminus also proteins pcm

PCNT relationships Subject–Predicate–Object triples

TTTA extracted 113 structured relationships around PCNT. Examples in this analysis include PCNT → Aliases → PCNT, KEN, MOPD2, PCN, PCNT2, PCNTB, PCTN2, SCKL4, pericentrin and PCNT → Band → 21q22.3. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
PCNTAliasesPCNT, KEN, MOPD2, PCN, PCNT2, PCNTB, PCTN2, SCKL4, pericentrin1.00infobox
PCNTBand21q22.31.00infobox
PCNTBand10|10 C11.00infobox
PCNTBgeegastrocnemius muscle1.00infobox
PCNTBgeebody of tongue1.00infobox
PCNTBgeemuscle of thigh1.00infobox
PCNTBgeethoracic diaphragm1.00infobox
PCNTBgeeSkeletal muscle tissue of rectus abdominis1.00infobox
PCNTBgeeglutes1.00infobox
PCNTBgeetriceps brachii muscle1.00infobox
PCNTBgeebiceps brachii1.00infobox
PCNTBgeeSkeletal muscle tissue of biceps brachii1.00infobox
PCNTBgeemiddle temporal gyrus1.00infobox
PCNTBgeeprimary oocyte1.00infobox
PCNTBgeezygote1.00infobox
PCNTBgeeinterventricular septum1.00infobox
PCNTBgeesecondary oocyte1.00infobox
PCNTBgeesoleus muscle1.00infobox
PCNTBgeehand1.00infobox
PCNTBgeefoot1.00infobox
PCNTBgeeextraocular muscle1.00infobox
PCNTBgeeascending aorta1.00infobox
PCNTBioGPSMore reference expression data1.00infobox
PCNTChr.Chromosome 21 (human)1.00infobox
PCNTChr.Chromosome 10 (mouse)1.00infobox
PCNTDatabasesNCBI: entry; OMA: entry1.00infobox
PCNTEnd46,445,769 bp1.00infobox
PCNTEnd76,278,620 bp1.00infobox
PCNTEnsemblENSG000001602991.00infobox
PCNTEntrez51161.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around PCNT bring nearby vocabulary together. In this analysis, examples include Pcntb, Gene and Cep215. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • PCNT
    • Pcntb
    • Gene
    • Cep215
    • Contains
    • C-terminus
    • Mopdii
    • Organization
    • Cell
    • Chromosome
    • Centrosome
    • Protein
    • Pericentrin
  • pcnt
    • Pcntb
    • Gene
    • Cep215
    • Contains
    • C-terminus
    • Mopdii
    • Organization
    • Cell
    • Chromosome
    • Centrosome
    • Protein
    • Pericentrin
  • protein
    • Cycle
    • Spindle
    • Cell
    • Thus
    • Cytoplasm
    • Formation
    • Centriole
    • Component
    • Domain
    • Mitotic
    • Pcm
    • Proteins
  • gene
    • Chromosome
    • Location
    • Human
    • Bp
    • Chr
    • Disorders
    • Mouse
    • Pericentrin
    • Protein
    • Cytoplasm
    • Function
    • Seckel
  • centrosome
    • Component
    • Pcm
    • Spindle
    • Cell
    • Formation
    • Protein
    • Cycle
    • Microtubule
    • Thus
    • Cytoplasm
    • Mitotic
    • Organization
  • mitotic spindle
    • Cell
    • Component
    • Cycle
    • Cytoskeleton
    • Thus
    • Function
    • Organization
    • Pcm
    • Spindle
    • Microtubule
    • Protein
    • Mouse
  • cell cycle
    • Cycle
    • Mitotic
    • Cytoskeleton
    • Centrosome
    • Cytoplasm
    • Function
    • Protein
    • Organization
    • Pcm
    • Spindle
    • Gene
    • Encoded
  • c-terminus
    • Contains
    • Centriole
    • Domain
    • May
    • Pcntb
    • Cytoskeleton
    • Mouse
    • Pcnt
    • Cep215
    • Cytoplasm
    • Function
    • Location

Connections between topic areas Semantic bridges

For PCNT, one of the stronger structural bridges in this analysis connects PCNT with Structure. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
PCNTStructure · splits 57 ⟂ 20
PCNTFunction · splits 57 ⟂ 20
PCNTClinical significance · splits 63 ⟂ 14
PCNTOverview · splits 64 ⟂ 13
PCNTInteractions · splits 68 ⟂ 9

Map overview Semantic statistics

PCNT

Nodes77
Edges76
Triples113
Avg. degree1.97
Density0.025974
Components1

Source & methodology

TTTA analyzes the structure around PCNT to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Structure, Function & Clinical significance, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — PCNT · EN edition · Analysis: TopicsToTalkAbout

For writers, content strategists, SEOs, marketers and creators — from quick topic research to advanced semantic analysis.