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TYROBP

TYRO protein tyrosine kinase-binding protein is an adapter protein that in humans is encoded by the TYROBP gene.

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Aliases
TYROBP, DAP12, KARAP, PLOSL, TYRO protein tyrosine kinase binding protein, PLOSL1, transmembrane immune signaling adaptor TYROBP
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2L34, 2L35, 4WO1, 4WOL
Band
19q13.12 · 7 B1|7 17.45 cM
Bgee
monocyte · granulocyte · blood · spleen · right lung
BioGPS
More reference expression data
Chr.
Chromosome 19 (human) · Chromosome 7 (mouse)

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Overview

Function

Interactions

Clinical significance

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Map overview Semantic statistics

TYROBP

Nodes20
Edges19
Triples102
Avg. degree1.9
Density0.1
Components1

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TYROBP

Top relations

Gene ontology · 43
TYROBP → actin cytoskeleton organization, apoptotic cell clearance, apoptotic signaling pathway, cell surface, cellular defense response, forebrain development, identical protein binding, immune system process, innate immune response, integral component of membrane, integral component of plasma membrane, integrin-mediated signaling pathway, intracellular signal transduction, macrophage activation involved in immune response, membrane, metal ion binding, microglial cell activation involved in immune response, myeloid leukocyte activation, negative regulation of B cell proliferation, negative regulation of long-term synaptic potentiation
Bgee · 17
TYROBP → blood, bone marrow, bone marrow cell, calvaria, dermis, gallbladder, granulocyte, internal carotid artery, mesenteric lymph nodes, monocyte, periodontal fiber, right lung, right lung lobe, spleen, stroma of bone marrow, tibiofemoral joint, upper lobe of left lung
RNA expression pattern · 17
TYROBP → blood, bone marrow, bone marrow cell, calvaria, dermis, gallbladder, granulocyte, internal carotid artery, mesenteric lymph nodes, monocyte, periodontal fiber, right lung, right lung lobe, spleen, stroma of bone marrow, tibiofemoral joint, upper lobe of left lung
Band · 2
TYROBP → 19q13.12, 7 B1|7 17.45 cM
Chr. · 2
TYROBP → Chromosome 19 (human), Chromosome 7 (mouse)
End · 2
TYROBP → 30,117,010 bp, 35,908,295 bp
Aliases · 1
TYROBP → TYROBP, DAP12, KARAP, PLOSL, TYRO protein tyrosine kinase binding protein, PLOSL1, transmembrane immune signaling adaptor TYROBP
Available structures · 1
TYROBP → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2L34, 2L35, 4WO1, 4WOL
BioGPS · 1
TYROBP → More reference expression data
Databases · 1
TYROBP → NCBI: entry; OMA: entry

Important terminology Word statistics

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Important terminology

gene bp chr human band protein chromosome 19 plosl tyrosine location signaling mouse receptor signal transduction tyro function external polycystic

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
TYROBPAliasesTYROBP, DAP12, KARAP, PLOSL, TYRO protein tyrosine kinase binding protein, PLOSL1, transmembrane immune signaling adaptor TYROBP1.00infobox
TYROBPAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2L34, 2L35, 4WO1, 4WOL1.00infobox
TYROBPBand19q13.121.00infobox
TYROBPBand7 B1|7 17.45 cM1.00infobox
TYROBPBgeemonocyte1.00infobox
TYROBPBgeegranulocyte1.00infobox
TYROBPBgeeblood1.00infobox
TYROBPBgeespleen1.00infobox
TYROBPBgeeright lung1.00infobox
TYROBPBgeebone marrow1.00infobox
TYROBPBgeeperiodontal fiber1.00infobox
TYROBPBgeeupper lobe of left lung1.00infobox
TYROBPBgeebone marrow cell1.00infobox
TYROBPBgeegallbladder1.00infobox
TYROBPBgeetibiofemoral joint1.00infobox
TYROBPBgeemesenteric lymph nodes1.00infobox
TYROBPBgeecalvaria1.00infobox
TYROBPBgeestroma of bone marrow1.00infobox
TYROBPBgeeright lung lobe1.00infobox
TYROBPBgeeinternal carotid artery1.00infobox
TYROBPBgeedermis1.00infobox
TYROBPBioGPSMore reference expression data1.00infobox
TYROBPChr.Chromosome 19 (human)1.00infobox
TYROBPChr.Chromosome 7 (mouse)1.00infobox
TYROBPDatabasesNCBI: entry; OMA: entry1.00infobox
TYROBPEnd35,908,295 bp1.00infobox
TYROBPEnd30,117,010 bp1.00infobox
TYROBPEnsemblENSG000000116001.00infobox
TYROBPEntrez73051.00infobox
TYROBPExternal IDsOMIM: 604142; MGI: 1277211; GeneCards: TYROBP1.00infobox

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