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Noscapine

Noscapine, also known as narcotine, nectodon, nospen, anarcotine and (archaic) opiane, is a benzylisoquinoline alkaloid of the phthalideisoquinoline structural subgroup, which has been isolated from numerous species of the Papaveraceae (poppy) family. It lacks effects associated with opioids such as sedation, euphoria, or analgesia (pain-relief) and…

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3D model (JSmol)
Interactive image
AHFS/Drugs.com
International Drug Names
ATC code
R05DA07 (WHO)
Bioavailability
~30%
CAS Number
128-62-1 Y
ChEBI
CHEBI:73237 N

Topics to explore

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Overview

Medical uses

Side effects

Interactions

Biosynthesis

Mechanism of action

Structure analysis

History

Society and culture

Research

Advanced semantic analysis

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Map overview Semantic statistics

Noscapine

Nodes115
Edges114
Triples144
Avg. degree1.98
Density0.017391
Components1

How this topic connects Entity context

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Noscapine

Top relations

related to Biosynthesis · 53
Noscapine → An N-methylation, Another, AT1, BBE, C1, C2-C3, C4, C8, Canadine, CAS, Chorismic, CNMT, CoA, CXE1, CYP82X1, CYP82X2, CYP82Y1, DOPA, FAD, Finally
has effect · 17
Noscapine → Again, CXCL10, Furthermore, IFN-c, IL-1β, IL-6, In, Khakpour, Moreover, NO, Shiri, The, They, TLR, TNF-α, Various, Zughaier
related to history · 8
Noscapine → Finally, French, He, In, Jean-François Derosne, Narcotine, Paris, Pierre-Jean Robiquet
related to Noscapine in heroin · 8
Noscapine → Belgium, Detection, In, LCMS, Liège, Other, Since, This
related to Structure analysis · 6
Noscapine → C1, C3, HCl, In, The, When
related to Anticancer derivatives · 4
Noscapine → Analogs, N-alkyl, Similarly, Their
related to Noscapine biosynthesis reconstitution · 4
Noscapine → HN1, In, It, Many
related to Recreational use · 4
Noscapine → NMDA, The, There, Unlike
Legal status · 3
Noscapine → AU: S2 (Pharmacy medicine), EU: BE, SE: OTC, In general: ℞ (Prescription only)
related to Mechanism of action · 3
Noscapine → Evidence, Noscapine's, Pretreatment

Important terminology Word statistics

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Important terminology

effects also used anti-inflammatory narcotine antitussive use drugs heroin benzylisoquinoline alcohol inflammation pathway biosynthesis mechanism drug acid alkaloids form catalyzes

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Noscapine3D model (JSmol)Interactive image1.00infobox
NoscapineAHFS/Drugs.comInternational Drug Names1.00infobox
NoscapineATC codeR05DA07 (WHO)1.00infobox
NoscapineBioavailability~30%1.00infobox
NoscapineCAS Number128-62-1 Y1.00infobox
NoscapineChEBICHEBI:73237 N1.00infobox
NoscapineChEMBLChEMBL364713 Y1.00infobox
NoscapineChemSpider242139 Y1.00infobox
NoscapineCompTox Dashboard (EPA)DTXSID40233851.00infobox
NoscapineECHA InfoCard100.004.4551.00infobox
NoscapineElimination half-life1.5–4 h (mean 2.5 h)1.00infobox
NoscapineFormulaC22H23NO71.00infobox
NoscapineKEGGD01036 Y1.00infobox
NoscapineLegal statusAU: S2 (Pharmacy medicine)1.00infobox
NoscapineLegal statusEU: BE, SE: OTC1.00infobox
NoscapineLegal statusIn general: ℞ (Prescription only)1.00infobox
NoscapineMolar mass413.426 g·mol−11.00infobox
NoscapineOther namesNarcotine, nectodon, nospen, anarcotine1.00infobox
NoscapinePregnancy categoryContraindicated1.00infobox
NoscapinePubChem CID2751961.00infobox
NoscapineUNII8V32U4AOQU1.00infobox

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