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Ghrelin: History & Geography

Ghrelin (/ˈɡrɛlɪn/; or lenomorelin, INN) is a hormone primarily produced by enteroendocrine cells of the gastrointestinal tract, especially the stomach, and is also dubbed the "hunger hormone" because it increases the drive to eat. Blood levels of ghrelin are highest before meals when hungry, returning to lower levels after mealtimes. Ghrelin may help…

Language: English [EN]
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Ghrelin topic overview

The analysis highlights History and Geography as prominent areas in the source structure around Ghrelin.

Related topics
63
Source areas
9
Connected nodes
72
Extracted relationships
225
Concept neighborhoods
25
Bridge connections
72

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 23 topics
Function and mechanism of action · 16 topics
Gene, transcription products, and structure · 9 topics
Role(s) in disease · 6 topics
Ghrelin cells · 4 topics
Locations of action · 2 topics
Blood levels · 1 topics
Ghrelin receptor · 1 topics
History and name · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
GHRL, ghrelin, Ghrelin, ghrelin and obestatin prepropeptide, MTLRP
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1P7X,%%s2JSH, 2JSI, 2JSJ
Band
3p25.3 · 6 E3|6 52.84 cM
Bgee
cardia · body of stomach · pancreatic epithelial cell · fundus · bone marrow cell
BioGPS
n/a
Chr.
Chromosome 3 (human) · Chromosome 6 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

History and name

Gene, transcription products, and structure

Ghrelin cells

Function and mechanism of action

Blood levels

Ghrelin receptor

Locations of action

Role(s) in disease

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Ghrelin connects Entity context

The extracted context around Ghrelin shows recurring relationship patterns in the source. For example, Ghrelin → actin polymerization or depolymerization, adult feeding behavior, axon, cartilage development, cortisol secretion, cytoplasm, decidualization, dendrite development, endoplasmic reticulum lumen, energy homeostasis, excitatory postsynaptic potential, extracellular region, extracellular space, G protein-coupled receptor binding, G protein-coupled receptor signaling pathway, gastric acid secretion, gastric emptying, ghrelin receptor binding, glucose metabolic process, glutamatergic synapse Another extracted example is Ghrelin → blood, body of stomach, bone marrow cell, cardia, duodenum, embryo, epithelium of stomach, fundus, islet of Langerhans, migratory enteric neural crest cell, mucous cell of stomach, neural layer of retina, pancreatic ductal cell, pancreatic epithelial cell, pyloric antrum, spermatid, spermatocyte, testicle. Use these groups to spot repeated connection types before inspecting the individual relationships.

Ghrelin

Top relations

Gene ontology · 74
Ghrelin → actin polymerization or depolymerization, adult feeding behavior, axon, cartilage development, cortisol secretion, cytoplasm, decidualization, dendrite development, endoplasmic reticulum lumen, energy homeostasis, excitatory postsynaptic potential, extracellular region, extracellular space, G protein-coupled receptor binding, G protein-coupled receptor signaling pathway, gastric acid secretion, gastric emptying, ghrelin receptor binding, glucose metabolic process, glutamatergic synapse
Bgee · 18
Ghrelin → blood, body of stomach, bone marrow cell, cardia, duodenum, embryo, epithelium of stomach, fundus, islet of Langerhans, migratory enteric neural crest cell, mucous cell of stomach, neural layer of retina, pancreatic ductal cell, pancreatic epithelial cell, pyloric antrum, spermatid, spermatocyte, testicle
RNA expression pattern · 18
Ghrelin → blood, body of stomach, bone marrow cell, cardia, duodenum, embryo, epithelium of stomach, fundus, islet of Langerhans, migratory enteric neural crest cell, mucous cell of stomach, neural layer of retina, pancreatic ductal cell, pancreatic epithelial cell, pyloric antrum, spermatid, spermatocyte, testicle
related to Gene, transcription products, and structure · 11
Ghrelin → C-ghrelin, Five, GHS-R, GOAT, In, It, O-acyltransferase, Obestatin, Side-chains, The, The GHRL
related to Function and mechanism of action · 8
Ghrelin → AgRP, At, ATP, Gastric-brain, Ghrelin-responsiveness, NPY, S6K1, The
related to Immune system · 8
Ghrelin → Additionally, GHSR1a, GOAT, IL-1β, IL-4, INF-γ, TGF-β, TNF-α
related to Alternative names · 7
Ghrelin → A-like, Epsilon, Gr, P/D, The, X-cell, X/A-like
related to Stress/ Hypothalamic-pituitary-adrenal (HPA) axis · 7
Ghrelin → ACTH, CRH, Ghrelin's, GHSR1A, HPA, PVN, Studies
related to Anorexia and obesity · 6
Ghrelin → However, In, Prader, There, Those, Willi
related to Blood levels · 5
Ghrelin → Blood, Both, Circulating, Serum, The

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

levels hormone also cells receptor energy function gastric gene food growth human bp increase chr band blood glucose weight produced

Ghrelin relationships Subject–Predicate–Object triples

TTTA extracted 225 structured relationships around Ghrelin. Examples in this analysis include Ghrelin → Aliases → GHRL, ghrelin, Ghrelin, ghrelin and obestatin prepropeptide, MTLRP and Ghrelin → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1P7X,%%s2JSH, 2JSI, 2JSJ. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
GhrelinAliasesGHRL, ghrelin, Ghrelin, ghrelin and obestatin prepropeptide, MTLRP1.00infobox
GhrelinAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1P7X,%%s2JSH, 2JSI, 2JSJ1.00infobox
GhrelinBand3p25.31.00infobox
GhrelinBand6 E3|6 52.84 cM1.00infobox
GhrelinBgeecardia1.00infobox
GhrelinBgeebody of stomach1.00infobox
GhrelinBgeepancreatic epithelial cell1.00infobox
GhrelinBgeefundus1.00infobox
GhrelinBgeebone marrow cell1.00infobox
GhrelinBgeepancreatic ductal cell1.00infobox
GhrelinBgeeislet of Langerhans1.00infobox
GhrelinBgeeduodenum1.00infobox
GhrelinBgeetesticle1.00infobox
GhrelinBgeeblood1.00infobox
GhrelinBgeeepithelium of stomach1.00infobox
GhrelinBgeepyloric antrum1.00infobox
GhrelinBgeemucous cell of stomach1.00infobox
GhrelinBgeeneural layer of retina1.00infobox
GhrelinBgeespermatid1.00infobox
GhrelinBgeeembryo1.00infobox
GhrelinBgeespermatocyte1.00infobox
GhrelinBgeemigratory enteric neural crest cell1.00infobox
GhrelinBioGPSn/a1.00infobox
GhrelinChr.Chromosome 3 (human)1.00infobox
GhrelinChr.Chromosome 6 (mouse)1.00infobox
GhrelinDatabasesNCBI: entry; OMA: entry1.00infobox
GhrelinEnd10,292,947 bp1.00infobox
GhrelinEnd113,696,841 bp1.00infobox
GhrelinEnsemblENSG000001570171.00infobox
GhrelinEntrez517381.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Ghrelin bring nearby vocabulary together. In this analysis, examples include Levels, Also and Cells. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Ghrelin
    • Levels
    • Also
    • Cells
    • Hormone
    • Food
    • Gastric
    • Increase
    • Energy
    • Function
    • Receptor
    • Produced
    • Found
  • ghrelin
    • Levels
    • Also
    • Cells
    • Hormone
    • Food
    • Gastric
    • Increase
    • Energy
    • Function
    • Receptor
    • Produced
    • Found
  • hormone
    • Growth
    • Secretion
    • Receptor
    • Function
    • Motility
    • Regulation
    • Stomach
    • Effects
    • Glucose
    • Including
    • Neurons
    • Human
  • enteroendocrine cells
    • Stomach
    • Also
    • Role
    • Effects
    • Found
    • Glucose
    • Including
    • Ghrelin
    • Function
    • Receptor
    • Hormone
    • Location
  • gastric acid
    • Bypass
    • Motility
    • Levels
    • Secretion
    • Location
    • Chromosome
    • System
    • Acid
    • Bp
    • Chr
    • Food
    • Gastric
  • appetite
    • Glucose
    • Receptor
    • Location
    • Motility
    • Band
    • Chromosome
    • Regulation
    • Stomach
    • System
    • Blood
    • Bp
    • Chr
  • growth hormone
    • Growth
    • Hormone
    • Secretion
    • Motility
    • Receptor
    • Regulation
    • Glucose
    • Human
    • Function
    • Increase
    • Stomach
    • Effects
  • glucose metabolism
    • Regulation
    • Receptor
    • Effects
    • Location
    • Motility
    • Function
    • Chromosome
    • System
    • Bp
    • Chr
    • Secretion
    • Human

Connections between topic areas Semantic bridges

For Ghrelin, one of the stronger structural bridges in this analysis connects Ghrelin with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
GhrelinOverview · splits 49 ⟂ 24
GhrelinFunction and mechanism of action · splits 56 ⟂ 17
GhrelinGene, transcription products, and structure · splits 63 ⟂ 10
GhrelinRole(s) in disease · splits 66 ⟂ 7
GhrelinGhrelin cells · splits 68 ⟂ 5
GhrelinLocations of action · splits 70 ⟂ 3

Map overview Semantic statistics

Ghrelin

Nodes73
Edges72
Triples225
Avg. degree1.97
Density0.027397
Components1

Source & methodology

TTTA analyzes the structure around Ghrelin to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History & Geography, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Ghrelin · EN edition · Analysis: TopicsToTalkAbout

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